IP Library Granted Patent US 8,565,507
Granted Patent B2
US 8,565,507 · App. 12/718,445 · Granted Oct 22, 2013

Automated placental measurement

Inventors: Carolyn M. Salafia (Larchmont, NY); Richard K. Miller (Pittsford, NY)
Assignee: University of Rochester
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Quick Facts
Patent No.
US 8,565,507
App. No.
12/718,445
Granted
Oct 22, 2013
Kind
B2
Abstract

A method for analyzing the placenta in two or three dimensions comprising: selecting one or more placental samples to be analyzed; obtaining a digital image of each placental sample; and performing an analysis on the digital images, wherein a mathematical algorithm is applied to the digital image. The results of the analysis are correlated with data on health outcomes in infants, children, or adults and are used to assess future health risks to a patient.

Claims (26)

1. A method of analyzing a placenta comprising:

(a) selecting the placenta to be analyzed;

(b) obtaining a digital image of an entire chorionic surface of the placenta;

(c) inputting the digital image into a processor; and

(d) performing an analysis on the digital image in the processor, wherein the processor applies a mathematical algorithm to the digital image in which the algorithm does not include the step of comparing the sample image to a known or reference image.

2. The method of claim 1 , wherein the mathematical algorithm analyzes a placental shape, placental diameter, major or minor axes, placental circumference, centrality of umbilical cord location, or placental area.

3. The method of claim 1 , wherein the mathematical algorithm is used to assess the timing of an event or stress to the developing placenta or fetus.

4. The method of claim 3 , wherein results of timing of an event or stress are used to assess future health risks to a patient.

5. A system for analyzing a placenta and histology slides of placental tissue comprising:

a source of a digital image of the placenta;

a processor, in communication with the source, for performing an analysis on the digital image in the processor, wherein the processor applies a mathematical algorithm to the digital image in which the algorithm does not include the step of comparing the sample ma e to a known or reference image; and

an output, in communication with the processor, for outputting the analysis.

6. The system of claim 5 , wherein the processor is configured such that the mathematical algorithm analyzes a placental shape, placental diameter, major or minor axes, placental circumference, centrality of umbilical cord location, or placental area.

7. The system of claim 5 , wherein the processor is configured such that results of timing of an event or stress are used to assess future health risks to a patient.

8. A system for analyzing a placenta comprising:

a source for a digital image of each placental sample from the placenta;

a processor, in communication with the source, for performing an analysis on the digital images, wherein a mathematical algorithm is applied to the digital images to reconstruct a three dimensional model of the placenta in which the algorithm does not include the step of comparing the sample image to a known or reference image; and

an output for outputting the analysis.

9. The system of claim 8 , wherein the processor is configured such that the mathematical algorithm analyzes a three dimensional placental shape, placental thickness, or placental volume.

10. The system of claim 8 , wherein the processor is configured such that results of timing of an event or stress are used to assess future health risks to a patient.

11. An article of manufacture for analyzing a placenta and histology slides of placental tissue comprising:

a non-transitory computer-readable storage medium, and

code stored on the medium, the code, when executed on a processor, controlling the processor for performing an analysis on a digital image of a placental sample from the placenta, wherein the processor applies a mathematical algorithm to the digital image in which the algorithm does not include the step of comparing the sample image to a known or reference image.

12. An article of manufacture for analyzing a placenta comprising:

a non-transitory computer-readable storage medium, and

code stored on the medium, the code, when executed on a processor, controlling the processor for performing an analysis on digital images of a plurality of placental samples from the placenta, wherein a mathematical algorithm is applied to the digital images to reconstruct a three dimensional model of the placenta in which the algorithm does not include the step of comparing the sample image to a known or reference image.

Assignments (2)
CONFIRMATORY LICENSE Recorded Aug 26, 2015
From: UNIVERSITY OF ROCHESTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 036475/0312 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 18, 2010
From: SALAFIA, CAROLYN M.; MILLER, RICHARD K.
To: UNIVERSITY OF ROCHESTER; PLACENTAL ANALYTICS LLC
Reel/Frame 024403/0788 →
Continuity (3)
Continuation In Part 12153724 · May 23, 2008
Provisional Application 61202510 · Mar 6, 2009
Related Publication 20100220916A1 · Sep 2, 2010