Ophthalmic device, and method of use thereof, for increasing ocular boundary lubrication
The present invention provides an ophthalmic device, and method of use thereof, for an individual wearing an ophthalmic lens to increase ocular surface boundary lubrication. The invention device comprises an ophthalmic lens and a sacrificial mechanism disposed on the ophthalmic lens, wherein the sacrificial mechanism comprises a plurality of surface bound receptors, such as PRG4, hyaluronic acid, and DNA aptamers, that reversibly bound to a lubricating composition comprising a gel forming agent, a surfactant, or a combination thereof, effectively inhibiting or preventing protein and lipid adsorption on the surface of the lens, and mitigate shear stress and reduce the friction between the lens and the ocular surface of the individual in need.
1. An ophthalmic device comprising an ophthalmic lens with an outer surface and an inner surface and a lubricating composition comprising proteoglycan 4 (PRG4) disposed on at least a portion of the outer or inner surface in an amount effective to provide ocular boundary lubrication in an ocular environment of an individual wearing the ophthalmic lens, and wherein the PRG4 is bound to said surface.
2. The ophthalmic device of claim 1 , wherein the lubricating composition further comprises at least one gel forming agent, a surfactant, or a combination thereof associated with said PRG4.
3. The ophthalmic device of claim 2 , wherein the lubricating composition comprises at least one gel forming agent comprising hyaluronic acid, sodium hyaluronate, or a combination thereof.
4. The ophthalmic device of claim 2 , wherein the surfactant comprises one or more surface active phospholipids.
5. The ophthalmic device of claim 4 , wherein the surface active phospholipid is selected from the group consisting of L-α-dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin.
6. The ophthalmic device of claim 1 , wherein the PRG4 has an average molar mass of between 50 kDa and 400 kDa, and comprises recombinant PRG4, isolated naturally occurring PRG4, or a lubricating fragment thereof.
7. The ophthalmic device of claim 1 , wherein the PRG4 is bound to the ophthalmic lens surface by direct adsorption, hydrophobic ionic binding, covalent binding or by linker chemistries selected from the group consisting of homo- or hetero-bifunctional linkers, N-hydroxy succinimidyl esters, biotin, avidin, streptavidin, maleimide, thiol bonding, amines, hydrazones, dendrimers, and carbodiimides.
8. The ophthalmic device of claim 1 , wherein the lubricating composition further comprises one or more ophthalmically acceptable agents selected from the group consisting of an ophthalmically acceptable demulcent, an ophthalmically acceptable excipient, an ophthalmically acceptable astringent, an ophthalmically acceptable vasoconstrictor, an ophthalmically acceptable emollient, and tear electrolytes.
9. A method for providing ocular boundary lubrication to an individual in need thereof, comprising applying to an eye of the individual an ophthalmic device comprising an ophthalmic lens with an ocular boundary lubricant composition disposed on at least a portion thereof and comprising PRG4 in an amount effective to provide ocular boundary lubrication in an ocular environment in the individual.
10. The method of claim 9 , wherein the individual is in need of treatment for ocular surface hyperosmolarity.
11. The ophthalmic device of claim 1 , wherein the ophthalmic lens is a contact lens.
12. The ophthalmic device of claim 7 , wherein the ophthalmic lens is a contact lens.
13. The method of claim 9 , wherein the ophthalmic lens is a contact lens.