IP Library › Granted Patent US 8,476,434

Granted Patent B2

US 8,476,434 · App. 12/952,156 · Granted Jul 2, 2013

Protein kinase modulators and method of use

Inventors: Stephanie D. Geuns-Meyer (Medford, MA); Brian L. Hodous (Cambridge, MA); Stuart C. Chaffee (Boston, MA); Paul Tempest (Boston, MA); Ning Xi (Thousand Oaks, CA); Phillip R. Olivieri (Charlestown, MA); Joseph L. Kim (Wayland, MA); Steven Bellon (Wellesley, MA); Xiaotian Zhu (Newton, MA); Yuan Cheng (Newbury Park, CA); Brian K. Albrecht (Cambridge, MA); Vinod F. Patel (Acton, MA); Victor J. Cee (Thousand Oaks, CA); Karina Romero (Cambridge, MA); Hanh Nho Nguyen (Arlington, MA); Holly L. Deak (Brookline, MA); Rebecca E. Johnson (Arlington, VA)

Assignee: Amgen Inc.

View Patent ↗

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US 8,476,434
App. No.: 12/952,156
Granted: Jul 2, 2013
Kind: B2

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H 1-5 and R 1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.

Claims (948)

1. A compound of Formula II:

or a stereoisomer, solvate, hydrate or pharmaceutically acceptable salt thereof, wherein

A is N or CR 10 ;

B is N or CR 11 ;

D is N or CR 12 ;

G is NR 13 , O, S;

R 1 is H, halo, haloalkyl, NO 2 , CN, NR 13 R 13 , OR 13 , SR 13 , (CHR 13 ) n R 13 ; alternatively R 1 taken together with R 10 forms a partially or fully unsaturated 5- or 6-membered ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N and S, and the ring optionally substituted independently with 1-3 substituents of R 13 , halo, haloalkyl, oxo, NO 2 , CN, SR 13 , OR 13 , OC(O)R 13 , COOR 13 , C(O)R 13 , C(O)NR 13 R 13 , NR 13 R 13 or NR 13 R 14 ;

R 2 is H, halo, haloalkyl, CN, SR 13 , OR 13 , C(O)R 13 , C 1-10 alkynyl, C 1-10 alkynyl, or C 3-8 cycloalkyl wherein the C 1-10 alkyl, C 1-10 alkyenyl, C 1-10 alkynyl and C 3-8 cycloalkyl is optionally substituted with one or more substituents of R 13 ;

each of R 3 and R 4 , independently, is H, halo, haloalkyl, CN, SR 13 , OR 13 , NR 13 R 13 , NR 13 R 14 , C(O)R 13 ,

each of R 5 and R 6 , independently, is H, halo, haloalkyl, CN, SR 13 , OR 13 , NR 13 R 13 , NR 13 R 14 , C(O)R 13 , COOR 13 , C 1-10 alkyl, C 1-10 alkenyl, C 1-10 alkynyl or C 3-8 cycloalkyl, wherein the C 1-10 alkyl, C 1-10 alkyenyl, C 1-10 alkynyl and C 3-8 cycloalkyl is optionally substituted with one or more substituents of R 13 ;

one of R 7 and R 8 is SR 13 , OR 13 , NR 13 R 13 , NR 13 R 14 , C(O)NR 13 R 13 , C(O)NR 13 R 14 , NR 13 C(O)R 13 , NR 13 (COOR 13 ), NR 13 C(O)NR 13 R 13 , S(O) 2 NR 13 R 13 , S(O) 2 NR 13 R 14 , NR 13 S(O) 2 NR 13 R 13 , NR 13 S(O) 2 R 13 , NR 13 S(O) 2 R 13 S(O) 2 R 14 , C 1-3 alkyl optionally substituted with one or more substituents of R 15 or R 16 ; and

the other of R 7 and R 8 is H, halo, haloalkyl, haloalkoxyl, CN, OH, NO 2 , NH 2 , SH, acetyl, C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl or C 1-10 -thioalkoxyl;

each of R 9 , R 10 , and R 11 , independently, is H, halo, haloalkyl, NO 2 , CN, C 1-4 alkyl, C 1-4 alkoxyl, C 1-4 alkenyl, C 1-4 alkynyl or C 3-6 cycloalkyl;

each R 13 , independently, is H, C 1-10 alkyl, C 1-10 alkenyl, C 1-10 alkynyl, C 3-8 cycloalkyl, C 4-8 cycloalkenyl, R 15 or R 16 , each of which is optionally substituted with one or more substituents of R 15 , R 16 or R 18 ;

R 14 is C(O)R 18 , COOR 18 , S(O) 2 R 18 or R 16 ;

R 15 is halo, haloalkyl, NO 2 , CN, SR 18 , OR 18 , OC(O)R 18 , NR 16 R 18 , NR 18 R 18 , COOR 16 , C(O)R 16 , COOR 18 , C(O)R 18 , C(O)NR 16 R 18 , C(O)NR 18 R 18 , S(O) 2 NR 16 R 18 , S(O) 2 NR 18 R 18 , S(O) 2 R 16 , S(O) 2 R 18 , C(O)C(O)R 18 , NR 18 C(O)NR 16 R 18 , NR 18 C(O)NR 18 R 18 , NR 18 C(O)C(O)R 18 , NR 18 C(O)R 16 , NR 18 C(O)R 18 , NR 18 (COOR 16 ), NR 18 (COOR 18 ), NR 18 S(O) 2 NR 16 R 18 , NR 18 S(O) 2 NR 18 R 18 , NR 18 S(O) 2 R 18 , NR 18 S(O) 2 R 16 , NR 18 C(O)C(O)NR 16 R 18 or NR 18 C(O)C(O)NR 18 R 18 ;

R 16 is a saturated or unsaturated 5-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, the ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, the heteroatoms selected from O, N, or S, wherein 0, 1, 2 or 3 atoms of each ring is optionally substituted independently with 1-3 substituents of R 17 , R 20 , C 1-10 alkyl, C 1-10 alkenyl, C 1-10 alkynyl, C 3-8 cycloalkyl or C 4-8 cycloalkenyl, each of which is optionally substituted with one or more substituents of R 17 , R 18 or R 20 ;

R 17 is halo, haloalkyl, oxo, NO 2 , CN, SR 18 , OR 18 , OC(O)R 18 , NR 18 R 18 , NR 18 R 20 , COOR 18 , C(O)R 18 , COOR 20 , C(O)R 20 , C(O)NR 18 R 18 , C(O)NR 18 R 20 , S(O) 2 NR 18 R 18 , S(O) 2 NR 18 R 20 , S(O) 2 R 18 , S(O) 2 R 20 , C(O)C(O)R 18 , NR 18 C(O)NR 18 R 18 , NR 18 C(O)NR 18 R 20 , NR 18 C(O)C(O)R 18 , NR 18 C(O)R 18 , NR 18 C(O)R 20 , NR 18 (COOR 18 ), NR 18 (COOR 20 ), NR 18 S(O) 2 NR 18 R 18 , NR 18 S(O) 2 NR 18 R 20 , NR 18 S(O) 2 R 18 , NR 18 S(O) 2 R 20 , NR 18 C(O)C(O)NR 18 R 18 or NR 18 C(O)C(O)NR 18 R 20 ;

each R 18 , independently, is H, C 1-10 alkyl, C 1-10 alkenyl, C 1-10 alkynyl, C 3-8 cycloalkyl, C 4-8 cycloalkenyl, R 19 or R 20 , each of which is optionally substituted with 1-3 substituents of R 21 ;

R 19 , independently, is C(O)R 20 , C(O)R 21 , COOR 20 , COOR 21 , S(O) 2 R 20 or S(O) 2 R 21 ;

