Methods and compositions for treating bacterial infection
The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against bacterial infections.
1. A pharmaceutical composition that inhibits the pathogenticity of Group A Streptococcus , comprising a compound that inhibits the expression or activity of streptokinase from said Group A Streptococcus , wherein said compound is selected from the group consisting of
2. The composition of claim 1 , further comprising a pharmaceutically acceptable carrier.
3. The composition of claim 1 , wherein said composition inhibits infectivity of said Group A Streptococcus.
4. The composition of claim 1 , wherein said composition further comprises a known antibiotic compound.
5. A method of inhibiting the pathogenticity of Group A Streptococcus , comprising contacting said Group A Streptococcus with a compound that inhibits the expression or activity of streptokinase from said Group A Streptococcus , wherein said compound is selected from the group consisting of
6. The method of claim 5 , wherein said composition inhibits infectivity of said Group A Streptococcus.
7. The method of claim 5 , further comprising the step of contacting said Group A Streptococcus with a known antibiotic compound.