IP Library Granted Patent US 8,541,572
Granted Patent B2
US 8,541,572 · App. 13/127,952 · Granted Sep 24, 2013

Compounds for the treatment of inflammatory disorders

Inventors: Joseph A. Kozlowski (Princeton, NJ); Wensheng Yu (Edison, NJ); Michael K. C. Wong (Somerset, NJ); Seong Heon Kim (Livington, NJ); Ling Tong (Warren, NJ); Brian J. Lavey (New Providence, NJ); Bandarpalle B. Shankar (Branchburg, NJ); De-Yi Yang (Morris Plains, NJ); Robert Feltz (Washington, PA); Aneta Maria Kosinski (South Amboy, NJ); Guowei Zhou (Somerset, NJ); Razia K. Rizvi (Bloomfield, NJ); Chaoyang Dai (Acton, MA); Luke Fire (Cambridge, MA); Vinay Girijavallabhan (Denville, NJ); Dansu Li (Reading, MA); Janeta Popovici-Muller (Waltham, MA); Judson E. Richard (Kittery, ME); Kristin E. Rosner (Watertown, MA); M. Arshad Siddiqui (Newton, MA); Liping Yang (Arlington, MA)
Assignee: Merck Sharp & Dohme Corp.
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Quick Facts
Patent No.
US 8,541,572
App. No.
13/127,952
Granted
Sep 24, 2013
Kind
B2
Abstract

This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.

Claims (7)

1. A compound selected from the group consisting of

and a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , selected from the group consisting of:

and a pharmaceutically acceptable salt thereof.

3. The compound of claim 2 , selected from the group consisting of:

and a pharmaceutically acceptable salt thereof.

4. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.

Assignments (3)
MERGER Recorded Oct 19, 2012
From: SCHERING CORPORATION
To: MERCK SHARP & DOHME CORP.
Reel/Frame 029160/0642 →
CHANGE OF NAME Recorded Oct 16, 2012
From: SCHERING CORPORATION
To: MERCK SHARP & DOHME CORP.
Reel/Frame 029140/0204 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 12, 2012
From: KOZLOWSKI, JOSEPH A.; YU, WENSHENG; WONG, MICHAEL C.; KIM, SEONG HEON; TONG, LING; LAVEY, BRIAN J.; SHANKAR, BANDARPALLE B.; YANG, DE-YI; KOSINSKI, ANETA MARIA; ZHOU, GUOWEI; RIZVI, RAZIA K.; GIRIJAVALLABHAN, VINAY M.; FELTZ, ROBERT; DAI, CHAOYANG; FIRE, LUKE; LI, DANSU; POPOVICI-MULLER, JANETA; RICHARD, JUDSON E.; ROSNER, KRISTEN E.; SIDDIQUI, M. ARSHAD; YANG, LIPING
To: SCHERING CORPORATION
Reel/Frame 029119/0128 →
Continuity (2)
Provisional Application 61113071 · Nov 10, 2008
Related Publication 20120010181A1 · Jan 12, 2012