R 20 is a saturated or unsaturated 5-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, the ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, the heteroatoms selected from O, N, or S, wherein 0, 1, 2 or 3 atoms of each ring is optionally substituted independently with 1-3 substituents of C 1-10 alkyl, C 1-10 alkenyl, C 1-10 alkynyl, C 3-8 cycloalkyl or C 4-8 cycloalkenyl, each of which is optionally substituted with one or more substituents of R 21 ;

each R 21 , independently, is H, halo, haloalkyl, haloalkoxyl, oxo, CN, OH, SH, NO 2 , NH 2 , acetyl, C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl or a saturated or partially or fully unsaturated 5-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, wherein each of the C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl and ring of said ring system is optionally substituted independently with 1-3 substituents of halo, haloalkyl, CN, NO 2 , NH 2 , OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, cyclopropyl, butyl, isobutyl, tert-butyl, methylamino, dimethylamino, ethylamino, diethylamino, propylamino, isopropylamino, dipropylamino, diisopropylamino, benzyl or phenyl; and

n is 0, 1, 2, 3, 4 or 5,

provided that (1) when A is N, then B is not N, and when B is N, then A is not N; and (2) when either of R 1 or R 2 is substituted or unsubstituted NH-phenyl, then no more than four of R 5 , R 6 , R 7 , R 8 and R 9 is H.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein

A is N;

B is CH;

D is CH;

G is NH, O or S;

R 1 is H, NR 13 R 13 , OR 13 , SR 13 or CH 2 R 13 ;

R 2 is H, halo, NO 2 , CN, C 1-10 alkyl or C 1-10 alkoxyl;

each of R 3 and R 4 , independently, is H, halo, haloalkyl, CN, methyl, ethyl, propyl, methoxyl, ethoxyl, thiomethyl, thioethyl, OH, NH 2 , —N—CH 3 or acetyl;

each of R 5 and R 6 , independently, is H, halo, CN, methyl, ethyl, propyl, methoxyl, ethoxyl, thiomethyl, thioethyl, OH, NH 2 , —N—CH 3 or acetyl;

one of R 7 and R 8 is SR 13 , OR 13 , NR 13 R 13 , NR 13 R 14 , C(O)R 13 , C(O)NR 13 R 13 , C(O)NR 13 R 14 , NR 13 C(O)R 13 , or C 1-3 alkyl optionally substituted with one or more substituents of R 15 or R 16 ;

the other of R 7 and R 8 is H, halo, haloalkyl, haloalkoxyl, CN, OH, NH 2 , acetyl, methyl, ethyl, propyl, methoxyl, ethoxyl, thiomethyl, thioethyl, —N—CH 3 or acetyl;

R 9 is H;

R 14 is C(O)R 18 , COOR 18 , S(O) 2 R 18 or R 16 ;

R 15 is halo, haloalkyl, oxo, NO 2 , CN, SR 18 , OR 18 , OC(O)R 18 , NR 16 R 18 , NR 18 R 18 , COOR 16 , C(O)R 16 , COOR 18 , C(O)R 18 , C(O)NR 16 R 18 , C(O)NR 18 R 18 , S(O) 2 NR 16 R 18 , S(O) 2 NR 18 R 18 , S(O) 2 R 16 , S(O) 2 R 18 , C(O)C(O)R 18 , NR 18 C(O)NR 16 R 18 , NR 18 C(O)NR 18 R 18 , NR 18 C(O)C(O)R 18 , NR 18 C(O)R 16 , NR 18 C(O)R 18 , NR 18 (COOR 16 ), NR 18 (COOR 18 ), NR 18 S(O) 2 NR 16 R 18 , NR 18 S(O) 2 NR 18 R 18 , NR 18 S(O) 2 R 18 , NR 18 S(O) 2 R 16 , NR 18 C(O)C(O)NR 16 R 18 or NR 18 C(O)C(O)NR 18 R 18 ;

R 17 is halo, haloalkyl, NO 2 , CN, SR 18 , OR 18 , OC(O)R 18 , NR 18 R 18 , NR 18 R 20 , COOR 18 , C(O)R 18 , COOR 20 , C(O)R 20 , C(O)NR 18 R 18 , C(O)NR 18 R 20 , S(O) 2 NR 18 R 18 , S(O) 2 NR 18 R 20 , S(O) 2 R 18 , S(O) 2 R 20 , C(O)C(O)R 18 , NR 18 C(O)NR 18 R 18 , NR 18 C(O)NR 18 R 20 , NR 18 C(O)C(O)R 18 , NR 18 C(O)R 18 , NR 18 C(O)R 20 , NR 18 (COOR 18 ), NR 18 (COOR 20 ), NR 18 S(O) 2 NR 18 R 18 , NR 18 S(O) 2 NR 18 R 20 , NR 18 S(O) 2 R 18 , NR 18 S(O) 2 R 20 , NR 18 C(O)C(O)NR 18 R 18 or NR 18 C(O)C(O)NR 18 R 20 ;

R 19 , independently, is C(O)R 20 , C(O)R 21 , COOR 20 , COOR 21 , S(O) 2 R 20 or S(O) 2 R 21 ;

3. The compound of claim 1 , or a pharmaceutically acceptable thereof, wherein,

A is CH;

B is N;

D is CH;

G is NH, O or S;

R 1 is H, NR 13 R 13 , OR 13 , SR 13 or CH 2 R 13 ; alternatively R 1 taken together with R 10 forms a partially or fully unsaturated 5- or 6-membered ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N and S, and the ring optionally substituted independently with 1-3 substituents of R 13 , halo, haloalkyl, oxo, NO 2 , CN, SR 13 , OR 13 , OC(O)R 13 , COOR 13 , C(O)R 13 , C(O)NR 13 R 13 , NR 13 R 13 or NR 13 R 14 ;

R 2 is H, halo, NO 2 , CN, C 1-10 alkyl or C 1-10 alkoxyl;

each of R 3 and R 4 , independently, is H, halo, haloalkyl, CN, methyl, ethyl, propyl, methoxyl, ethoxyl, thiomethyl, thioethyl, OH, NH 2 , —N—CH 3 or acetyl;

each of R 5 and R 6 , independently, is H, halo, haloalkyl, CN, methyl, ethyl, propyl, methoxyl, ethoxyl, thiomethyl, thioethyl, OH, NH 2 , —N—CH 3 or acetyl;

the other of R 7 and R 8 is H, halo, haloalkyl, haloalkoxyl, CN, OH, NH 2 , acetyl methyl, ethyl, propyl, methoxyl, ethoxyl, thiomethyl, thioethyl, —N—CH 3 or acetyl;

R 9 is H;

R 14 is C(O)R 18 , COOR 18 , S(O) 2 R 18 or R 16 ;

R 19 , independently, is C(O)R 20 , C(O)R 21 , COOR 20 , COOR 21 , S(O) 2 R 20 or S(O) 2 R 21 ;

4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein,

A is N;

B is CH;

D is H;

G is NH, O or S;

R 1 is H, NR 13 R 13 , OR 13 , SR 13 or CH 2 R 13 ;

R 2 is H;

each of R 3 and R 4 , independently, is H, halo, haloalkyl, CN, methyl, ethyl, propyl, methoxyl, ethoxyl, thiomethyl, thioethyl, OH, NH 2 , —N—CH 3 or acetyl;

each of R 5 and R 6 , independently, is H, halo, haloalkyl, CN, methyl, ethyl, propyl, methoxyl, ethoxyl, thiomethyl, thioethyl, OH, NH 2 , —N—CH 3 or acetyl;

R 7 is NR 13 R 13 , C(O)R 13 , C(O)NR 13 R 13 , NR 13 C(O)R 13 , S(O) 2 R 13 , S(O) 2 NR 13 R 13 , NR 13 S(O) 2 R 13 or C 1-3 alkyl optionally substituted with NR 18 R 18 , C(O)R 18 , C(O)NR 18 R 18 , NR 13 C(O)R 18 , S(O) 2 R 18 , S(O) 2 NR 18 R 18 , NR 18 S(O) 2 NR 18 R 18 , or NR 18 S(O) 2 R 18 ;

R 8 is H, halo, haloalkyl, haloalkoxyl, CN, OH, NH 2 , acetyl, methyl, ethyl, propyl, methoxyl, ethoxyl, thiomethyl, thioethyl, —N—CH 3 or acetyl;

