Multi-drug ligand conjugates
Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of a plurality of cytotoxic drugs and vitamin receptor binding ligands. The plurality of drugs may be the same or different. Similarly, the vitamin receptor binding ligands may be the same or different. The conjugates also include a linker that is formed from one or more spacer linkers, heteroatom linkers, and releasable linkers.
1. A compound of the formula
or a pharmaceutically acceptable salt thereof, wherein q is an integer from 0 to 8; or
or a pharmaceutically acceptable salt thereof, wherein AA forms an amino acid; and n is an integer from 0 to 8.
2. The compound of claim 1 wherein q is 1 to 8.
3. The compound of claim 1 wherein n is 1 to 8.
4. A compound of the formula
or
or
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 4 the formula
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 4 the formula
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 4 the formula
or a pharmaceutically acceptable salt thereof.
8. A pharmaceutical composition comprising a drug delivery conjugate of claim 4 , and a pharmaceutically acceptable carrier, diluent, or excipient therefor.
9. A pharmaceutical composition comprising the compound of claim 1 , and a pharmaceutically acceptable carrier, diluent, or excipient therefor.