Methods for micronization of hydrophobic drugs
The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use.
1. A method for micronizing a hydrophobic agent, comprising:
(i) dissolving the hydrophobic agent in an effective amount of a first solvent, with a polymer, wherein the hydrophobic agent and the first solvent form a mixture having a continuous phase,
(ii) introducing a second solvent into the mixture, and
(iii) introducing water into the mixture, wherein the water causes precipitation of the hydrophobic agent to produce a composition of micronized particles of hydrophobic agent having an average particle size of 1 micron or less, wherein the composition is free of surfactant.
2. The method of claim 1 , wherein the micronized particles contain less than 5% polymer.
3. The method of claim 1 , wherein the polymer is removed by the water,
4. The method of claim 1 , further comprising the step of encapsulating the micronized particles of hydrophobic agent in polymeric microparticles by a method selected from the group consisting of: spray drying, interfacial polymerization, hot melt encapsulation, phase separation encapsulation, phase inversion nanoencapsulation, spontaneous emulsion, solvent evaporation microencapsulation, solvent removal microencapsulation, coacervation, and low temperature microsphere formation.
5. The method of claim 1 , further comprising the step of encapsulating the micronized particles of hydrophobic agent in polymeric microparticles by a method selected from the group consisting of solvent evaporation, hot melt encapsulation, and phase separation encapsulation.
6. The method of claim 1 , further comprising the step of encapsulating the micronized particles of hydrophobic agent in polymeric microparticles by performing phase inversion nanoencapsulation on the micronized particles of hydrophobic agent.
7. The method of claim 1 , wherein the second solvent is an alcohol.
8. The method of claim 7 , wherein the alcohol is selected from the group consisting of: methanol (methyl alcohol), ethanol, (ethyl alcohol), 1-propanol (n-propyl alcohol), 2-propanol (isopropyl alcohol), 1-butanol (n-butyl alcohol), 2-butanol (sec-butyl alcohol), 2-methyl-1-propanol (isobutyl alcohol), 2-methyl-2-propanol (t-butyl alcohol), 1-5pentanol (n-pentyl alcohol), 3-methyl-1-butanol (isopentyl alcohol), 2,2-dimethyl-1-propanol (neopentyl alcohol), cyclopentanol (cyclopentyl alcohol), 1-hexanol (n-hexanol), cyclohexanol (cyclohexyl alcohol), 1-heptanol (n-heptyl alcohol), 1-octanol (n-octyl alcohol), 1-nonanol (n-nonyl alcohol), 1-decanol (n-decyl alcohol), 2-propen-1-ol (allyl alcohol), phenylmethanol (benzyl alcohol), diphenylmethanol (diphenylcarbinol), triphenylmethanol (triphenyicarbinol), glycerin, phenol, 2-methoxyethanol, 2-ethoxyethanol, 3-ethoxy-1,2-propanediol, di(ethylene glycol) methyl ether, 12-propanediol, 1,3-propanediol, 1,3-butanediol, 2,3-butanediol, 18-butanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 2,5-pentanediol, 3,4-pentanediol, and 3,5-pentanediol.
9. The method of claim 7 , wherein the alcohol is isopropanol.
10. The method of claim 1 , wherein the second solvent is a mixture of alcohols.
11. The method of claim 10 , wherein the mixture of alcohols comprises: two or more of the alcohols selected from the group consisting of: methanol (methyl alcohol), ethanol, (ethyl alcohol), 1-propanol (n-propyl alcohol), 2-propanol (isopropyl alcohol), 1-butanol (n-butyl alcohol), 2-butanol (sec-butyl alcohol), 2-methyl-1-propanol (isobutyl alcohol), 2-methyl-2-propanol (t-butyl alcohol), 1-pentanol (n-pentyl alcohol), 3-methyl-1-butanol (isopentyl alcohol), 2,2-dimethyl-1-propanol (neopentyl alcohol), cyclopentanol (cyclopentyl alcohol), 1-hexanol (n-hexanol), cyclohexanol (cyclohexyl alcohol), 1-heptanol (n-heptyl alcohol), 1-octanol (n-octyl alcohol), 1-nonanol (n-nonyl alcohol), 1-decanol (n-decyl alcohol), 2-propen-1-ol (allyl alcohol), phenylmethanol (benzyl alcohol), diphenylmethanol (diphenylcarbinol), triphenylmethanol (triphenylcarbinol), lycerin, phenol, 2-methoxyethanol, 2-ethoxyethanol, 3-ethoxy-1,2-propanediol, di(ethylene glycol) methyl ether, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 2,5-pentanediol, 3,4-pentanediol, and 3,5-pentanediol.
12. The method of claim 1 , wherein greater than 90% of the micronized hydrophobic agent have a particle size less than 1 micron.
13. The method of claim 1 , wherein the hydrophobic agent is dissolved by:
(a) heating the hydrophobic agent in the first solvent;
(b) sonicating the hydrophobic agent in the first solvent;
(c) shearing the hydrophobic agent in the first solvent; or
(d) stirring the hydrophobic agent in the first solvent.