2-amido pyrazines for inflammation and immune related uses

1. A compound represented by structural formula (V):

or a pharmaceutically acceptable salt thereof, wherein:

each Z is independently selected from the group consisting of a lower alkyl, a lower haloalkyl, a halo, a lower alkoxy, a lower alkyl sufanyl, cyano, nitro, or lower haloalkoxy;

R 12 is an aryl or a heteroaryl, wherein the aryl and heteroaryl are optionally substituted with one or more substituent selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteraralkyl, a halo, cyano, nitro, —OR 17 , —SR 17 , —S(O) p R 17 , —S(O) p OR 17 , —OS(O) p R 17 , —OS(O) p OR 17 , —NR 17 S(O) p R 17 , —S(O) p NR 15 R 16 , —NR 15 R 16 , —C(X 3 )R 17 , —C(X 3 )OR 17 , —C(X 3 )SR 17 , —C(X 3 )NR 15 R 16 , —NR 17 C(X 3 )R 18 , —NR 17 C(X 3 )OR 18 , —NR 17 C(X 3 )SR 18 , —NR 17 C(X 3 )NR 15 R 16 , —OC(X 3 )R 17 , —OC(X 3 )OR 17 , —OC(X 3 )SR 17 , —SC(X 3 )OR 17 , —SC(X 3 )SR 17 , —OC(X 3 )NR 15 R 16 , —SC(X 3 )NR 15 R 16 , —P(X 4 )(X 5 R 17 ) 2 , —X 5 P(X 4 )(X 5 R 17 ) 2 , —P(X 4 )(R 17 ) 2 , —P(X 4 )(R 17 )(X 5 R 17 );

R 13 is a cycloalkyl, a cycloalkenyl, an aryl, or a heteroaryl, wherein the cycloalkyl, cycloalkenyl, aryl, or heteroaryl are optionally substituted with one or more substituents selected from the group consisting of a lower alkyl, a halo, cyano, nitro, a lower haloalkyl, a lower alkoxy, a lower sulfanylalkyl, —S(O) p R 31 , —S(O) p NR 29 R 30 , —NR 29 R 30 , —C(O)R 28 , —C(O)OR 28 , —C(O)NR 29 R 30 , —NR 29 C(O)R 30 , —NR 29 C(O)OR 28 , —NR 28 C(O)NR 29 R 30 , —OC(O)R 28 , —OC(O)OR 28 , and —OC(O)NR 29 R 30 ; wherein R 28 , R 29 , R 30 , for each occurrence are, independently, H or a lower alkyl; and R 31 , for each occurrence, is independently a lower alkyl;

R 14 , for each occurrence is independently selected from —H, an alkyl, —C(O)R 20 , or —C(O)OR 20 ;

R 15 and R 16 , for each occurrence are, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl; or R 15 and R 16 taken together with the nitrogen to which they are attached are heterocyclyl or heteroaryl;

R 17 and R 18 , for each occurrence are, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl;

R 19 , for each occurrence, is independently —H, a halo, an alkyl, —OR 17 , —NR 15 R 16 , —C(O)R 17 , —C(O)OR 17 , or —C(O)NR 15 R 16 ;

R 20 , for each occurrence, is independently, H or an alkyl;

X 3 is ═O, ═S, or ═N—R 19 ;

X 4 is ═O or ═S;

X 5 is —O— or —S—;

n is 0, 1 or 2; and

p is 1 or 2.

2. The compound of claim 1 , wherein R 12 is selected from the group consisting of phenyl, naphthyl, anthracenyl, pyridyl, furyl, thienyl, pyrrolyl, oxazolyl, imidazolyl, indolizinyl, thiazolyl, isoxazolyl, pyrazolyl, isothiazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, triazolyl, thiadiazolyl, quinolinyl, isoquinolinyl, indazolyl, benzofuryl, imidazopyridinyl, tetrazolyl, benzoxazolyl, benzothiazolyl, benzothiadiazolyl, benzoxadiazolyl, indolyl, azaindolyl, quinazolinyl, purinyl, pyrrolo[2,3]pyrimidyl, pyridopyrimidyl, pyrazolo[3,4]pyrimidyl or benzo(b)thienyl.

