System and a method for pharmaceutical dosage preparation using jettable microemulsions
View Patent ↗A jettable solution includes an oil, the oil being one of a naturally occurring oil, an edible oil, or a removable oil, an edible surfactant, an edible aqueous solution, and a pharmaceutical solubilized into the naturally occurring oil, in which the naturally occurring oil, the pharmaceutical, the surfactant, and the aqueous solution form a microemulsion.
1. A method for dispensing an oral medication comprising:
selectively dispensing a microemulsion comprising a water insoluble pharmaceutical in a gradient amount with an inkjet material dispenser onto an edible substrate;
in which the dispensed pharmaceutical is initially released into a patient at a relatively higher concentration and decreasingly released into a patient at a relatively lower concentration thereafter.
2. The method of claim 1 , further comprising preparing the microemulsion by forming a combination of an oil, an edible surfactant, and an aqueous solution;
in which the oil comprises one of a naturally occurring pharmaceutical solubilizing oil or a removable oil; and
the combination resulting in a formation of a plurality of micelles emulsified in a solution.
3. The method of claim 2 , in which preparing the microemulsion further comprises one of agitating the combination or adding thermal energy to the combination.
4. The method of claim 2 , in which the oil comprises one of a castor oil, an oleic acid and an oleyl alcohol, a coconut oil, a mineral oil, a cottonseed oil, a squalene, a safflower oil, or a fatty ester.
5. The method of claim 1 , in which the pharmaceutical comprises one of a water insoluble peptide, an antimicrobial, a proton pump inhibitor, a calcium channel blocker, a beta blocker, an anesthetic, a steroid, an antioxidant, a rennin inhibitor, an alkaloid, a cytostatica, an anti-coagulant, a lipid regulating agent, an anti-depressant, a neuroleptic, an immunosuppressant, an immunomodulator, an antibiotic, an anti-inflammatory agent, an antineoplastic, a paclitaxel, a taxol, a tyloxapol, a docetaxel, a lovastatin, an indometacine, a diclofenac, a naproxen, a dexibuprofen, a rofecoxib, a celecoxib, a celecoxib nitrendipine, a flurbiprofen, a diclofenac, a ketoprofen, a piroxicam, a tenoxicam, a vincristine, a vinblastine, an insulin, a calcitonin, an erythropoietin, a cephalosporin, a desmopressin, an etoposide, a leuprolide, or a cyclosporin.
6. The method of claim 2 , in which the edible surfactant comprises one of a lecithin, a sphingolipid, a galacto lipid, an ethoxylated castor oil, a polyoxyl 40 hydrogenated castor oil, an ethoxylated fatty ester, a sucrose fatty ester, a sorbitol, a sorbitan, a polyoxyethylene derivative, an alkyl glucoside, an alkyl polyglucoside, an ethoxylated mono-hydroxy stearic acid, a bile salt, a polyoxyethylene-sorbitan monooleate, a polyoxyethylene-sorbitan monopalmitate, a polyoxyethylene-sorbitan monolaurate, a polyoxyethylene sorbitan monostearate, cholic acid, nicotinic acid and nicotinamide derivatives, acetylininc alcohols, polyhydroxylated alcohols, or aromatic sulfonate salts.
7. The method of claim 2 , in which the edible surfactant comprises an ion-pair formation between an amino acid and a fatty acid.
8. The method of claim 7 , in which:
the amino acid comprises one of an L-arginine or an L-lysine; and
the fatty acid comprises one of a stearic acid or an oleic acid.
9. The method of claim 5 , in which the cyclosporin comprises one of cyclosporin A, dihydrocyclosporin C, dihydrocyclosporin D, cyclosporin D.
10. The method of claim 6 , in which the aromatic sulfonate salts comprise one of a xylene sulfonate, naphthalene sulfonate, cymene sulfonate, or Ethylene Oxide-Propylene Oxide block (pluronic) polymers.