Use of toll-like receptor-9 agonists
View Patent ↗The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic sepsis and necrotizing enterocolitis.
1. A method of treating necrotizing enterocolitis in a subject in need of such treatment comprising administering, to the subject, an effective amount of a TLR9 agonist oligonucleotide comprising one or more copy of 5′ GTCGTT 3′ (SEQ ID NO:11).
2. The method of claim 1 , where the oligonucleotide further comprises 5′ GACGTT 3′ (SEQ ID NO:18).
3. The method of claim 2 , where the oligonucleotide comprises 5′ TCGTCGTTTTGTCGTTCCTGACGTT 3′ (SEQ ID NO:10).
4. The method of claim 1 , where the oligonucleotide is orally administered.