3. The compound of claim 2 , wherein R 12 is phenyl, tetrazolyl, or pyridinyl.

4. The compound of claim 1 , wherein R 13 is aryl or heteroaryl.

5. The compound of claim 4 , wherein R 13 is phenyl or pyridinyl.

6. The compound of claim 5 , wherein the compound is represented by structural formula (III):

or a pharmaceutically acceptable salt thereof, wherein:

X 1 is CH, CR 4 , or N;

X 2 is CH, CR 3 , or N;

R 3 , for each occurrence is, independently, a halo, cyano, nitro, a lower alkyl, a lower haloalkyl, a lower alkoxy, a lower sulfanylalkyl, —NH 2 , a lower alkylamino, a lower dialkylamino, or —C(O)R a , where R a is H or lower alkyl;

R 4 , for each occurrence, is, independently, a halo, cyano, nitro, an alkyl, an alkoxy, alkylsulfanyl, hydroxyl, a heteroaryl, —NH 2 , alkylamino, dialkylamino, or —C(O)R 6 ;

R 6 , for each occurrence, is independently, H, an alkyl, a cycloalkyl, a heterocyclyl, an aryl, a heteroaryl, an aralkyl, or a heteraralkyl, —OR 7 , —SR 7 , or —NR 7 R 7 ;

R 7 , for each occurrence, is independently, H, an alkyl, a cycloalkyl, a heteroalkyl, a heterocyclyl, an aryl, a heteroaryl, an aralkyl, or a heteraralkyl; and

q and t, for each occurrence are, independently, 0 or an integer from 1 to 4.

7. The compound of claim 6 , wherein the compound is represented by structural formula (IV):

or a pharmaceutically acceptable salt thereof, wherein:

X 6 and X 7 are each, independently, CH or N;

R 8 and R 9 are each, independently, a halo, a lower alkyl, a lower alkoxy, or a lower haloalkoxyl; and

R 10 and R 11 , are each, independently, a halo, cyano, a lower alkyl, a lower alkoxy, a lower alkyl ester, —C(O)NH 2 , furanyl, oxazolyl, oxadiazolyl, or tetrazolyl.

8. The compound of claim 7 , wherein R 8 and R 9 are fluoro.

9. The compound selected from the group consisting of:

N-[5-(2-Chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-2,6-difluoro-benzamide;

N-[5-(2-Chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-3-fluoro-isonicotinamide;

N-[5-(2-Chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(2-Chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-2,6-difluoro-benzamide hydrochloride;

2,6-Difluoro-N-{5-[2-methyl-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-pyrazin-2-yl}-benzamide;

3-[5-(2,6-Difluoro-benzoylamino)-pyrazin-2-yl]-4-methyl-benzoic acid methyl ester;

4-Methyl-3-{5-[(3-methyl-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-benzoic acid methyl ester;

3-[5-(2,6-Difluoro-benzoylamino)-pyrazin-2-yl]-4-methyl-benzoic acid propyl ester;

3-[5-(2,6-Difluoro-benzoylamino)-pyrazin-2-yl]-4-methyl-benzoic acid 2-methoxy-ethyl ester;

4-Chloro-3-[5-(2,6-difluoro-benzoylamino)-pyrazin-2-yl]-benzoic acid methyl ester;

4-Chloro-3-[5-(2,6-difluoro-benzoylamino)-pyrazin-2-yl]-benzoic acid ethyl ester;

4-Chloro-3-[5-(2,6-difluoro-benzoylamino)-pyrazin-2-yl]-benzoic acid 2-methoxy-ethyl ester;

2,6-Difluoro-N-[5-(5-furan-2-yl-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-benzamide;

2,6-Difluoro-N-[5-(5-furan-3-yl-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-benzamide;

N-[5-(5-Chloro-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-2,6-difluoro-benzamide;

N-[5-(5-Bromo-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-2,6-difluoro-benzamide;

N-[5-(2-Ethyl-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-2,6-difluoro-benzamide;

3-[5-(2,6-Difluoro-benzoylamino)-pyrazin-2-yl]-4-methyl-benzamide;

4-[5-(2,6-Difluoro-benzoylamino)-pyrazin-2-yl]-3-methyl-benzoic acid methyl ester;

4-[5-(2,6-Difluoro-benzoylamino)-pyrazin-2-yl]-3-methyl-benzoic acid ethyl ester;

4-[5-(2,6-Difluoro-benzoylamino)-pyrazin-2-yl]-3-methyl-benzoic acid 2-methoxy-ethyl ester;

3-Chloro-4-[5-(2,6-difluoro-benzoylamino)-pyrazin-2-yl]-benzoic acid methyl ester;

3-Chloro-4-[5-(2,6-difluoro-benzoylamino)-pyrazin-2-yl]-benzoic acid ethyl ester;

3-Chloro-4-[5-(2,6-difluoro-benzoylamino)-pyrazin-2-yl]-benzoic acid 2-methoxy-ethyl ester;

3-Fluoro-N-[5-(5-furan-2-yl-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-isonicotinamide;

3-Fluoro-N-[5-(5-furan-3-yl-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-isonicotinamide;

N-[5-(5-Chloro-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-3-fluoro-isonicotinamide;

N-[5-(5-Bromo-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-3-fluoro-isonicotinamide;

3-Fluoro-N-[5-(2-methyl-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-isonicotinamide;

