Methods of organ reconfiguration

1. An endoscopic treatment method, comprising:

introducing an endoscopic device into a lumen of a patient without creating an incision in the patient's skin;

engaging a wall of the lumen with an end effecter of the endoscopic device;

forming a first plication in the wall of the lumen such that a first open pocket is formed in the wall of the lumen, the first open pocket having proximal and distal portions;

forming a second plication in the wall of the lumen such that a second open pocket is formed in the wall of the lumen, the second open pocket having, proximal and distal portions, the proximal portion of the second open pocket being adjacent to the distal portion of the first open pocket, and the first and second open pockets being axially aligned; and

implanting an implant within the open pocket, the implant being configured to stimulate tissue forming the lumen when the implant is implanted within the open pocket to stimulate a sense of satiety in the patient.

2. The method of claim 1 , wherein the axially aligned open pockets form an artificial biological tube.

3. The method of claim 2 , wherein the artificial biological tube is formed in the stomach of the patient.

4. The method of claim 1 , further comprising:

coupling the first plication with the second plication.

5. The method of claim 1 , wherein the first plication is positioned near the gastro-esophageal-junction and configured to function as an artificial gastric valve.

6. The method of claim 1 , wherein the implant is selected from the group consisting of an electrical stimulation device, a mechanical stimulation device, a vibratory device, a sound device, an ultra-sound device, a chemical stimulation device, a neuro-transmitter stimulation device, a thermal stimulation device, a sensory stimulation device, and combinations thereof.

7. The method of claim 1 , further comprising:

coupling the first plication with the second plication to thereby form a first double placation.

8. The method of claim 7 , further comprising forming a second double plication adjacent the first double plication, wherein an open pocket formed by the second double plication and the first and second open pockets formed by the first double plication are axially aligned.

9. The method of claim 8 , further comprising coupling the first double plication with the second double plication.

10. The method of claim 7 , further comprising forming an artificial biological tube by aligning multiple double plications such that open pockets formed by the multiple double plications axially align.

11. The method of claim 10 , wherein the artificial biological tube is formed in the stomach of a patient.

12. The method of claim 1 , wherein the tissue comprises tissue adjacent a gastro-esophageal junction of the patient, and engaging the wall of the lumen comprises engaging the tissue adjacent the gastro-esophageal junction such that the first plication and the implant are positioned adjacent to the gastro-esophageal junction.

13. An endoscopic GERD treatment method, comprising:

introducing an endoscopic device into a lumen of a patient without creating an incision in the patient's skin, the endoscopic device having a shaft with an end effector extending distally from a distal end of the shaft;

engaging a wall of the lumen with the end effecter of the endoscopic device and manipulating the end effector to wrap the wall of the lumen around the shaft of the endoscopic device proximal to the end effector to form a plurality of plications in the wall of the lumen near the patient's gastro-esophageal-junction, the plurality of plications being axially aligned with one another such that an artificial biologic tube is formed that extends axially through the plurality of plications distal to the gastro-esophageal-junction to block gastric fluid from interfering with tissue of the patient's esophagus, the shaft being positioned within the artificial biological tube;

with the wall of the lumen wrapped around the shaft, and with the shaft positioned within the artificial biological tube, securing the plication with at least one anchor; and

with the plication secured with the at least one anchor, removing the shaft from within the artificial biological tube.

14. The method of claim 13 , wherein the artificial biologic tube is between about 0.5 cm and about 5 cm in length.

15. The method of claim 13 , wherein the artificial biologic tube is between about 0.5 cm and about 3 cm in diameter.

16. The method of claim 13 , wherein the plurality of plications extend distally from the gastro-esophageal-junction, wherein the plurality of plications are coupled together.

17. An endoscopic obesity treatment method, comprising:

introducing an endoscopic device into a stomach of a patient without creating an incision in the patient's skin;

engaging a wall of the stomach with an end effecter of the endoscopic device;

forming first and second plications in the wall of the stomach, the first and second plications having proximal and distal portions, the proximal portion of the second open pocket being adjacent to the distal portion of the first open pocket, and the first and second open pockets being axially aligned so as to define an artificial biologic tube within the stomach of the patient that extends, through the first and second plications, thereby reducing a volume of the stomach; and

implanting an implant within the artificial biologic tube, the implant being configured to apply a stimulation to the wall of the lumen when the implant is implanted within the artificial biologic tube to stimulate a sense of satiety in the patient.

18. The method of claim 17 , wherein the artificial biologic tube is between about 0.5 cm and about 10 cm in length.

19. The method of claim 17 , wherein the artificial biologic tube is between about 0.2 cm and about 5 cm in diameter.

20. The method of claim 17 , further comprising forming one or more additional plications in the wall of the stomach, wherein the first placation, second plication, and one or more additional plications are coupled together.