Blood processing filter
A flexible blood filter allowing smooth flow of a liquid and being excellent in separation resistance, pressure resistance and centrifugation resistance. The blood processing filter, comprising a first filter element for removing aggregates from blood, a second filter element for removing leukocytes provided in the downstream of the first filter element, and the third filter element having gas permeability of 3 to 40 cc/cm 2 /sec per thickness of 1 cm provided between the second filter element and the outlet port side container.
1. A blood processing filter for removing undesirable components from blood, comprising;
a flexible container, which has a blood inlet port and a blood outlet port; and
a sheet-like filter element inside the flexible container for removing undesirable components from blood passing through the container, wherein the blood inlet port is separated from the blood outlet port by the sheet-like filter element,
the sheet-like filter element comprising,
a first filter element for removing aggregate from blood,
a second filter element downstream of the first filter element to remove leukocytes, and
a third filter element downstream of the second filter element adjacent to the blood outlet port and that allows passage of blood constituents,
wherein said third filter element has having a Gas permeability per 1 cm thickness of 3-40 cc/cm2/sec and a thickness of 0.04-0.25 cm, and wherein said third filter element has a Gas permeability per 1 cm thickness which increases away from said second filter element towards said blood outlet port.
2. The blood processing filter according to claim 1 , having a seal zone formed by integrating a section near the periphery of the sheet-like filter element with the flexible container over its entire circumference.
3. The blood processing filter according to claim 1 , having a first seal zone formed by integrating a section near the periphery of the sheet-like filter element with the flexible container over its entire circumference, a second seal zone formed by integrating the inlet side flexible container with the outlet side flexible container over the entire outside circumference of the first seal zone, and an unsealed zone disposed between the first seal zone and the second seal zone.
4. The blood processing filter according to claim 1 , further comprising at least one flexible sheet-like frame disposed between the flexible container and the sheet-like filter element,
wherein the blood inlet port is separated from the outlet port by the filter element and the at least one flexible sheet-like frame.
5. The blood processing filter according to claim 4 , having the first seal zone formed by joining the entire circumference of the section near the periphery of the sheet-like filter element with at least one sheet-like frame, and the second seal zone formed by integrating the inlet side flexible container with at least one sheet-like frame and the outlet side flexible container over the entire outside circumference of the first seal zone.
6. The blood processing-filter according to claim 4 , wherein the inlet port and outlet port are provided between the inlet port side flexible container or the outlet port side flexible container and the sheet-like frame, and also, each of the inlet port and outlet port communicatingly connected the inside with outside of the container, while being liquid-tightly joined with the second seal zone.
7. The blood processing filter according to claim 1 , wherein the flexible container is formed from a sheet-like formed material.
8. The blood processing filter according to claim 1 , wherein the flexible container is formed from a cylindrical formed material.
9. The blood processing filter according to claim 1 , wherein the inlet port and outlet port made from formed parts are liquid-tightly joined with the flexible container.
10. The blood processing filter according to claim 1 , wherein the flexible container is formed from soft polyvinyl chloride.
11. The blood processing filter according to claim 1 , wherein the inlet port and outlet port are formed from soft polyvinyl chloride.
12. The blood processing filter according to claim 1 , wherein the flexible container is formed from polyolefin.
13. The blood processing filter according to claim 12 , wherein the inlet port and outlet port are formed from polyolefin.
14. A method of filtering blood or a blood preparation, comprising:
allowing the blood or blood preparation to pass through a filter by action of gravity, wherein the filter includes a flexible container that has a blood inlet port and a blood outlet port, and a sheet-like filter element inside the flexible container removing undesirable components from blood passing through the container, the blood inlet port being separated from the blood outlet port by the sheet-like filter element, the sheet-like filter element comprising a first filter element for removing aggregate from blood, a second filter element downstream of the first filter element to remove leukocytes, and a third filter element downstream of the second filter element adjacent to the blood outlet port and that allows passage of blood constituents, the third filter element having a Gas permeability per 1 cm thickness of 3-40 cc/cm2/sec and a thickness of 0.04-0.25 cm and having a Gas permeability per 1 cm thickness which increases away from said second filter element towards said blood outlet port; and
creating a negative pressure at the blood outlet port of the filter.