Analogs of tetramic acid
Tetramic acid analogues of Formula I and Formula II have antibacterial activity, primarily against gram-positive bacteria, and are iron chelators.
1. A chemical compound selected from the group consisting of (S,Z)-1-benzyl-5-sec-butyl-3-(1-hydroxyethylidene)pyrrolidine-2,4-dione, (S,Z)-1-decyl-3-(1-hydroxyethylidene)-5-isobutylpyrrolidine-2,4-dione, (S,Z)-1,5-dibenzyl-3-(1-hydroxyethylidene)pyrrolidine-2,4-dione, (S,Z)-3-(1-hydroxyethylidene)-5-isobutyl-1-(3-methoxybenzyl)pyrrolidine-2,4-dione, (S,Z)-1-(4-fluorobenzyl)-3-(1-hydroxyethylidene)-5-isobutylpyrrolidine-2,4-dione, (R,Z)-1-(4-fluorobenzyl)-3-(1-hydroxyethylidene)-5-isobutylpyrrolidine-2,4-dione, (R,Z)-1,5-dibenzyl-3-(1-hydroxyethylidene)pyrrolidine-2,4-dione, (S,Z)-5-benzyl-1-ethyl-3-(1-hydroxyethylidene)pyrrolidine-2,4-dione, (S,Z)-1-decyl-3-(1-hydroxyethylidene)-5-isopropylpyrrolidine-2,4-dione, (S,Z)-1-butyl-3-(1-hydroxyethylidene)-5-isobutylpyrrolidine-2,4-dione, (S,Z)-1-(biphenyl-4-ylmethyl)-3-(1-hydroxyethyl idene)-5-isobutylpyrrolidine-2,4-dione, (5S,Z)-1-((6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)-3-(1-hydroxyethylidene)-5-isobutyl pyrrolidine-2,4-dione, (5S,Z)-1-(3,7-dimethyloct-6-enyl)-3-(1-hydroxyethylidene)-5-isobutylpyrrolidine-2,4-dione, (S,Z)-5-benzyl-1-decyl-3-(1-hydroxyethylidene)pyrrolidine-2,4-dione, and (R,Z)-1-decyl-3-(1-hydroxyethylidene)-5-isobutylpyrrolidine-2,4-dione.
2. The chemical compound of claim 1 which is (S,Z)-1-decyl-3-(1-hydroxyethylidene)-5-isobutylpyrrolidine-2,4-dione.