Use of a polyphenol for the treatment of a cancerous or precancerous lesion of the skin
The present invention refers to a method for treating cancerous or precancerous lesions of the skin by administering a pharmaceutically effective amount of a polyphenol to a patient as well as to the production of a medicament thereto.
1. A method for treating a lesion of the skin in a patient, wherein said skin lesion is molluscum contagiosum, said method comprising topically administering a pharmaceutically effective amount of a polyphenol composition comprising (i) a mixture of polyphenols and (ii) a carrier, wherein the composition comprises from about 5% (w/w) to about 20% (w/w) of the mixture of polyphenols, wherein the mixture of polyphenols contains epicatechol, epicatechol gallate, epigallocatechol, epigallocatechol gallate, and qallocatechol gallate.
2. The method according to claim 1 , wherein the patient is a human.
3. The method according to claim 1 , wherein the mixture of polyphenols is isolated from tea or a tea extract.
4. The method according to claim 3 , wherein the tea is a green tea.
5. The method according to claim 3 , wherein the tea extract is a green tea extract.
6. The method according to claim 1 , wherein the mixture of polyphenols contains (−)-epicatechol, (−)-epicatechol gallate, (−)-epigallocatechol, (−)-epigallocatechol gallate, (+) gallocatechol and/or (−)-gallocatechol gallate.
7. The method according to claim 6 , wherein the mixture of polyphenols contains about 2-20% (w/w) epicatechol, about 2-20% (w/w) epicatechol gallate, about 1-25% (w/w) epigallocatechol, about 40-75% (w/w) epigallocatechol gallate, and about 0.5-20% (w/w) gallocatechol gallate.
8. The method according to claim 6 , wherein the mixture of polyphenols contains about 10.8% (w/w) of epicatechol, about 6.5% (w/w) of epicatechol gallate, about 9.2% (w/w) of epigallocatechol, about 54.8% (w/w) of epigallocatechol gallate and/or about 4.0% (w/w) of gallocatechol gallate.
9. The method according to claim 6 , wherein the mixture of polyphenols contains about 10.8% (w/w) of (−)-epicatechol, about 6.5% (w/w) of (−)-epicatechol gallate, about 9.2% (w/w) of (−)-epigallocatechol, about 54.8% (w/w) of (−)-epigallocatechol gallate and about 4.0% (w/w) of (−)-gallocatechol gallate.
10. The method according to claim 1 , wherein the mixture of polyphenols is combined with an additive.
11. The method according to claim 10 , wherein the additive is selected from the group consisting of petroleum jelly, wax, oleyl alcohol, propylene glycol monostearate, propylene glycol monopalmitostearate and/or isopropyl myristate.
12. The method according to claim 1 , wherein the mixture of polyphenols is contained in a carrier selected from the group consisting of an emulsion, a gel, a cream and/or an ointment.
13. The method according to claim 1 , wherein the composition comprises about 15% (w/w) mixture of polyphenols.
14. A method for treating a lesion of the skin in a patient, wherein said skin lesion is molluscum contagiosum, said method comprising topically administering a pharmaceutically effective amount of a polyphenol composition comprising (i) a mixture of polyphenols and (ii) a carrier, wherein the composition comprises about 15% (w/w) mixture of polyphenols, wherein the mixture of polyphenols contains about 10.8% (w/w) of (−)-epicatechol, about 6.5% (w/w) of (−)-epicatechol gallate, about 9.2% (w/w) of (−)-epigallocatechol, about 54.8% (w/w) of (−)-epigallocatechol gallate, and about 4.0% (w/w) of (−)-gallocatechol gallate.