Melanocortin receptor-specific peptides
The invention relates to melanocortin receptor-specific cyclic peptides of Formula (I) or a pharmaceutically acceptable salt thereof, where R 1 , R 2 , R 3 , R 4a , R 4b , R 4c , R 5 , x and y are as defined in the specification. These compounds are particularly useful in the treatments of energy homeostasis and metabolism related (e.g. diabetes), food intake related and/or energy balance and body weight related diseases, disorders and/or conditions, including obesity, overweight and diseases, disorders and/or conditions associated with obesity and/or overweight, such as type 2 diabetes and metabolic syndrome.
1. A cyclic peptide having the structure
or a pharmaceutically acceptable salt thereof.
2. The cyclic peptide according to claim 1 , which is an acetate salt.
3. The cyclic peptide according to claim 1 , which is a trifluoroacetate salt.
4. A cyclic peptide which is Ac-Arg-cyclo(Glu-Pro-D-Phe(4-F)-Arg-Trp-Orn)-NH2 (SEQ ID NO:72).
5. A pharmaceutical composition comprising the cyclic peptide according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
6. A pharmaceutical composition comprising the cyclic peptide according to claim 4 and a pharmaceutically acceptable carrier.