Stabilized nicotine chewing gum
A nicotine chewing gum composition with improved stability.
1. A stable chewing gum composition comprising nicotine, a chewing gum base and a flavoring agent in a liquid carrier wherein the liquid carrier for the flavoring agent is a triglyceride and the chewing gum composition contains 0% to about 0.5% by weight based upon the total weight of the chewing gum composition of a liquid containing hydroxyl moieties that promote oxidation of nicotine free base; and wherein the chewing gum composition contains no more than 6% of trans nicotine-N-oxide and no more than 4% of cis nicotine-N-oxide when placed in a sealed plastic bottle and stored for four (4) weeks at 50° C. and 75% relative humidity.
2. The stable chewing gum composition as defined in claim 1 wherein the chewing gum composition is free of any liquid containing hydroxyl moieties that promote oxidation of nicotine free base.
3. The stable chewing gum composition as defined in claim 1 further comprising an organoleptic additive selected from the group consisting of a plasticizer, a buffering agent, a sweetener, a filler, a coloring agent and mixtures of the foregoing.
4. The stable chewing gum composition as defined in claim 1 that contains no more than 5% of the trans nicotine-N-oxide and no more than 3% of the cis nicotine-N-oxide.
5. The stable chewing gum composition as defined in claim 1 that contains no more than 4% of the trans nicotine-N-oxide and no more than 2.5% of the cis nicotine-N-oxide.
6. The stable chewing gum composition as defined in claim 1 that contains no more than 6% of the trans nicotine-N-oxide and no more than 3% of the cis nicotine-N-oxide when packaged in a foil backed blister package and stored for six months at 40° C. and 75% relative humidity.
7. The stable chewing gum composition as defined in claim 6 that contains no more than 5% of the trans nicotine-N-oxide and no more than 2.5% of the cis nicotine-N-oxide.
8. The stable chewing gum composition as defined in claim 6 that contains no more than 4% of the trans nicotine-N-oxide and no more than 2.0% of the cis nicotine-N-oxide.
9. A stable chewing gum composition as defined in claim 1 wherein the chewing gum composition comprises 0% to about 0.25% by weight based upon the total weight of the chewing gum composition of a liquid containing hydroxyl moieties.
10. A stable chewing gum composition comprising:
(a) Nicotine polacrilex;
(b) a chewing gum base;
(c) a flavoring agent in a hydrophobic liquid carrier wherein the hydrophobic liquid carrier is a triglyceride; and
(d) an organoleptic additive selected from the group consisting of a plasticizer, a buffering agent, a sweetener, a filler, a coloring agent and mixtures of the foregoing and wherein:
the chewing gum composition comprises 0% to about 0.5% by weight based upon the total weight of the chewing gum composition of a liquid containing hydroxyl moieties;
the chewing gum composition contains no more than 5% of the trans nicotine-N-oxide and no more than 3% of the cis nicotine-N-oxide when placed in a sealed plastic bottle and stored for four (4) weeks at 50° C. and 75% relative humidity; and
the chewing gum composition contains no more than 5% of the trans nicotine-N-oxide and no more than 2.5% of the cis nicotine-N-oxide when packaged in a foil backed blister package and stored for six months at 40° C. and 75% relative humidity.