Patent
The present invention provides Withania somnifera plant extract and composition comprising the extract useful for the treatment of neurodegenerative disease and/or disorders such as Alzheimers disease (AD). The present invention further provides a process for preparation of the extract.
1. A Withania somnifera extract comprising about 70-80% withanolides and about 15-25% withanoside, wherein, the extract is prepared by a process comprising
providing Withania somnifera root powder;
extracting said root powder with a 1:1 ratio of methanol:chloroform mixture at room temperature for about 60-75 hours to obtain a root extract;
removing the methanol:chloroform from the root extract to obtain a dry root extract;
treating the dry root extract with a 10% methanol-chloroform mixture to obtain the Withania somnifera plant extract;
wherein the extract is free of withaferin.
2. The Withania somnifera extract as claimed in claim 1 , wherein the extract comprises 75% withanolides and 20% withanoside.
3. The Withania somnifera extract as claimed in claim 1 , wherein the extract is useful for the treatment of neurodegenerative disorders selected from a group consisting of Alzheimer's disease, Parkinson's disease and senile dementia.
4. The Withania somnifera extract as claimed in claim 1 , wherein the extract is in the form of powder, liquid, capsules or tablets.
5. The Withania somnifera extract as claimed in claim 1 , wherein the extract is useful for treatment of Alzheimer's disease.
6. The Withania somnifera extract as claimed in claim 4 , wherein effective dosage of the extract for the treatment of Alzheimer's disease is in the range of 0.5 g/day/kg body weight to 1 g/day/kg body weight.
7. A pharmaceutical composition comprising the Withania somnifera extract as claimed in claim 1 and a pharmaceutical acceptable carrier.
8. A nutritional composition comprising the Withania somnifera extract as claimed in claim 1 .
9. An herbal composition comprising the Withania somnifera extract as claimed in claim 1 .