Antibody against the CSF-1R
The present invention provides antibodies specific for the CSF-1R, compositions comprising said antibodies and methods of treatment using such compositions.
1. An isolated, recombinant, or purified antibody that specifically binds to human CSF-1R, comprising a heavy chain and a light chain, wherein the heavy chain comprises SEQ ID NO:37 or SEQ ID NO:38, and the light chain comprises SEQ ID NO:39, SEQ ID NO:40, or SEQ ID NO:41.
2. An isolated, recombinant, or purified antibody that specifically binds to human CSF-1R, comprising:
(a) a heavy chain comprising a first variable region, and
(b) a light chain comprising a second variable region;
wherein the first variable region comprises SEQ ID NO:42 or SEQ ID NO:43, and the second variable region comprises SEQ ID NO:44, SEQ ID NO:45, or SEQ ID NO:46.
3. The antibody of claim 1 , wherein the heavy chain comprises SEQ ID NO:37, and the light chain comprises SEQ ID NO:39.
4. The antibody of claim 1 , wherein the heavy chain comprises SEQ ID NO:38, and the light chain comprises SEQ ID NO:40.
5. The antibody of claim 1 , wherein the heavy chain comprises SEQ ID NO:37, and the light chain comprises SEQ ID NO:41.
6. The antibody of claim 2 , wherein the first variable region comprises SEQ ID NO:42, and the second variable region comprises SEQ ID NO:44.
7. The antibody of claim 2 , wherein the first variable region comprises SEQ ID NO:43, and the second variable region comprises SEQ ID NO:45.
8. The antibody of claim 2 , wherein the first variable region comprises SEQ ID NO:42, and the second variable region comprises SEQ ID NO:46.