IP Library › Granted Patent US 8,541,369
Granted Patent B2
US 8,541,369 · App. 13/626,308 · Granted Sep 24, 2013

Fibroblast growth factor 21 variants having improved pharmacological potency and/or improved pharmaceutical stability

Inventors: Craig Duane Dickinson (San Diego, CA); David Albert Driver (Solana Beach, CA); Ryan James Darling (Fishers, IN); Maigorzata Donata Gonciarz (Indianapolis, IN); Radmila Micanovic (Indianapolis, IN)
Assignee: Eli Lilly and Company
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Quick Facts
Patent No.
US 8,541,369
App. No.
13/626,308
Granted
Sep 24, 2013
Kind
B2
Abstract

This present invention relates to pharmacologically potent and/or stable variants of human fibroblast growth factor 21 (FGF21), pharmaceutical compositions comprising FGF21 variants, and methods for treating type 2 diabetes, obesity, dyslipidemia, or metabolic syndrome, or any combination thereof, using such variants.

Claims (8)

1. A variant of human fibroblast growth factor 21 (FGF21), wherein the amino acid sequence is

(SEQ ID NO: 1)

HPIPDSSPLLQFGGQVRQRYLYTDDAQQTECHLEIREDGTVGCAADQSPE

SLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFREDLL

EDGYNVYQSEAHGLPLHLPGDKSPHRKPAPRGPARFLPLPGLPPALPEPP

GILAPQPPDVGSSDPLRLVEPSQLLSPSFLG.

2. A pharmaceutical composition comprising the variant of claim 1 , and at least one pharmaceutically acceptable carrier, diluent, or excipient.

3. A method for treating type 2 diabetes, obesity, dyslipidemia, or metabolic syndrome, or any combination thereof, comprising administering the variant of claim 1 to a patient in need thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 25, 2012
From: DICKINSON, CRAIG DUANE; DRIVER, DAVID ALBERT; DARLING, RYAN JAMES; GONCIARZ, MALGORZATA DONATA; MICANOVIC, RADMILA
To: ELI LILLY AND COMPANY
Reel/Frame 029035/0989 →
Continuity (2)
Provisional Application 61542906 · Oct 4, 2011
Related Publication 20130085098A1 · Apr 4, 2013