Dosage regimen for COMT inhibitors
The invention relates to the use of an oxodiazolyl compound (I) for the preparation of a medicament for the prevention or treatment of central and peripheral nervous system associated disorders, wherein said medicament is administered according to a dosing regimen having a dosing periodicity ranging from about twice a day to about once every other day.
1. Method of treating a movement disorder in a patient in need thereof comprising administering to the patient about twice every day to about once every other day a pharmacologically effective dose of 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-3-nitrobenzene-1,2-diol or a pharmacologically acceptable salt thereof,
wherein the movement disorder is selected from Parkinson's disease, dystonia, dyskinesia, and extrapyrimidal syndromes.
2. Method as claimed in claim 1 wherein the administration is once daily.
3. Method as claimed in claim 1 wherein the administration is twice daily.
4. Method as claimed in claim 1 wherein the administration is once every other day.
5. Method according to claim 1 , wherein the movement disorder is treatable by L-DOPA and/or AADC therapy.
6. Method as claimed in claim 1 wherein the movement disorder is Parkinson's disease.
7. Method according to claim 1 wherein the method further comprises the step of administering L-DOPA to the patient.
8. Method according to claim 1 wherein the method further comprises the step of administering an AADC inhibitor to the patient.
9. Method according to claim 1 wherein the patient is receiving therapy with L-DOPA or an AADC inhibitor or both L-DOPA and an AADC inhibitor.
10. Method according to claim 1 wherein the method further comprises the step of administering of L-DOPA and an AADC inhibitor to the patient either concomitantly or sequentially with the compound as defined in claim 1 .
11. Method according to claim 1 wherein the method further comprises the step of administering of L-DOPA and an AADC inhibitor to the patient separately with the compound as defined in claim 1 .
12. Method according to claim 1 wherein the effective daily doses of compounds of formula I are in the range of 1 to 1000 mg/day.
13. Method according to claim 1 wherein the effective daily doses of compounds of formula I are in the range of 2 to 500 mg/day.
14. Method according to claim 1 wherein the effective daily doses of compounds of formula I are in the range of 3 to 250 mg/day.
15. Method according to claim 1 wherein the effective daily doses of compounds of formula I are in the range of 5 to 100 mg/day.
16. Method according to claim 1 wherein the administration is in the morning, mid-day, noon, afternoon, evening, or midnight.
17. Method according to claim 1 wherein the administration is in the evening.