Methods and compounds for treating diseases caused by reactive oxygen species
Provided is a method of treating a patient having an inflammatory disease by using a compound which inhibits the complex I-mediated ROS production, a medicament containing such compound and methods for screening for such compounds.
1. A method of treating a patient having a T-cell mediated inflammatory disease, the method comprising administering to said patient a therapeutically effective amount of a compound which inhibits complex I-mediated ROS production.
2. The method according to claim 1 , wherein the compound is capable of inhibiting reversed electron flux.
3. The method according to claim 2 , wherein the compound belongs to the class of biguanides.
4. The method of claim 3 , wherein the biguanide is metformin or a pharmaceutically acceptable salt thereof.
5. The method according to claim 1 , wherein the compound is capable of destabilizing complex I.
6. The method according to claim 5 , wherein the compound comprises a siRNA molecule wherein the siRNA molecule interferes with the expression of NDUFAF1.
7. The method according to claim 1 , wherein the T-cell mediated inflammatory disease is selected from the group consisting of graft-versus-host disease, lupus erythematosis, sepsis, asthma, psoriasis, atopical dermatitis, and multiple sclerosis.
8. A medicament against a T-cell mediated inflammatory disease, the medicament containing a therapeutically effective amount of a combination of compounds which inhibit complex I-mediated ROS production.
9. The medicament of claim 8 , wherein the compounds which inhibit complex I-mediated ROS production are metformin or a pharmaceutically acceptable salt thereof and a compound which is capable of destabilizing complex I.