Imidazo [4, 5-C] quinoline derivatives as bromodomain inhibitors

1. A compound of formula (I) or a salt thereof

wherein:

A is a group selected from the following:

X represents CH or N;

Y represents CH or N with the proviso that when X is N, Y is CH;

R x represents O or S;

R 1 represents C 1-6 alkyl, C 3-6 cycloalkyl, a 5 or 6 membered heterocyclyl, an aromatic group or a heteroaromatic group, wherein the aromatic group or the heteroaromatic group is optionally substituted by one to three groups selected from:

halogen, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-4 alkoxy, haloC 1-4 alkyl, haloC 1-4 -alkoxy, hydroxyC 1-4 alkyl, C 1-4 -alkoxyC 1-4 alkyl, C 1-4 -alkoxycarbonyl, C 1-4 -alkylsulfonyl, C 1-4 -alkylsulfonyloxy, C 1-4 alkylsulfonylC 1-4 alkyl, C 1-4 -alkylsulfonamido;

R 2 is hydrogen or C 1-6 alkyl,

R 2a represents:

H, C 1-6 alkyl, C 1-6 haloallyl, (CH 2 ) m cyano, (CH 2 ) m OH, (CH 2 ) m C 1-6 alkoxy, (CH 2 ) m C 1-6 haloalkoxy, (CH 2 ) m C 1-6 haloalkyl (CH 2 ) m C(O)NR a R b , (CH 2 ) m NR a R b and (CH 2 ) m C(O)CH 3 ,

(CHR 6 ) p phenyl optionally substituted by C 1-6 alkyl, C 1-6 alkoxy, cyano haloC 1-4 -alkoxy, haloC 1-4 -alkyl,

(CHR 6 ) p heteroaromatic, (CHR 6 ) p heterocyclyl,

wherein

R a represents H, C 1-6 alkyl, or heterocyclyl;

R b represents H or C 1-6 alkyl, or

R a and R b together with the N to which they are attached form a 5 or 6 membered heterocyclyl;

R 2b represents H, C 1-6 alkyl, (CH 2 ) 2 C 1-6 alkoxy, (CH 2 ) 2 cyano, (CH 2 ) m phenyl, (CH 2 ) 2 heterocyclyl;

R 3 represents hydrogen;

R 4 represents hydrogen, cyano or C 1-6 alkyl;

Z represents O; or when R 4 represents hydrogen and A is a group selected from (i) or (ii) and wherein R x represents 0, Z may additionally represent NH;

R 5 represents hydrogen or C 1-6 alkoxy;

R 6 represents hydrogen or C 1-6 alkyl;

m represents 1, 2 or 3; and

n represents 0, 1 or 2

p represents 0, 1 or 2.

2. A compound or a salt thereof according to claim 1 which is a compound of formula (IA)

wherein A and R 4 are as defined for formula (I).

3. A compound or a salt thereof according to claim 2 in which R 4 is hydrogen and A is a group of formula (I) or (ii) wherein n is 1.

4. A compound or a salt thereof according to claim 1 in which A is a group of formula (II) wherein R 2b represents (CH 2 ) 2 C 1-6 alkoxy.

5. A compound or a salt thereof according to claim 1 which is a compound of formula (IB)

wherein R 1 , R 2 , R 3 , R 5 and n are as defined for compounds of formula (I).

6. A compound or a salt thereof according to claim 5 in which R 5 is —OCH 3 .

7. A compound or a salt thereof according to claim 1 which is a compound of formula (1C)

wherein R 1 , R 2 , R 3 , R 2a and n are defined above for compounds of formula (I).

8. A compound or a salt thereof according to claim 7 in which R 2a represents H, C 1-3 alkyl, (CH 2 ) m OH, (CH 2 ) m C 1-3 alkoxy, (CH 2 ) m NR a R b or (CHR 6 ) p heterocyclyl,

wherein

R a represents H, C 1-3 alkyl, or heterocyclyl;

R b represents H or C 1-3 alkyl, or

R a and R b together with the N to which they are attached form a 5 or 6 membered heterocyclyl;

R 6 represents H or C 1-3 alkyl;

m represents 1, 2 or 3; and

p represents 0, 1, 2.

9. A compound or a salt thereof according to claim 7 in which R 2a is tetrahydropyranyl.

10. A compound or a salt thereof according to claim 1 in which n is 1.

11. A compound or a salt thereof according to claim 1 in which R 2 is hydrogen or methyl.

12. A compound or a salt thereof according claim 1 in which R 1 represents a heteroaromatic group optionally substituted by one or two groups selected from hydroxy, C 1-3 alkyl, C 1-3 alkoxy, hydroxyC 1-4 -alkyl and C 1-4 alkoxyC 1-4 alkyl.

13. A compound or a salt thereof according to claim 12 in which the heteroaromatic group is pyridyl.

14. A compound or a salt thereof according to claim 12 in which the heteroaromatic group is selected from furanyl, thienyl, isoxazolyl, thiazolyl, pyrazolyl, pyrazinyl and pyrimidinyl.

15. A compound which is any of one of Examples 1-226 or a salt thereof.

16. A compound which is 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-(2-pyridinyl)ethyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one

or a salt thereof.

17. A pharmaceutical composition which comprises a compound or a salt thereof as defined in claim 1 and one or more pharmaceutically acceptable carriers, diluents or excipients.