N-[5-(5-Carbamoyl-2-methyl-phenyl)-pyrazin-2-yl]-3-fluoro-isonicotinamide;

N-[5-(5-Cyano-2-methyl-phenyl)-pyrazin-2-yl]-3-fluoro-isonicotinamide;

3-{5-[(3,5-Difluoro-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-4-methyl-benzoic acid methyl ester;

3-{5-[(3,5-Difluoro-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-4-methyl-benzoic acid ethyl ester;

3-{5-[(3,5-Difluoro-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-4-methyl-benzoic acid 2-methoxy-ethyl ester;

4-Chloro-3-{5-[(3,5-difluoro-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-benzoic acid methyl ester;

4-Chloro-3-{5-[(3,5-difluoro-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-benzoic acid ethyl ester;

4-Chloro-3-{5-[(3,5-difluoro-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-benzoic acid 2-methoxy-ethyl ester;

3,5-Difluoro-N-[5-(5-furan-2-yl-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-isonicotinamide;

3,5-Difluoro-N-[5-(5-furan-3-yl-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-isonicotinamide;

N-[5-(5-Chloro-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-3,5-difluoro-isonicotinamide;

N-[5-(5-Bromo-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-3,5-difluoro-isonicotinamide;

N-[5-(2-Ethyl-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-3,5-difluoro-isonicotinamide;

N-[5-(5-Carbamoyl-2-methyl-phenyl)-pyrazin-2-yl]-3,5-difluoro-isonicotinamide;

3,5-Difluoro-N-[5-(5-cyano-2-methyl-phenyl)-pyrazin-2-yl]-isonicotinamide;

4-Methyl-3-{5-[(3-methyl-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-benzoic acid ethyl ester;

4-Methyl-3-{5-[(3-methyl-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-benzoic acid 2-methoxy-ethyl ester;

4-Chloro-3-{5-[(3-methyl-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-benzoic acid methyl ester;

4-Chloro-3-{5-[(3-methyl-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-benzoic acid ethyl ester;

4-Chloro-3-{5-[(3-methyl-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-benzoic acid 2-methoxy-ethyl ester;

N-[5-(2-Chloro-5-furan-2-yl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(2-Chloro-5-furan-3-yl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(5-Chloro-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(5-Bromo-2-methoxy-pyridin-3-yl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(2-Ethyl-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(5-Carbamoyl-2-methyl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(5-Cyano-2-methyl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

2,6-Difluoro-N-[5-(2-methyl-5-oxazol-2-yl-phenyl)-pyrazin-2-yl]-benzamide;

2,6-Difluoro-N-{5-[2-methyl-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-phenyl]-pyrazin-2-yl}-benzamide;

2,6-Difluoro-N-{5-[2-methyl-5-(1H-tetrazol-5-yl)-phenyl]-pyrazin-2-yl}-benzamide;

3-Fluoro-N-[5-(2-methyl-5-oxazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3-Methyl-N-[5-(2-methyl-5-oxazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3,5-Difluoro-N-[5-(2-methyl-5-oxazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2-methyl-5-oxazol-2-yl-phenyl)-pyrazin-2-yl]-amide;

3-Fluoro-N-[5-(2-methyl-5-thiazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3-Methyl-N-[5-(2-methyl-5-thiazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3,5-Difluoro-N-[5-(2-methyl-5-thiazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2-methyl-5-thiazol-2-yl-phenyl)-pyrazin-2-yl]-amide;

N-[5-(2-Chloro-5-oxazol-2-yl-phenyl)-pyrazin-2-yl]-3-fluoro-isonicotinamide;

N-[5-(2-Chloro-5-oxazol-2-yl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(2-Chloro-5-oxazol-2-yl-phenyl)-pyrazin-2-yl]-3,5-difluoro-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2-chloro-5-oxazol-2-yl-phenyl)-pyrazin-2-yl]-amide;

3-Fluoro-N-[5-(2-methyl-5-[1,3,4]oxadiazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3-Methyl-N-[5-(2-methyl-5-[1,3,4]oxadiazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3,5-Difluoro-N-[5-(2-methyl-5-[1,3,4]oxadiazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2-methyl-5-[1,3,4]oxadiazol-2-yl-phenyl)-pyrazin-2-yl]-amide;

3-Fluoro-N-[5-(2-methyl-5-[1,3,4]thiadiazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3-Methyl-N-[5-(2-methyl-5-[1,3,4]thiadiazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3,5-Difluoro-N-[5-(2-methyl-5-[1,3,4]thiadiazol-2-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2-methyl-5-[1,3,4]thiadiazol-2-yl-phenyl)-pyrazin-2-yl]-amide;

N-[5-(2-Chloro-5-[1,3,4]oxadiazol-2-yl-phenyl)-pyrazin-2-yl]-3-fluoro-isonicotinamide;