R 9 is H;

each R 13 , independently, is H, C 1-10 alkyl, C 1-10 alkenyl, C 1-10 alkynyl, phenyl, pyridyl, pyrimidinyl, triazinyl, quinolinyl, dihydroquinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, quinazolinyl, isoquinazolinyl, thiophenyl, furyl, tetrahydrofuranyl, pyrrolyl, pyrazolyl, thieno-pyrazolyl, imidazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, benzothiazolyl, oxazolyl, oxadiazolyl, benzoxazolyl, benzoxadiazolyl, isoxazolyl, isothiazolyl, indolyl, azaindolyl, 2,3-dihydroindolyl, isoindolyl, indazolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, imidazo-pyridinyl, purinyl, benzotriazolyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrrolidinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, 2,3-dihydro-1,4-benzoxazinyl, 1,3-benzodioxolyl, cyclopropyl, cyclobutyl, azetidinyl, cyclopentyl, cyclohexyl, cycloheptyl, pyranyl, naphthyl or benzyl, each of which is optionally independently substituted with 1-5 substituents of R 15 , R 16 or R 18 ;

R 16 is phenyl, pyridyl, pyrimidinyl, triazinyl, quinolinyl, dihydroquinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, quinazolinyl, isoquinazolinyl, thiophenyl, furyl, tetrahydrofuranyl, pyrrolyl, pyrazolyl, thieno-pyrazolyl, imidazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, benzothiazolyl, oxazolyl, oxadiazolyl, benzoxazolyl, benzoxadiazolyl, isoxazolyl, isothiazolyl, indolyl, azaindolyl, 2,3-dihydroindolyl, isoindolyl, indazolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, imidazo-pyridinyl, purinyl, benzotriazolyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrrolidinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, 2,3-dihydro-1,4-benzoxazinyl, 1,3-benzodioxolyl, cyclopropyl, cyclobutyl, azetidinyl, cyclopentyl, cyclohexyl, cycloheptyl, pyranyl or naphthyl, each of which is optionally substituted independently with 1-3 substituents of R 17 , R 18 or R 20 ;

each R 18 , independently, is H, methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, t-butyl, pentyl, hexyl, acetyl or C 1-10 -alkoxyl, each of which is optionally independently substituted with 1-3 substituents of R 21 ;

R 20 is phenyl, pyridyl, pyrimidinyl, triazinyl, quinolinyl, dihydroquinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, quinazolinyl, isoquinazolinyl, thiophenyl, furyl, tetrahydrofuranyl, pyrrolyl, pyrazolyl, thieno-pyrazolyl, imidazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, benzothiazolyl, oxazolyl, oxadiazolyl, benzoxazolyl, benzoxadiazolyl, isoxazolyl, isothiazolyl, indolyl, azaindolyl, 2,3-dihydroindolyl, isoindolyl, indazolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, imidazo-pyridinyl, purinyl, benzotriazolyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrrolidinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, 2,3-dihydro-1,4-benzoxazinyl, 1,3-benzodioxolyl, cyclopropyl, cyclobutyl, azetidinyl, cyclopentyl, cyclohexyl, cycloheptyl, pyranyl or naphthyl, each of which is optionally substituted independently with 1-3 substituents of R 21 ;

each R 21 , independently, is H, Cl, Br, F, I, CF 3 , CF 2 CF 3 , NO 2 , CN; acetyl, oxo, haloalkyl, haloalkoxyl, CN, OH, SH, NO 2 , NH 2 , acetyl, C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl or a saturated or partially or fully unsaturated 5-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, wherein each of the C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl and ring of said ring system is optionally substituted independently with 1-3 substituents of halo, haloalkyl, CN, NO 2 , NH 2 , OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, cyclopropyl, butyl, isobutyl, tert-butyl, methylamino, dimethylamino, ethylamino, diethylamino, propylamino, isopropylamino, dipropylamino, diisopropylamino, benzyl or phenyl; and

n is 0, 1, 2 or 3.

5. A compound or a pharmaceutically acceptable salt thereof, selected from:

4-methyl-N-(3-(1-methylethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-(1,1-dimethylethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-(3-(dimethylamino)propyl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(5-(1,1-dimethylethyl)-3-isoxazolyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(4-(trifluoromethyl)phenyl)benzamide;

4-chloro-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(4-(trifluoromethyl)phenyl)benzamide;

N-(4-(1,1-dimethylethyl)-3-(3-(4-morpholinyl)propyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide;

4-chloro-N-(3-(1-methylethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-fluoro-N-(3-(1-methylethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-fluoro-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide;

4-fluoro-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(3-((3R)-tetrahydro-3-furanyloxy)-5-(trifluoromethyl)phenyl)benzamide;

N-(1-acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-4-fluoro-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-((1R)-1-cyclohexylethyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-((1S)-1-cyclohexylethyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4,4-dimethyl-1,2,3,4-tetrahydro-7-quinolinyl)-4-fluoro-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-(1,1-dimethylethyl)-1-methyl-1H-pyrazol-5-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-(methyloxy)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide;

N-(3-amino-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(2-fluoro-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-chlorophenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(4-(phenyloxy)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(2-methyl-5-((6-(trifluoromethyl)-1H-indol-1-yl)carbonyl)phenyl)-3-(4-pyrimidinyl)-2-pyridinamine;

N-(4-(dimethylamino)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(3-(methyloxy)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(2-fluoro-3-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(2,3-dihydro-1H-inden-5-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(4-((phenylmethyl)oxy)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-((3-(trifluoromethyl)phenyl)methyl)benzamide;

N-(3-(dimethylamino)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-fluoro-3-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(2-chloro-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(3-methylphenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-((2-(trifluoromethyl)phenyl)methyl)benzamide;

N-(1H-indazol-5-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-chloro-3-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(2-methyl-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3,4-dimethylphenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(3-((phenylmethyl)oxy)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-((4-(trifluoromethyl)phenyl)methyl)benzamide;

N-(1H-indazol-6-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(4-(methyloxy)-3-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(2-(methyloxy)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-(aminocarbonyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-chloro-4-((trifluoromethyl)oxy)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-cyclohexylphenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-(dimethylamino)-2,2-dimethylpropyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-(hydroxymethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(5-chloro-2-fluorophenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-chloro-4-fluorophenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-hydroxy-2,2-dimethylpropyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-(aminocarbonyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3,5-dimethylphenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3,5-dichlorophenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(2-(1-methylethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-(1,1-dimethylethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(1-naphthalenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-(ethyloxy)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-(1,1-dimethylethyl)cyclohexyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(2-methyl-5-(1-piperidinylcarbonyl)phenyl)-3-(4-pyrimidinyl)-2-pyridinamine;

4-methyl-N-phenyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(5-chloro-2-(methyloxy)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(3-(phenylcarbonyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(cyclopropylmethyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3,3-dimethylbutyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(2-thienylmethyl)benzamide;

N-(cyclohexylmethyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(2,3-dihydro-1H-inden-4-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(3-((1-methylethyl)oxy)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-chlorophenyl)-N,4-dimethyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N,4-dimethyl-N-phenyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(2-bromo-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N,4-dimethyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide;

2-chloro-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)-5-(trifluoromethyl)benzamide;

3-chloro-2-fluoro-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)-5-(trifluoromethyl)benzamide;

4-methyl-N-(2-(methylsulfanyl)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(2-((4-(methyloxy)phenyl)oxy)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(2-nitro-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(5-(1,1-dimethylethyl)-2-(methyloxy)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(4-(4-morpholinyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-(acetylamino)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-(diethylamino)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-hydroxyphenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(4-(1-piperidinyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-(1H-imidazol-1-yl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(4-(1-methylethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

1,1-dimethylethyl (2S)-2-(((3-(((4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)carbonyl)amino)-5-(trifluoromethyl)phenyl)oxy)methyl)-1-pyrrolidinecarboxylate;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(3-(((2S)-2-pyrrolidinylmethyl)oxy)-5-(trifluoromethyl)phenyl)benzamide;

4-methyl-N-(3-((2-(1-piperidinyl)ethyl)oxy)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(6-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-2-pyridinyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(6-(4-ethyl-1-piperazinyl)-2-pyridinyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(6-(1-pyrrolidinylmethyl)-2-pyridinyl)benzamide;

4-methyl-N-(3-(4-morpholinylmethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(diphenylmethyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(4-(methyloxy)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(1-methyl-1-phenylethyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(4-(4-methyl-1-piperazinyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(4-pyridinyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-(acetyl(methyl)amino)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-fluoro-3-(4-morpholinylmethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-fluoro-3-(hydroxymethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(6-(1-piperidinylmethyl)-2-pyridinyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-N-(4-(4-pyridinyloxy)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide;

N-(3-((1-methylethyl)oxy)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)-N-(4-(1H-1,2,4-triazol-1-yl)phenyl)benzamide;

