Granted Patent
B2
US 8,470,991 · App. 12/768,678 · Granted Jun 25, 2013
Immunocytokine sequences and uses thereof
Inventors:
Stephen D. Gillies (Carlisle, MA); Kin-Ming Lo (Lexington, MA); Susan Xiuqi Qian (Concord, MA)
Assignee:
Merck Patent GmbH
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Abstract
The invention provides a family of antibodies that specifically bind the human cell surface glycosphingolipid GD2. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies may be coupled to a therapeutic agent and used in the treatment of cancer.
Claims (1)
1. An isolated nucleic acid encoding an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1.
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 2, 2013
From: GILLIES, STEPHEN D.; LO, KIN-MING; QIAN, SUSAN X.
To: EMD LEXIGEN RESEARCH CENTER CORP.
Reel/Frame 030338/0685 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 2, 2013
From: EMD SERONO RESEARCH CENTER, INC.
To: MERCK PATENT GMBH
Reel/Frame 030338/0892 →
CHANGE OF NAME
Recorded May 2, 2013
From: EMD LEXIGEN RESEARCH CENTER CORP.
To: EMD SERONO RESEARCH CENTER, INC.
Reel/Frame 030341/0825 →
Continuity (4)
Provisional Application
60433945
· Dec 17, 2002