Sterilizable indwelling catheters

1. An indwelling catheter comprising a catheter shaft and a hub from which said catheter shaft projects, wherein said hub comprises a light source or wherein said hub is adapted to receive light from a light source, said hub further comprising a port that is adapted to allow fluids to be delivered to patient, from the patient, or both, wherein said indwelling catheter is configured such that light is transmitted from said light source into said catheter shaft, and wherein said catheter shaft is formed of a polymeric material that transmits a quantity of said light from said light source that is effective to inactivate microorganisms on a surface of said catheter shaft when said light source is activated.

2. The indwelling catheter of claim 1 , wherein said light is selected from infrared, visible and ultraviolet light.

3. The indwelling catheter of claim 1 , wherein said light has a wavelength between 100 and 400 nm.

4. The indwelling catheter of claim 1 , wherein said medical device further comprises a photosensitizer.

5. The indwelling catheter of claim 4 , wherein said photosensitizer is provided in a coating on said catheter shaft.

6. The indwelling catheter of claim 4 , wherein said photosensitizer is a dye.

7. The indwelling catheter of claim 4 , wherein said photosensitizer is selected from thiazine dyes, acridine dyes, coumarin dyes, xanthene dyes, phenoxaziniums, phenazines, aromatic carbonyl compounds, condensed aromatic compounds, fluorene derivatives, psoralens, naphthalocyanines, porphyrin, thioketones and combinations thereof.

8. The indwelling catheter of claim 4 , wherein said photosensitizer is a phenothiazine dye.

9. The indwelling catheter of claim 4 , wherein said medical device comprises two or more photosensitizers.

10. The indwelling catheter of claim 1 , wherein said catheter shaft comprises a thermoplastic or a thermoset polymer.

11. The indwelling catheter of claim 1 , wherein said catheter shaft comprises a polymer selected from polycarbonates, acrylic polymers, polystyrenes, polyethylene terephthalates, polyamides, polyurethanes, polyether block amides, fluoropolymers, and combinations thereof.

12. The indwelling catheter of claim 1 , wherein said catheter shaft comprises a polyether-based thermoplastic polyurethane.

13. The indwelling catheter of claim 1 , wherein said hub is adapted to receive a light emitting component.

14. The indwelling catheter of claim 13 , wherein said light emitting component is said light source.

15. The indwelling catheter of claim 14 , wherein said light source is selected from a laser, a laser array, a light emitting diode, and a light emitting diode array.

16. The indwelling catheter of claim 13 , wherein said light emitting component is a light guide.

17. The indwelling catheter of claim 13 , wherein said hub comprises an optical coupling for optically coupling said light emitting component to said catheter.

18. The indwelling catheter of claim 1 , wherein said light source is integrated into said hub.

19. The indwelling catheter of claim 1 , selected from peripheral venous catheters and central venous access catheters.

20. The indwelling catheter of claim 1 , selected from peripherally inserted central catheters, midline catheters, peripheral catheters, hemodialysis catheters and venous access ports.

21. A kit comprising the indwelling catheter of claim 1 and a photosensitizer.

22. A kit comprising the indwelling catheter of claim 1 and a light emitting component selected from a light source, a light guide, or both.

23. A method of sterilizing the catheter of claim 1 , comprising activating said light source while said catheter is inserted in a subject.

24. The method of claim 23 , further comprising introducing a photosensitizer to said patient prior to or concurrent with activating said light source.

25. The method of claim 24 , wherein said photosensitizer is introduced locally.

26. The method of claim 24 , wherein said photosensitizer is introduced through said catheter.

27. The method of claim 24 , wherein said photosensitizer is introduced systemically.

28. The indwelling catheter of claim 1 , wherein said port comprises a connector selected from a threaded, luer, subminiature, press fit, and bayonet type connector.

29. The indwelling catheter of claim 18 , wherein said light source is selected from a laser, a laser array, a light emitting diode, and a light emitting diode array.

30. The indwelling catheter of claim 1 , wherein said catheter does not comprise an optical fiber light guide.

31. An indwelling catheter comprising (a) a catheter shaft and (b) a hub from which said catheter shaft projects, wherein said hub comprises (i) a port that is adapted to allow fluids to be delivered to the patient, from the patient, or both, and (ii) an optical coupling for optically coupling light from a light emitting component into said catheter shaft, wherein said light emitting component is adapted to emit light having a wavelength between 100 and 280 nm, wherein said catheter shaft is formed of a polymeric material that transmits a quantity of said light having a wavelength between 100 and 280 nm that is effective to inactivate microorganisms on a surface of said catheter shaft when said light emitting component is activated, and wherein said indwelling catheter is selected from a peripherally inserted central catheter, a midline catheter, a peripheral catheter, a hemodialysis catheter and a venous access port.