Prodrugs of 2,4-pyrimidinediamine compounds and their uses
The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds, compositions comprising the prodrugs, intermediates and methods for synthesizing the prodrugs and methods of using the prodrugs in a variety of applications.
1. A method for treating rheumatoid arthritis in a subject, comprising administering to the subject an effective amount of a compound according to the formula
in the form of a pharmaceutically acceptable organic base salt.
2. The method of claim 1 , wherein the compound or the pharmaceutically acceptable salt thereof is in the form of a hydrate.
3. The method of claim 1 wherein the base salt is ethanolamine.
4. The method of claim 1 wherein the base salt is diethanolamine.
5. The method of claim 1 wherein the base salt is triethanolamine.
6. The method of claim 1 wherein the base salt is N-methylglucamine.
7. The method of claim 1 wherein the base salt is morpholine.
8. The method of claim 1 wherein the base salt is piperidine.
9. The method of claim 1 wherein the base salt is dimethylamine.
10. The method of claim 1 wherein the base salt is diethylamine.