Topical ibuprofen formulations
The present application relates to a topical formulation comprising ibuprofen, a hydroalcoholic based solvent system, a C 1-4 alcohol ester of citric acid, and a surfactant. The formulation shows physical stability over more than one month at ambient temperature and is colorless, essentially odorless, and has a pH value of about 6.5. The formulation of the application shows two to four times improved ibuprofen flux compared to a standard composition.
1. A composition comprising ibuprofen, a hydroalcoholic-based solvent, a C 1-4 alcohol ester of citric acid, and a surfactant, wherein the composition is formulated for topical administration.
2. The composition of claim 1 , comprising about 0.1% (w/w) to about 10% (w/w), about 0.5% (w/w) to about 9.0% (w/w), about 1.0% (w/w) to about 8.0% (w/w), about 2.0% (w/w) to about 7.0% (w/w), about 3.0% (w/w) to about 6.5% (w/w), about 4.0% (w/w) to about 6.0% (w/w), or about 5% (w/w) of ibuprofen.
3. The composition of claim 1 , wherein the C 1-4 alcohol ester of citric acid is a compound of the formula:
wherein R a , R b and R c are the same and are selected from methyl, ethyl, propyl, butyl, isopropyl, isobutyl and t-butyl and R d is selected from the group consisting of H and methyl.
4. The composition of claim 1 , wherein the C IA alcohol ester of citric acid is triethyl citrate.
5. The composition of claim 1 , comprising about 0.5% (w/w) to about 5% (w/w), about 1.5% (w/w) to about 4.5% (w/w), about 2.0% (w/w) to about 4.0% (w/w) or about 3% (w/w), of the C 1-4 alcohol ester of citric acid.
6. The composition of claim 1 , wherein the surfactant is an anionic surfactant or a zwitterionic surfactant, or a mixture thereof, and wherein the anionic surfactant is selected from the group consisting of sodium lauryl sulfate, ammonium lauryl sulfate, sodium dodecyl sulfate, and mixtures thereof.
7. The composition of claim 1 , comprising about 0.5% (w/w) to about 20% (w/w), about 0.75% (w/w) to about 15% (w/w), 1.0% (w/w) to about 10% (w/w), about 1.5% (w/w) to about 9% (w/w), or about 2.0% (w/w) to about 8.0% (w/w) of one or more surfactants.
8. The composition of claim 6 , wherein the zwitterionic surfactant is an N-(cocoalkyl)amidopropyl betaine.
9. The composition of claim 1 , comprising about 10% (w/w) to about 60% (w/w), about 15% (w/w) to about 55% (w/w), or about 20% (w/w) to about 50% (w/w) of water, and about 10% (w/w) to about 60% (w/w), about 15% (w/w) to about 55% (w/w), or about 20% (w/w) to about 50% (w/w) of alcohol.
10. The composition of claim 9 , wherein the alcohol is selected from the group consisting of ethanol, isopropanol, 2-(2-ethoxyethoxy)ethanol(transcutol), and mixtures thereof.
11. The composition of claim 10 , additionally comprising a diol.
12. The composition of claim 11 , wherein the diol is selected from the group consisting of propylene glycol, butanediol, butynediol, pentanediol, hexanediol, octanediol, neopentyl glycol, 2-methyl-1,3-propanediol, diethylene glycol, triethylene glycol, tetraethylene glycol, dipropylene glycol, dibutylene glycol, and mixtures thereof.
13. The composition of claim 12 , wherein the diol is propylene glycol.
14. The composition of claim 12 , comprising about 0% (w/w) to about 20% (w/w), about 1.0% (w/w) to about 15% (w/w), or about 4% (w/w) to about 15% (w/w) of propylene glycol.
15. The composition of claim 1 , comprising at least one thickening agent selected from the group consisting of hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose, hydroxyethyl cellulose, hydroxyethyl methyl cellulose, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, dextran, guar gum, pectin, starch, cellulose, and mixtures thereof.
16. The composition of claim 1 , comprising ibuprofen, ethanol, water, triethyl citrate, lactic acid, transcutol, propylene glycol and N-(cocoalkyl)amidopropyl betaine.
17. The composition of claim 16 , comprising:
about 1% (w/w) to about 10% (w/w) ibuprofen;
about 25% (w/w) to about 35% (w/w) ethanol;
about 15% (w/w) to about 25% (w/w) transcutol;
about 1% (w/w) to about 10% (w/w) propylene glycol;
about 25% (w/w) to about 35% (w/w) water;
about 2% (w/w) to about 5% (w/w) triethyl citrate;
about 0.5% (w/w) to about 2.5% (w/w) lactic acid; and
about 2% (w/w) to about 10% (w/w) N-(cocoalkyl)amidopropyl betaine.
18. The composition of claim 16 , wherein the water component is buffered.
19. The composition of claim 18 , additionally comprising a cellulosic thickening agent in an amount of about 0.5% (w/w) to about 2.0% (w/w).
20. A method for treating pain comprising applying an effective amount of a composition comprising ibuprofen, a hydroalcoholic-based solvent, a C 1-4 alcohol ester of citric acid and a surfactant, wherein the composition is formulated for topical administration, to a subject in need thereof.