N-(5-(((3R,5S)-3,5-dimethyl-1-piperazinyl)carbonyl)-2-methylphenyl)-3-(4-pyrimidinyl)-2-pyridinamine;

N-(5-(((2R,6S)-2,6-dimethyl-1-piperidinyl)carbonyl)-2-methylphenyl)-3-(4-pyrimidinyl)-2-pyridinamine;

1,1-dimethylethyl 2-((3-(((4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)carbonyl)amino)-5-(trifluoromethyl)phenyl)oxy)ethylcarbamate;

N-(3-((2-aminoethyl)oxy)-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-(2-hydroxyethyl)phenyl)-4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide;

4-chloro-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide;

4-chloro-N-(3-chlorophenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide;

N-(4-tert-butylphenyl)-4-chloro-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide;

4-chloro-N-(4-(dimethylamino)phenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide;

4-chloro-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N-(3-((S)-pyrrolidin-2-ylmethoxy)-5-(trifluoromethyl)phenyl)benzamide;

4-methyl-N-(3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(3-((2-chloroethyl)oxy)-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)amino)-N-(3-(1-methylethyl)phenyl)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

3-((3-(2-((2-(diethylamino)ethyl)amino)-4-pyrimidinyl)-2-pyridinyl)amino)-4-methyl-N-(3-(1-methylethyl)phenyl)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-4-methyl-3-((3-(6-(methylamino)-4-pyrimidinyl)-2-pyridinyl)amino)benzamide;

N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)-3-(trifluoromethyl)benzenesulfonamide;

2,3-dichloro-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)benzenesulfonamide;

N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)-3,5-bis(trifluoromethyl)benzenesulfonamide;

N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)benzenesulfonamide;

N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)benzamide;

N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(2-fluoro-3-(trifluoromethyl)phenyl)-N′-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)urea;

N-(2-fluoro-5-(trifluoromethyl)phenyl)-N′-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)urea;

N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)-3-(trifluoromethyl)benzamide;

2,3-dichloro-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)benzamide;

3-methyl-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)cyclohexanecarboxamide;

1-ethyl-3-methyl-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)-1H-pyrazole-5-carboxamide;

3,5-dichloro-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)amino)phenyl)benzamide;

3-(trifluoromethyl)-N-(2,4,6-trimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)benzamide;

N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide;

3-chloro-N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)benzamide;

3-chloro-N-(4-methoxy-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)benzamide;

3-(trifluoromethyl)-N-(2,4,6-trimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)benzamide;

N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide;

3-chloro-N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)benzamide;

3-chloro-N-(4-methoxy-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)benzamide;

4-methyl-N-(3-(2-morpholinoethoxy)-5-(trifluoromethyl)phenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide;

N-(3-(2-(2-((isopropylamino)methyl)pyrrolidin-1-yl)ethoxy)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide;

N-(3-(2-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)ethoxy)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide;

tert-butyl 4-(2-(3-(4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamido)-5-(trifluoromethyl)phenoxy)ethyl)piperazine-1-carboxylate;

4-methyl-N-(3-(2-(piperazin-1-yl)ethoxy)-5-(trifluoromethyl)phenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide;

3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N-(3-((S)-pyrrolidin-2-ylmethoxy)-5-(trifluoromethyl)phenyl)-4-(trifluoromethyl)benzamide;

N-(3-chlorophenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-4-(trifluoromethyl)benzamide;

N-(3-isopropylphenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-4-(trifluoromethyl)benzamide;

N-(4-tert-butylphenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-4-(trifluoromethyl)benzamide;

N-(3-(dimethylamino)phenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-4-(trifluoromethyl)benzamide;

N-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-4-(trifluoromethyl)benzamide;

N-(2,3-dihydro-1H-inden-5-yl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-4-(trifluoromethyl)benzamide;

N-(3-methoxyphenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-4-(trifluoromethyl)benzamide;

N-(3-isopropoxyphenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-4-(trifluoromethyl)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-((1S)-1,2,2-trimethylpropyl)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-((1R)-1,2,2-trimethylpropyl)benzamide;

N-(3-(dimethylamino)-2,2-dimethylpropyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(5-(1,1-dimethylethyl)-2-(methyloxy)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-chloro-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(1-pyrrolidinyl)-5-(trifluoromethyl)phenyl)benzamide;

4-methyl-N-(2-(methylsulfanyl)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-bromo-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2,5-dichlorophenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(2-(4-morpholinyl)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(4-(methyloxy)-1,1′-biphenyl-3-yl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

methyl 4-(methyloxy)-3-(((4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)carbonyl)amino)benzoate;

N-(2,5-bis(methyloxy)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(2-methyl-5-(methyloxy)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(1,1′-biphenyl-3-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

4-methyl-N-(2-(methyloxy)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(4-(methyloxy)-1,1′-biphenyl-3-yl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((((2R)-1-methyl-2-pyrrolidinyl)methyl)oxy)-5-(trifluoromethyl)phenyl)benzamide;

4-methyl-N-(2-methyl-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(2-methyl-5-(1-methylethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-methyl-N-(4-(1-methylethyl)phenyl)-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-methyl-N-(3-(1-methylethyl)phenyl)-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(2-methyl-3,5-bis(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyloxy)phenyl)benzamide;

N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(4-morpholinyl)-5-(trifluoromethyl)phenyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-((1R)-1-phenylethyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-((1S)-1-phenylethyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-phenylbenzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(4-(1-methylethyl)phenyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-methyl-3-(trifluoromethyl)phenyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((phenylmethyl)oxy)phenyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-propylbenzamide;

N-(2-hydroxyethyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-((3-(2-((2-(diethylamino)ethyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)-4-methyl-N-(3-(1-methylethyl)phenyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(phenylmethyl)phenyl)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-3-((3-(2-((2-(diethylamino)ethyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)-4-methylbenzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-((3-(trifluoromethyl)phenyl)methyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2,2,3,3,3-pentafluoropropyl)benzamide;

N-(2,2,3,3,4,4,4-heptafluorobutyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-((1S)-1-cyclohexylethyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-((1R)-1-cyclohexylethyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(5-(1,1-dimethylethyl)-2-(methyloxy)phenyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-((3-(2-((2-(diethylamino)ethyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)-4-methyl-N-(2-(4-morpholinyl)-5-(trifluoromethyl)phenyl)benzamide;

N-(5-(1,1-dimethylpropyl)-2-(methyloxy)phenyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-butyl-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-pentylbenzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-phenylbenzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-5-(trifluoromethyl)phenyl)benzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyloxy)phenyl)benzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(4-(1-methylethyl)phenyl)benzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-methyl-3-(trifluoromethyl)phenyl)benzamide;

4-chloro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-phenylbenzamide;

4-chloro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

4-chloro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)benzamide;

4-chloro-N-(5-cyclohexyl-2-(methyloxy)phenyl)-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-chloro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-5-(trifluoromethyl)phenyl)benzamide;

4-chloro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyloxy)phenyl)benzamide;

4-chloro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(4-(1-methylethyl)phenyl)benzamide;

4-chloro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-methyl-3-(trifluoromethyl)phenyl)benzamide;

4-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-phenylbenzamide;

4-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

4-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-4-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-5-(trifluoromethyl)phenyl)benzamide;

4-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyloxy)phenyl)benzamide;

4-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(4-(1-methylethyl)phenyl)benzamide;

4-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-methyl-3-(trifluoromethyl)phenyl)benzamide;

2-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-phenylbenzamide;

2-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

2-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-2-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

2-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-5-(trifluoromethyl)phenyl)benzamide;

2-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyloxy)phenyl)benzamide;

2-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(4-(1-methylethyl)phenyl)benzamide;

2-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-methyl-3-(trifluoromethyl)phenyl)benzamide;

2-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-phenylbenzamide;

2-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

2-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-2-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

2-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-5-(trifluoromethyl)phenyl)benzamide;

2-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyloxy)phenyl)benzamide;

2-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(4-(1-methylethyl)phenyl)benzamide;

2-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-methyl-3-(trifluoromethyl)phenyl)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-phenylbenzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-5-(trifluoromethyl)phenyl)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyloxy)phenyl)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(4-(1-methylethyl)phenyl)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-methyl-3-(trifluoromethyl)phenyl)benzamide;

