Isoindole-imide compounds and compositions comprising and methods of using the same
This invention relates to isoindole-imide compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
1. A compound of formula I, or a pharmaceutically acceptable salt or stereoisomer thereof:
wherein:
X is O or S;
R 1 is H or methyl;
R 2 is NHR 4 ; and
R 4 is:
(C 3 -C 6 )cycloalkyl; or
phenyl substituted with (C 1 -C 4 )alkoxy.
2. The compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein X is S.
3. The compound of claim 1 , which is:
2
1-Cyclohexyl-3-[2-(2,6- dioxo-piperidin-3-yl)-1- oxo-2,3-dihydro-1H- isoindol-4-ylmethyl]-urea,
15
1-[2-(2,6-Dioxo-pipderidin- 3-yl)-1-oxo-2,3-dihydro- 1H-isoindol-4-ylmethyl]-3- (3-methoxy-phenyl)-urea,
16
1-[2-(2,6-Dioxo-piperidin- 3-yl)-1-oxo-2,3-dihydro- 1H-isoindol-4-ylmethyl]-3- (4-methoxy-phenyl)-urea,
17
1-[2-(2,6-Dioxo-piperidin- 3-yl)-1-oxo-2,3-dihydro- 1H-isoindol-4-ylmethyl]-3- (2-methoxy-phenyl)-urea,
35
1-Cyclohexyl-3-[2-(2,6- dioxo-piperidin-3-yl)-1- oxo-2,3-dihydro-1H- isoindol-4-ylmethyl]- thiourea,
4. A pharmaceutical composition comprising the compound of claim 1 .
5. The compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein X is O.