Deuterium-enriched bupropion
The present application describes deuterium-enriched bupropion, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
1. A deuterium-enriched compound of formula I or a pharmaceutically acceptable salt thereof:
wherein R 1 and R 3 -R 18 are independently selected from H and D.
2. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.
3. A method for treating a disease selected from depression and smoking, comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.
4. A compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
5. A compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
6. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 4 or a pharmaceutically acceptable salt form thereof.
7. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 5 or a pharmaceutically acceptable salt form thereof.
8. A method for treating a disease selected from depression and smoking, comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 4 or a pharmaceutically acceptable salt form thereof.
9. A method for treating a disease selected from depression and smoking, comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 5 or a pharmaceutically acceptable salt form thereof.