N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl)benzamide;

N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)-N-(3-(trifluoromethyl)phenyl)benzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)-N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)benzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)-N-(4-(1-methylethyl)phenyl)benzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)-N-(2-(methyloxy)phenyl)benzamide;

N,4-dimethyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-((2-(1-pyrrolidinyl)ethyl)oxy)-5-(trifluoromethyl)phenyl)benzamide;

N-methyl-4-(2-((2-methyl-5-((6-(trifluoromethyl)-2,3-dihydro-1H-indol-1-yl)carbonyl)phenyl)oxy)-3-pyridinyl)-2-pyrimidinamine;

N-methyl-4-(2-((2-methyl-5-((7-(trifluoromethyl)-3,4-dihydro-1(2H)-quinolinyl)carbonyl)phenyl)oxy)-3-pyridinyl)-2-pyrimidinamine;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(1-pyrrolidinyl)-5-(trifluoromethyl)phenyl)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-((4-methyl-1-piperazinyl)methyl)-5-(trifluoromethyl)phenyl)benzamide;

N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((trifluoromethyl)oxy)phenyl)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((1-methylethyl)oxy)phenyl)benzamide;

N-(2-((3R)-3-(dimethylamino)-1-pyrrolidinyl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-((3S)-3-(dimethylamino)-1-pyrrolidinyl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-((3R)-3-(dimethylamino)-1-pyrrolidinyl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-((3S)-3-(dimethylamino)-1-pyrrolidinyl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-(((3R)-3-(dimethylamino)-1-pyrrolidinyl)methyl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-(((3S)-3-(dimethylamino)-1-pyrrolidinyl)methyl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyl(1-methyl-3-pyrrolidinyl)amino)-5-(trifluoromethyl)phenyl)benzamide;

2-methyl-6-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(1-methylethyl)phenyl)-4-pyridinecarboxamide;

2-methyl-6-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(methyloxy)-5-(trifluoromethyl)phenyl)-4-pyridinecarboxamide;

N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-2-fluoro-4-methyl-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-((3R)-3-(dimethylamino)-1-pyrrolidinyl)-5-(trifluoromethyl)phenyl)-2-fluoro-4-methyl-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyl(1-methyl-4-piperidinyl)amino)-5-(trifluoromethyl)phenyl)benzamide;

3-bromo-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(1-methylethyl)phenyl)benzamide;

3-bromo-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(methyloxy)-5-(trifluoromethyl)phenyl)benzamide;

2-fluoro-4-methyl-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyl(1-methyl-4-piperidinyl)amino)-5-(trifluoromethyl)phenyl)benzamide;

3-bromo-N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-bromo-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyl((1-methyl-3-pyrrolidinyl)amino)-5-(trifluoromethyl)phenyl)benzamide;

3-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(1-methylethyl)phenyl)benzamide;

3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(1-methylethyl)phenyl)benzamide;

2-fluoro-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(1-methylethyl)phenyl)benzamide;

2-fluoro-4-methyl-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyl(1-methyl-3-pyrrolidinyl)amino)-5-(trifluoromethyl)phenyl)benzamide;

3-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(methyloxy)-5-(trifluoromethyl)phenyl)benzamide;

3-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyl(1-methyl-3-pyrrolidinyl)amino)-5-(trifluoromethyl)phenyl)benzamide;

N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-3-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(1-methylethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(1-methylethyl)phenyl)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyl((3R)-1-methyl-3-pyrrolidinyl)amino)-5-(trifluoromethyl)phenyl)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(methyl(1-methyl-3-pyrrolidinyl)amino)-5-(trifluoromethyl)phenyl)benzamide;

N-(2-(2-(dimethylamino)-1,1-dimethylethyl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(1,1-dimethylethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-phenyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-fluorophenyl)-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-fluoro-2-(methyloxy)phenyl)-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-ethynylphenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(pentafluoroethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(5-bromo-2-((3-(dimethylamino)propyl)(methyl)amino)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-chloro-2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(5-chloro-2-((3-(dimethylamino)propyl)(methyl)amino)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(5-cyclopropyl-2-((3-(dimethylamino)propyl)(methyl)amino)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(5-chloro-2-(methyl(1-methyl-3-pyrrolidinyl)amino)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-((dimethylamino)methyl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((4-methyl-1-piperazinyl)methyl)-5-(trifluoromethyl)phenyl)benzamide;

N-(3-((1,1-dioxido-4-thiomorpholinyl)carbonyl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

2-fluoro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-((4-methyl-1-piperazinyl)methyl)-5-(trifluoromethyl)phenyl)benzamide;

2-fluoro-N-(2-((2-imino-1,3-oxazolidin-3-yl)methyl)-5-(trifluoromethyl)phenyl)-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-bromophenyl)-2-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)acetamide;

N-(3-fluorophenyl)-2-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)acetamide;

N-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)acetamide;

3-(((4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)acetyl)amino)benzamide;

2-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N-(5-methyl-3-isoxazolyl)acetamide;

N-(3-isoxazolyl)-2-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)acetamide;

2-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N-(5-methyl-1H-pyrazol-3-yl)acetamide;

2-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N-(3-pyridinyl)acetamide;

2-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N-(4-pyridinyl)acetamide;

N-methyl-3-(((4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)acetyl)amino)benzamide;

N-(4-chlorophenyl)-2-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)acetamide;

N-cyclopropyl-4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(4-(1,1-dimethylethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(1,1-dimethylethyl)-1-methyl-1H-pyrazol-5-yl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(5-(1,1-dimethylethyl)-3-isoxazolyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-(4-(trifluoromethyl)phenyl)benzamide;

N-(3-chlorophenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2,3-dihydro-1H-inden-5-yl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-((3-(trifluoromethyl)phenyl)methyl)benzamide;

N-(1H-indazol-5-yl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(1H-indazol-6-yl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

N-(4-(1,1-dimethylethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(1,1-dimethylethyl)-1-methyl-1H-pyrazol-5-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-(4-(trifluoromethyl)phenyl)benzamide;

N-(2,3-dihydro-1H-inden-5-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-((3-(trifluoromethyl)phenyl)methyl)benzamide;

N-(1H-indazol-5-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(1H-indazol-6-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-((1S)-1-cyclohexylethyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(dimethylamino)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(4-chloro-3-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-amino-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-((2-(trifluoromethyl)phenyl)methyl)benzamide;

N-(3-(hydroxymethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3,4-dimethylphenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-((4-(trifluoromethyl)phenyl)methyl)benzamide;

N-(4-(aminocarbonyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(1,1-dimethylethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(1-naphthalenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-phenyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3,3-dimethylbutyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-chlorophenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(dimethylamino)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(4-chloro-3-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-((1S)-1-cyclohexylethyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-((2-(trifluoromethyl)phenyl)methyl)benzamide;

N-(3,5-dichlorophenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-fluoro-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2-methyl-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3,5-dimethylphenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(1-methylethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(4-fluoro-3-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-chloro-4-fluorophenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(4-(methyloxy)-3-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(ethyloxy)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2,3-dihydro-1H-inden-4-yl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-((1-methylethyl)oxy)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(4-nitro-3-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(methyloxy)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-(2-((5-(((2R,6S)-2,6-dimethyl-1-piperidinyl)carbonyl)-2-methylphenyl)oxy)-3-pyridinyl)pyrimidine;

N-(3,5-dimethylphenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(1,1-dimethylethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-phenyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(3-(1-methylethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(ethyloxy)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(2,3-dihydro-1H-inden-4-yl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3-(4-morpholinylmethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(3,4-dimethylphenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-((4-(trifluoromethyl)phenyl)methyl)benzamide;

N-(3-(aminocarbonyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(1-naphthalenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(4-fluoro-3-(trifluoromethyl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(3-((1-methylethyl)oxy)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(4-(4-morpholinyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(4-(diethylamino)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(4-(1-piperidinyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(4-(1H-imidazol-1-yl)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(4-(4-methyl-1-piperazinyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(4-(acetyl(methyl)amino)phenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-N-(4-(1H-1,2,4-triazol-1-yl)phenyl)benzamide;

4-methyl-N-(4-pyridinyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

N-(4-hydroxyphenyl)-4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide;

