IP Library › Granted Patent US 8,557,803
Granted Patent B2
US 8,557,803 · App. 13/833,520 · Granted Oct 15, 2013

Purinone derivative

Inventors: Shingo Yamamoto (Osaka, JP); Toshio Yoshizawa (Osaka, JP)
Assignee: Ono Pharmaceutical Co., Ltd.
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Quick Facts
Patent No.
US 8,557,803
App. No.
13/833,520
Granted
Oct 15, 2013
Kind
B2
Abstract

Compounds represented by general formula (I) (all of the symbols in the formula conform to the definitions in the Description) are compounds that, in addition to having a Btk-selective inhibitory activity, exhibit an excellent metabolic stability and can avoid hepatotoxicity or the like, and as a consequence can provide safe therapeutic agents for diseases in which B cells or mast cells participate.

Claims (2)

1. 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one, or a salt thereof.

2. 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one.

Priority Claims (1)
JP 2010-123727 · May 31, 2010 · national
Continuity (2)
Continuation 13700774
Related Publication 20130217880A1 · Aug 22, 2013