N-[5-(2-Chloro-5-[1,3,4]oxadiazol-2-yl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(2-Chloro-5-[1,3,4]oxadiazol-2-yl-phenyl)-pyrazin-2-yl]-3,5-difluoro-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2-chloro-5-[1,3,4]oxadiazol-2-yl-phenyl)-pyrazin-2-yl]-amide;

3-Fluoro-N-[5-(2-methyl-5-oxazol-5-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3-Methyl-N-[5-(2-methyl-5-oxazol-5-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3,5-Difluoro-N-[5-(2-methyl-5-oxazol-5-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2-methyl-5-oxazol-5-yl-phenyl)-pyrazin-2-yl]-amide;

3-Fluoro-N-[5-(2-methyl-5-thiazol-5-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3-Methyl-N-[5-(2-methyl-5-thiazol-5-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

3,5-Difluoro-N-[5-(2-methyl-5-thiazol-5-yl-phenyl)-pyrazin-2-yl]-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2-methyl-5-thiazol-5-yl-phenyl)-pyrazin-2-yl]-amide;

N-[5-(2-Chloro-5-oxazol-5-yl-phenyl)-pyrazin-2-yl]-3-fluoro-isonicotinamide;

N-[5-(2-Chloro-5-oxazol-5-yl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(2-Chloro-5-oxazol-5-yl-phenyl)-pyrazin-2-yl]-3,5-difluoro-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2-chloro-5-oxazol-5-yl-phenyl)-pyrazin-2-yl]-amide;

3-Fluoro-N-[5-(5-isoxazol-5-yl-2-methyl-phenyl)-pyrazin-2-yl]-isonicotinamide;

N-[5-(5-Isoxazol-5-yl-2-methyl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

3,5-Difluoro-N-[5-(5-isoxazol-5-yl-2-methyl-phenyl)-pyrazin-2-yl]-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(5-isoxazol-5-yl-2-methyl -phenyl)-pyrazin-2-yl]-amide;

3-Fluoro-N-[5-(5-isothiazol-5-yl-2-methyl-phenyl)-pyrazin-2-yl]-isonicotinamide;

N-[5-(5-Isothiazol-5-yl-2-methyl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

3,5-Difluoro-N-[5-(5-isothiazol-5-yl-2-methyl-phenyl)-pyrazin-2-yl]-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(5-isothiazol-5-yl-2-methyl -phenyl)-pyrazin-2-yl]-amide;

N-[5-(2-Chloro-5-isoxazol-5-yl-phenyl)-pyrazin-2-yl]-3-fluoro-isonicotinamide;

N-[5-(2-Chloro-5-isoxazol-5-yl-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(2-Chloro-5-isoxazol-5-yl-phenyl)-pyrazin-2-yl]-3,5-difluoro-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2-chloro-5-isoxazol-5-yl-phenyl)-pyrazin-2-yl]-amide;

3-{5-[(3-Fluoro-pyridine-4-carbonyl)-amino]-pyrazin-2-yl}-4-methyl-benzoic acid methyl ester;

N-[5-(2,5-Dimethoxy-phenyl)-pyrazin-2-yl]-2,6-difluoro-benzamide;

N-[5-(2-Chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-2-methyl-nicotinamide;

Cyclohexanecarboxylic acid [5-(2-chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide;

N-[5-(2,5-Dimethoxy-phenyl)-pyrazin-2-yl]-3-fluoro-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2-chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide;

N-[5-(2-Chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-3,5-difluoro-isonicotinamide;

N-[5-(2,5-Dimethoxy-phenyl)-pyrazin-2-yl]-3-methyl-isonicotinamide;

N-[5-(2,5-Dimethoxy-phenyl)-pyrazin-2-yl]-3,5-difluoro-isonicotinamide;

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid [5-(2,5-dimethoxy-phenyl)-pyrazin-2-yl]-amide;

Cyclohexanecarboxylic acid [5-(2,5-dimethoxy-phenyl)-pyrazin-2-yl]-amide;

Cyclohexanecarboxylic acid [5-(2-methyl-5-oxazol-2-yl-phenyl)-pyrazin-2-yl]-amide;

or a pharmaceutically acceptable salt thereof.

10. A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and a compound of claim 1 , 6 , 7 or 9 .

11. The pharmaceutical composition of claim 10 , further comprising one or more additional therapeutic agents.

12. The pharmaceutical composition according to claim 11 , wherein the additional therapeutic agent is selected from the group consisting of immunosuppressive agents, anti-inflammatory agents and suitable mixtures thereof.

13. The pharmaceutical composition of claim 12 , wherein the additional therapeutic agent is selected from the group consisting of steroids, non-steroidal anti-inflammatory agents, antihistamines, analgesics, and suitable mixtures thereof.