4-methyl-N-(3-(piperidin-4-yloxy)-5-(trifluoromethyl)phenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)benzamide;

tert-butyl 4-(3-(4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)benzamido)-5-(trifluoromethyl)phenoxy)piperidine-1-carboxylate;

4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

3-((5-chloro-3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-4-methyl-N-(3-(1-methylethyl)phenyl)benzamide;

3-((3-(5-fluoro-2-((2-(1-pyrrolidinyl)ethyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)-4-methyl-N-(3-(1-ethylethyl)phenyl)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-3-((3-(5-fluoro-2-((2-(1-pyrrolidinyl)ethyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)-4-methylbenzamide;

3-((3-(5-fluoro-2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-4-methyl-N-(3-(1-methylethyl)phenyl)benzamide;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-3-((3-(5-fluoro-2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-4-methylbenzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(3-(1-methylethyl)phenyl)benzamide;

3-((5-bromo-3-(4-pyrimidinyl)-2-pyridinyl)oxy)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide;

N-(2-fluoro-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-fluoro-3-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-phenyl-N′-(4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)urea;

N-(2,5-dimethyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(2,5-dimethyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-phenylurea;

N-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzenesulfonamide;

N-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzenesulfonamide;

N-(2-chloro-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-chloro-2-(methyloxy)phenyl)-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3,5-bis(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

2,3-dichloro-N-(4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)benzenesulfonamide;

N-(4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)-3-(trifluoromethyl)benzenesulfonamide;

N-(2-fluoro-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-phenyl-N′-(4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

2,3-dichloro-N-(4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzenesulfonamide;

N-(2-fluoro-5-(trifluoromethyl)phenyl)-N′-(4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)urea;

N-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-indole-2-carboxamide;

N-(3,5-dichloro-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(2-chloro-5-(trifluoromethyl)phenyl)-N′-(4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)urea;

N-(8-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-5-quinolinyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(2-chloro-5-(trifluoromethyl)phenyl)-N′-(8-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-5-quinolinyl)urea;

3,5-dichloro-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

3-chloro-2-fluoro-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-5-(trifluoromethyl)benzamide;

2-chloro-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-5-(trifluoromethyl)benzamide;

3-(1,1-dimethylethyl)-1-methyl-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-pyrazole-5-carboxamide;

N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-((trifluoromethyl)oxy)benzamide;

N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3,5-bis(trifluoromethyl)benzamide;

N-(3,5-bis(trifluoromethyl)phenyl)-N′-(8-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-5-quinolinyl)urea;

N-(8-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-5-quinolinyl)-N′-(4-(trifluoromethyl)phenyl)urea;

N-(8-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-5-quinolinyl)-2-(3-(trifluoromethyl)phenyl)acetamide;

N-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-((trifluoromethyl)sulfanyl)phenyl)urea;

N-(3-bromophenyl)-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-fluoro-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(5-cyclohexyl-2-(methyloxy)phenyl)-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)benzamide;

N-(2-fluoro-5-(trifluoromethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)urea;

N-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-fluoro-5-(trifluoromethyl)phenyl)urea;

N-(3,5-bis(trifluoromethyl)phenyl)-N′-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-butyl-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

5-(1,1-dimethylethyl)-2-(methyloxy)-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

5-(1,1-dimethylethyl)-N-(4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-(methyloxy)benzamide;

N-(4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-((trifluoromethyl)oxy)benzamide;

N-(4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-((1,1,2,2-tetrafluoroethyl)oxy)benzamide;

N-(4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzenesulfonamide;

2,3-dichloro-N-(4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzenesulfonamide;

2-chloro-N-(4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-5-(trifluoromethyl)benzamide;

3-(1,1-dimethylethyl)-1-methyl-N-(4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-pyrazole-5-carboxamide;

N-(2-chloro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-((1,1,2,2-tetrafluoroethyl)oxy)benzamide;

2-bromo-N-(4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-5-(methyloxy)benzamide;

N-(2-chloro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

2-chloro-N-(2-chloro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-5-(trifluoromethyl)benzamide;

N-(2,4-dichloro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-((1,1,2,2-tetrafluoroethyl)oxy)benzamide;

2-bromo-N-(2-chloro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-5-(methyloxy)benzamide;

N-(2-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-((1,1,2,2-tetrafluoroethyl)oxy)benzamide;

2-chloro-N-(2-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-5-(trifluoromethyl)benzamide;

2-chloro-N-(2,4-dichloro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-5-(trifluoromethyl)benzamide;

3,5-dichloro-N-(4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

5-(1,1-dimethylethyl)-N-(3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-5-(trifluoromethyl)phenyl)-2-(methyloxy)benzamide;

N-(3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-5-(trifluoromethyl)phenyl)-3-((1,1,2,2-tetrafluoroethyl)oxy)benzamide;

3,5-dichloro-N-(3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-5-(trifluoromethyl)phenyl)benzamide;

N-(3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-5-(trifluoromethyl)phenyl)-3-(trifluoromethyl)benzamide;

N-(3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-5-(trifluoromethyl)phenyl)-3-(1-methylethyl)benzamide;

3-(1-methylethyl)-N-(4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

N-(3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(1-methylethyl)benzamide;

5-(1,1-dimethylethyl)-N-(3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-(methyloxy)benzamide;

N-(3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-((1,1,2,2-tetrafluoroethyl)oxy)benzamide;

3,5-dichloro-N-(3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

3-(dimethylamino)-N-(3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-5-(trifluoromethyl)phenyl)benzamide;

N-(2-chloro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(1-methylethyl)benzamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-phenylurea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-phenylacetamide;

phenyl 3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenylcarbamate;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

N-(3-chlorophenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-chlorophenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-chlorophenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-methylphenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(methyloxy)phenyl)urea;

N-(3-cyanophenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-ethyl-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-cyclohexyl-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-cyclopentyl-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(phenylmethyl)urea;

N-(3-fluorophenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)thiourea;

N-(2-chloro-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-chloro-2-(methyloxy)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-fluoro-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3,5-bis(methyloxy)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-phenylthiourea;

N-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)thiourea;

N-(3-bromophenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(1,3-benzodioxol-5-yl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-indole-2-carboxamide;

N-(2,5-dichlorophenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3,5-dichlorophenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-chloro-2-methylphenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-(3-(trifluoromethyl)phenyl)acetamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

5-chloro-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-indole-2-carboxamide;

N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-((2-(1-pyrrolidinyl)ethyl)oxy)-5-(trifluoromethyl)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-(methyl(1-methyl-3-pyrrolidinyl)amino)-5-(trifluoromethyl)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-((4-methyl-1-piperazinyl)methyl)-5-(trifluoromethyl)phenyl)urea;

N-(3-(ethyloxy)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2,5-bis(1,1-dimethylethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-(1,1-dimethylethyl)-2-(methyloxy)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-chloro-2-((3-(dimethylamino)propyl)(methyl)amino)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-((3-methylphenyl)methyl)urea;

N-(5-bromo-2-((3-(dimethylamino)propyl)(methyl)amino)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-((3-(dimethylamino)propyl)oxy)-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(1-methyl-4-piperidinyl)-5-(trifluoromethyl)phenyl)urea;

N-(5-chloro-2-(methyl(1-methyl-3-pyrrolidinyl)amino)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(5-methyl-2-(methyloxy)phenyl)urea;

N-(2,5-dimethylphenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-ethylphenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-chloro-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(5-chloro-2-(methyloxy)phenyl)urea;

N-(3-chloro-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-fluoro-5-(trifluoromethyl)phenyl)urea;

N-(3-chloro-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-fluoro-5-(trifluoromethyl)phenyl)urea;

N-(3-chloro-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-((4-methyl-1-piperazinyl)methyl)-5-(trifluoromethyl)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-((4-methyl-1-piperazinyl)carbonyl)-5-(trifluoromethyl)phenyl)urea;

N-(3-chloro-2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-(1,1-dimethylethyl)-3-isoxazolyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-(4-morpholinyl)-5-(trifluoromethyl)phenyl)urea;

N-(4-ethyl-2-pyridinyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-7-(trifluoromethyl)-3,4-dihydro-1(2H)-quinolinecarboxamide;

