Method of controlling diffusive sodium transport in dialysis
A method of controlling diffusive sodium transport from the dialysate solution to the blood of a patient undergoing hemodialysis treatment or from the blood to the dialysate solution includes calculating SNa + average , an average of the patient's historic serum sodium concentrations, and estimating SNa + estimated , the patient's pre-dialysis serum sodium concentration, based on the average of the patient's measured historic pre-dialysis serum sodium concentrations, SNa + measured . The method enables adjusting DNa + , the sodium concentration of the dialysate solution, based on the average of the patient's historic serum sodium concentrations, SNa + average , if needed, and performing the dialysis treatment of the patient using a dialysate solution containing a sodium concentration DNa + .
1. A method of controlling diffusive sodium transport from dialysate solution to blood of a patient undergoing hemodialysis treatment or from blood into the dialysate solution comprising:
a) calculating SNa + average , an average of the patient's measured historic serum sodium concentrations, SNa + measured ;
b) estimating SNa + estimated , the patient's pre-dialysis serum sodium concentration, based on the average, SNa + average , of the patient's pre-dialysis serum sodium concentrations over a historic time interval of at least 4 months;
c) determining GNa+, a desired gradient between SNa + estimated and DNa + , the sodium concentration in a dialysate solution; and
d) performing the dialysis treatment of the patient using the dialysate solution containing the sodium concentration DNa + based upon SNa + estimated .
2. The method of claim 1 , wherein the patient's historic serum sodium concentrations include corrections for void volume and Gibbs-Donnan effect.
3. The method of claim 1 , wherein DNa + =SNa + estimated .
4. The method of claim 2 , wherein DNa + =SNa + estimated .