Methods and compositions for modulating P300/CBP activity

Inventors: Ronen Marmorstein (Swarthmore, PA); Xin Liu (Menlo Park, CA); Philip A. Cole (Baltimore, MD); Ling Wang (Seattle, WA); Erin M. Bowers (Baltimore, MD); David J. Meyers (Towson, MD); Chandrani Mukherjee (Baltimore, MD)

Assignees: The Wistar Institute; The John Hopkins University

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Quick Facts

Patent No.: US 8,476,458
App. No.: 12/665,751
Granted: Jul 2, 2013
Kind: B2

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Abstract

The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.

Claims (2)

1. A p300/CBP inhibitor selected from the group of:

2. A pharmaceutical composition comprising a p300/CBP inhibitor of claim 1 in admixture with a pharmaceutically acceptable carrier.

Assignments (3)

CONFIRMATORY LICENSE Recorded Jul 12, 2016

From: JOHNS HOPKINS UNIVERSITY

To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT

Reel/Frame 039311/0968 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 5, 2010

From: MARMORSTEIN, RONEN; LIU, XIN

To: THE WISTAR INSTITUTE

Reel/Frame 024338/0836 →