N-(3,4-dimethyl-5-isoxazolyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-((dimethylamino)methyl)-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-ethynylphenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-((1,1-dioxido-4-thiomorpholinyl)carbonyl)-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-((3-(dimethylamino)propyl)oxy)-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2,3-dimethylphenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-chloro-4-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-chloro-3-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-chloro-2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-chloro-2-((3-(dimethylamino)propyl)(methyl)amino)phenyl)-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-chloro-2,4-bis(methyloxy)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2,5-bis(methyloxy)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-cyclopropyl-2-((3-(dimethylamino)propyl)(methyl)amino)phenyl)-N′-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-cyclopropyl-2-((3-(dimethylamino)propyl)(methyl)amino)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-chloro-2-(methyloxy)phenyl)-N′-(3-methyl-4-((3-(2-((3-(4-morpholinyl)propyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-chloro-4-fluorophenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-fluoro-2-methylphenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2,4,5-trichlorophenyl)urea;

N-(5-chloro-2-(methyloxy)phenyl)-N′-(3-methyl-4-((3-(2-((3-(2-oxo-1-pyrrolidinyl)propyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-((3-(2-oxo-1-pyrrolidinyl)propyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-((trifluoromethyl)sulfanyl)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-((trifluoromethyl)sulfanyl)phenyl)thiourea;

N-(5-chloro-2-(methyloxy)phenyl)-N′-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-chlorophenyl)-N′-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-fluoro-5-(trifluoromethyl)phenyl)urea;

N-(2-chloro-5-(trifluoromethyl)phenyl)-N′-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-chloro-2,4-bis(methyloxy)phenyl)-N′-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(4-(trifluoromethyl)-2-pyridinyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-(methyloxy)-5-(trifluoromethyl)phenyl)urea;

N-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-(methyloxy)-5-(trifluoromethyl)phenyl)urea;

N-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-fluorophenyl)urea;

N-(3-fluorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-cyclopropyl-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-chloro-2-(methyloxy)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(5-chloro-2,4-bis(methyloxy)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-bromophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-chloro-5-(trifluoromethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-chlorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-fluoro-5-(trifluoromethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-(methyl((2S)-1-methyl-2-pyrrolidinyl)amino)-5-(trifluoromethyl)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-(methyl((3R)-1-methyl-3-pyrrolidinyl)amino)-5-(trifluoromethyl)phenyl)urea;

N-(5-chloro-2-(methyloxy)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)urea;

N-(3-chlorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)urea;

N-(3-fluoro-5-(trifluoromethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)urea;

N-(3-bromophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)urea;

N-(3-fluorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-phenylurea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)-N′-phenylurea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

3-bromo-N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(2,5-bis(1,1-dimethylethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)urea;

N-(2-chloro-5-(trifluoromethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-thiophenecarboxamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-furancarboxamide;

N-(2-fluorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-fluorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(4-((3-(5-fluoro-2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-phenylurea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-((trifluoromethyl)sulfanyl)phenyl)urea;

N-(3-cyanophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

ethyl 3-((((4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)amino)carbonyl)amino)benzoate;

ethyl 4-((((4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)amino)carbonyl)amino)benzoate;

N-(2-bromophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-(ethyloxy)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-bromophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)urea;

N-(2-(ethyloxy)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)urea;

N-(4-((3-(5-fluoro-2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

2-chloro-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

3-chloro-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

4-chloro-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

N-(2-chlorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-chlorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)-3-(trifluoromethyl)benzamide;

3-chloro-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-thiophenecarboxamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1-benzothiophene-2-carboxamide;

3-chloro-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1-benzothiophene-2-carboxamide;

3-(1,1-dimethylethyl)-1-methyl-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-pyrazole-5-carboxamide;

3-methyl-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-thiophenecarboxamide;

5-chloro-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-thiophenecarboxamide;

5-methyl-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-thiophenecarboxamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-quinolinecarboxamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-pyridinecarboxamide;

3-bromo-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2-(trifluoromethyl)phenyl)urea;

N-(3-chloro-4-fluorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3,4-difluorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-phenylurea;

N-(4-chlorophenyl)-N′-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

3-bromo-N-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

N-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-naphthalenecarboxamide;

N-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-phenylurea;

N-(4-chlorophenyl)-N′-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-thiophenecarboxamide;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(4-((trifluoromethyl)sulfanyl)phenyl)urea;

N-(4-fluorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-fluoro-4-methylphenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(4-(1-methylethyl)phenyl)urea;

3-(1,1-dimethylethyl)-1-methyl-N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-pyrazole-5-carboxamide;

N-(4-cyanophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-bromophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(4-(phenyloxy)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3,4,5-tris(methyloxy)phenyl)urea;

N-(2-fluoro-3-(trifluoromethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-oxo-2-phenylacetamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-benzimidazole-5-carboxamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-1,2,3-benzotriazole-5-carboxamide;

6-hydroxy-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-pyridinecarboxamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-pyridinecarboxamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1-naphthalenecarboxamide;

2-methyl-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-benzimidazole-5-carboxamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-6-quinolinecarboxamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-indole-5-carboxamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-indole-6-carboxamide;

N-(4-chloro-3-(trifluoromethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-(dimethylamino)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(1H-pyrrol-1-yl)benzamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(phenyloxy)benzamide;

N-(3-chloro-4-(methyloxy)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3,5-dichlorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-fluoro-3-(trifluoromethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(phenyloxy)benzamide;

N-(4-chlorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)-N′-(4-(1-methylethyl)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(1H-pyrrol-1-yl)benzamide;

1-methyl-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-indole-2-carboxamide;

1-ethyl-3-methyl-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-pyrazole-5-carboxamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1-benzothiophene-3-carboxamide;

4-cyclohexyl-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-phenylthiourea;

N-(3-ethylphenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-chloro-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-fluoro-4-methylphenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-oxo-2-phenylacetamide;

N-(4-(1,1-dimethylethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-(ethyloxy)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(2,4,5-trichlorophenyl)urea;

N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-(phenyloxy)benzamide;

1,1-dimethylethyl 2-((3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)amino)-2-oxo-1-phenylethylcarbamate;

N-(3-fluoro-4-(methyloxy)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-fluoro-4-(methyloxy)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

4-chloro-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-((trifluoromethyl)oxy)benzamide;

N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-((phenylmethyl)oxy)benzamide;

2-cyclohexyl-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)acetamide;

N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)hexanamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(3-thienyl)benzamide;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(5-methyl-1H-pyrazol-3-yl)urea;

N-(1-ethyl-1H-pyrazol-5-yl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-bromo-3-fluorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-bromo-3-fluorophenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-fluoro-4-((3-(4-methyl-1-piperazinyl)propyl)oxy)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(1-pyrrolidinyl)benzamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(2-thienyl)benzamide;

N-(2-(diethylamino)ethyl)-2-fluoro-4-((((4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)amino)carbonyl)amino)benzamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(phenylmethyl)-2-morpholinecarboxamide;

3-fluoro-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-5-(trifluoromethyl)benzamide;

4-fluoro-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(4-chlorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)sulfinyl)phenyl)urea;

N-(1,1′-biphenyl-4-yl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(4-((1-methyl-4-piperidinyl)oxy)phenyl)urea;

N-(4-(2-(3,4-dimethyl-1-piperazinyl)ethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-fluoro-4-((3-(1H-imidazol-1-yl)propyl)oxy)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-ethyl-4-methylphenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-ethyl-4-methylphenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-fluoro-4-methylphenyl)-N′-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-bromophenyl)-N′-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-fluoro-4-(methyloxy)phenyl)-N′-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-bromo-3-fluorophenyl)-N′-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-chloro-3-fluorophenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-chloro-3-fluorophenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

3-((3S)-3-(dimethylamino)-1-pyrrolidinyl)-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)-N′-phenylurea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-1-piperazinyl)benzamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-indole-7-carboxamide;

N-(2,3-dihydro-1H-inden-5-yl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(9H-fluoren-2-yl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(2,3-dihydro-1H-inden-5-yl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(4-(trifluoromethyl)phenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(4-(trifluoromethyl)phenyl)urea;

N-(3-fluoro-4-methylphenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-((trifluoromethyl)oxy)benzamide;

4-chloro-N-(3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-((trifluoromethyl)oxy)benzamide;

N-(3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

4-((phenylmethyl)oxy)-N-(3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

2-cyclohexyl-N-(3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)acetamide;

N-(3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)hexanamide;

