Peptide for augmenting and expression of BDNF and pharmaceutical composition for prevention and treatment of neurodegenerative diseases including Alzheimer's disease or Parkinson's disease, comprising the same
Disclosed are peptides for augmenting the expression of BDNF (brain-derived neurotrophic factor) and a pharmaceutical composition for the prevention and treatment of Alzheimer's disease or Parkinson's disease, comprising the same. The peptides can induce the expression of BDNF in dopamine-reactive human cells, pass easily through the blood-brain barrier thanks to their low molecular weights and are almost free of cytotoxicity. Thus, they are useful in the prevention and treatment of neuropathies such as Alzheimer's disease or Parkinson's disease.
1. An isolated peptide for augmenting expression of BDNF (Brain-derived neurotrophic factor), having the following amino acid sequence: N′-(Z 1 ) α -Z 2 -(Z 3 ) β -C′ wherein, N′ is an N-terminus of the peptide and C′ is a C-terminus of the peptide;
Z 1 is G, M or R;
Z 2 is D, T or V;
Z 3 is F, G or Q;
α is 0 or 1; and β is 0 or 1, with a proviso that the peptide includes at least one of Z 1 =M, Z 2 =V and Z 3 =G, both α and β are not 0, and the peptide is not M-V-Q, V-G, M-V and M-T.
2. The peptide according to claim 1 , having an amino acid sequence selected from a group consisting of G-V-G, R-V-G, M-D-G, M-T-G, M-V-F, and M-V-G.
3. The peptide according to claim 1 , wherein the terminus N′ or C′ is acetylated or amidated.
4. The peptide according to claim 1 , wherein the peptide augments the expression of BDNF in dopamine-reactive, human cells.
5. A pharmaceutical composition for treating neuropathy, comprising the peptide of claim 1 in a therapeutically effective amount, the neuropathy being selected from a group consisting of Alzheimer's disease, Parkinson's disease, chronic stress-related mood disorder, stroke, Huntington's disease, schizophrenia, obsessive compulsive disorder, Rett syndrome, dementia, anorexia nervosa, bulimia nervosa, obesity, cerebral ischemia, neurodegenerative disease, and diabetic neuropathy.