Non-regular electrical stimulation patterns for treating neurological disorders
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.
1. A method comprising the steps of:
applying electrical current to a targeted neurological tissue region of an animal using a pulse generator according to a non-regular pulse train comprising a plurality of single pulses (singlets) and embedded multiple pulse groups (n-lets), with non-regular, non-random, differing inter-pulse intervals between singlets and n-lets, as well as non-regular interpulse intervals within the n-lets themselves, and
repeating the applying step in succession to treat a neurological symptom.
2. A method according to claim 1
wherein each pulse train comprises an average frequency of less than 100 Hz.
3. A method according to claim 1
wherein the application of the pulse train achieves deep brain stimulation at an average frequency of less than 100 Hz.
4. The method according to claim 1 , wherein the n-let is one or more pulses.
5. A medical stimulation system comprising;
a pulse generator connected to a lead having an electrode;
the pulse generator configured to transmit, through the lead, an electrical signal comprising a repeating succession of non-regular pulse trains, each pulse train comprising a plurality of single pulses (singlets) and embedded multiple pulse groups (n-lets), with non-regular, non-random differing inter-pulse intervals between singlets and n-lets, as well as non-regular inter-pulse intervals within the n-lets themselves, the pulse train repeating in succession to treat a neurological symptom.
6. The pulse generator according to claim 5 wherein each pulse train comprises an average frequency of less than 100 Hz.
7. The pulse generator according to claim 5 , wherein the n-let is one or more pulses.
8. A system for neurological tissue stimulation comprising
a lead sized and configured for implantation in a targeted tissue stimulation region, and
a pulse generator coupled to the lead, the pulse generator operable to apply a temporal pattern of stimulation to the targeted tissue through the lead comprising a pulse train configured as defined in claim 6 .
9. A system according to claim 8
wherein each pulse train comprises an average frequency of less than 100 Hz.