4-(dimethylamino)-N-(3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

3-(1,1-dimethylethyl)-1-methyl-N-(3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-1H-pyrazole-5-carboxamide;

4,4-dimethyl-N-(3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)pentanamide;

4,4-dimethyl-N-(4-methyl-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)pentanamide;

4-((4-methyl-1-piperazinyl)methyl)-N-(3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

N-(9H-fluoren-2-yl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(1-acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(1-acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-(1,1-dimethylethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-(1,1-dimethylethyl)phenyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-(1,1-dimethylethyl)phenyl)-N′-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-(1,1-dimethylethyl)phenyl)-N′-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(1,1-dimethylethyl)-N′-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-(3-fluoro-4-methylphenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)urea;

N-(4-(1,1-dimethylethyl)phenyl)-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)urea;

N-(4-((3-(2-(phenylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(3-methyl-4-((3-(2-((4-(4-methyl-1-piperazinyl)phenyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)acetamide;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(4-methylphenyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(4-methylphenyl)urea;

N-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(4-methylphenyl)urea;

N-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(4-methylphenyl)urea;

N-(4-((3-(2-((4-(4-methyl-1-piperazinyl)phenyl)amino)-4-pyrimidinyl)-2-pyridinyl)sulfanyl)phenyl)-3-(trifluoromethyl)benzamide;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(phenylmethyl)urea;

N-(2-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(phenylmethyl)urea;

N-(2,3-dimethyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(phenylmethyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)-N′-(phenylmethyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-((3-methylphenyl)methyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-((2-methylphenyl)methyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-((2-methylphenyl)methyl)urea;

N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-((4-methylphenyl)methyl)urea;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-((4-methylphenyl)methyl)urea;

N-(4-chlorophenyl)-N′-(4-((3-(2-((3-(4-morpholinyl)propyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

1-(1-acetylindolin-6-yl)-3-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)urea;

1-(4-tert-butylphenyl)-3-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)urea;

1-(4-isopropylphenyl)-3-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)urea;

1-(2,3-dihydro-1H-inden-5-yl)-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)urea;

1-(2,3-dihydro-1H-inden-5-yl)-3-(4-(3-(2-(3-morpholinopropylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)urea;

1-(3-fluoro-4-methylphenyl)-3-(4-(3-(2-(3-morpholinopropylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)urea;

1-(3-methyl-4-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-phenylurea;

1-(3-methyl-4-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(4-methylbenzyl)urea;

N-(3-methyl-4-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(thiophen-2-yl)benzamide;

N-(1,1-dimethylethyl)-N′-(3-methyl-4-((3-(2-((4-(4-methyl-1-piperazinyl)phenyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

N-ethyl-N′-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-1-naphthalenyl)urea;

N-(3-methyl-4-((3-(2-((4-(4-methyl-1-piperazinyl)phenyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)cyclopropanecarboxamide;

N-(4-chlorophenyl)-N′-(3-methyl-4-((3-(2-((4-(4-methyl-1-piperazinyl)phenyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)urea;

1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)urea;

1-(4-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-phenylurea;

3-formyl-N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)benzamide;

1-(3-methyl-4-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(5-methylisoxazol-3-yl)urea;

1-(3-methyl-4-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(thiazol-2-yl)urea;

1-ethyl-3-(3-methyl-4-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)urea;

ethyl 4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenylcarbamoylcarbamate;

1-(4-chlorophenyl)-3-(4-(3-(2-(4-(4-methylpiperazin-1-yl)benzamido)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)urea;

1-(4-methoxyphenyl)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-oxopyrrolidine-3-carboxamide;

1-(2-fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-oxopyrrolidine-3-carboxamide;

N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-(phenylamino)benzamide;

1-(4-chlorophenyl)-3-(3-fluoro-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)urea;

1-(3-fluoro-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-phenylurea;

N-(3-fluoro-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(trifluoromethyl)benzamide;

1-(3-methoxy-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-phenylurea;

1-(4-chlorophenyl)-3-(3-methoxy-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)urea;

N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-5-phenylisoxazole-4-carboxamide;

N-(3-methoxy-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-(5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl)acetamide;

1-tert-butyl-3-(3-methoxy-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)urea;

1-benzoyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)thiourea;

N-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

N-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea;

N-(3-methyl-4-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N′-phenylurea;

N-(4-((3-(2-((2-(diethylamino)ethyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)-3-methylphenyl)-3-(trifluoromethyl)benzamide;

N-(4-((5-chloro-3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-3-methylphenyl)-3-(trifluoromethyl)benzamide;

N-(3-methyl-4-((3-(2-((1-methyl-4-piperidinyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(3-methyl-4-((3-(2-((3-(4-morpholinyl)propyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(3-methyl-4-((3-(2-(phenylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(3-methyl-4-((3-(2-((3-(4-methyl-1-piperazinyl)propyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(4-((3-(2-((2-(dimethylamino)ethyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)-3-methylphenyl)-3-(trifluoromethyl)benzamide;

N-(4-((3-(2-((4-(dimethylamino)butyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)-3-methylphenyl)-3-(trifluoromethyl)benzamide;

N-(4-((3-(2-((3-(dimethylamino)propyl)amino)-4-pyrimidinyl)-2-pyridinyl)oxy)-3-methylphenyl)-3-(trifluoromethyl)benzamide;

N-(3-methyl-4-(3-(2-(3-(pyrrolidin-1-yl)propylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(3-methyl-4-(3-(2-(3-(piperidin-1-yl)propylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(trifluoromethyl)benzamide;

4-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

3-methyl-4-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(3-(trifluoromethyl)phenyl)benzamide;

3-amino-N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

2-amino-N-(4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)benzamide;

N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)piperidine-4-carboxamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-5-(4-morpholinyl)-2-pyridinyl)oxy)-N-(3-(1-methylethyl)phenyl)benzamide;

4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-5-(4-methyl-1-piperazinyl)-2-pyridinyl)oxy)-N-(3-(1-methylethyl)phenyl)benzamide;

3-((5-((3-(dimethylamino)propyl)(methyl)amino)-3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-4-methyl-N-(3-(1-methylethyl)phenyl)benzamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-5-(4-methyl-1-piperazinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

2-(benzylamino)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)nicotinamide;

2-(cyclopropylamino)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)nicotinamide;

2-(cyclopropylmethylamino)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)nicotinamide;

2-(2-fluorophenylamino)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)nicotinamide;

2-(3-fluorophenylamino)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)nicotinamide;

2-(4-fluorophenylamino)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)nicotinamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-1-piperazinyl)-3-(trifluoromethyl)benzamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-((2-(4-morpholinyl)ethyl)amino)-3-(trifluoromethyl)benzamide;

4-((3-(dimethylamino)propyl)(methyl)amino)-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-((1-methyl-4-piperidinyl)amino)-3-(trifluoromethyl)benzamide;

N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-((3-(1-pyrrolidinyl)propyl)amino)-3-(trifluoromethyl)benzamide;

4-(dimethylamino)-N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-3-(trifluoromethyl)benzamide;

N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(trifluoromethyl)benzamide;

N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-chlorobenzamide;

N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-chlorobenzamide;

N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-methoxybenzamide;

4-tert-butyl-N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)phenyl)benzamide;

N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-methoxybenzamide;

N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-fluorobenzamide;

N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-methylbenzamide;

N-(2,4-dimethyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-methylbenzamide;

N-(2-chloro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)benzamide;

N-(2-chloro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-((3R)-3-(dimethylamino)-1-pyrrolidinyl)-5-(trifluoromethyl)benzamide; and

N-(2-chloro-5-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-2-((3S)-3-(dimethylamino)-1-pyrrolidinyl)-5-(trifluoromethyl)benzamide.

6. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective dosage amount of a compound of claim 1 .

7. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective dosage amount of a compound of claim 5 .

8. A method of treating a subject having breast, rheumatoid arthritis, or a combination thereof, the method comprising administering to the subject an effective dosage amount of a compound of claim 1 .

9. A method of treating a subject having cancer of the breast, rheumatoid arthritis, or a combination thereof, the method comprising administering to the subject an effective dosage amount of a pharmaceutical composition of claim 6 .

Continuity (3)

Continuation 11126000 · May 9, 2005

Provisional Application 60569193 · May 7, 2004

Related Publication 20110201602A1 · Aug 18, 2011