IP Library Granted Patent US 8,571,289
Granted Patent B2
US 8,571,289 · App. 12/471,981 · Granted Oct 29, 2013

System and method for generating a 2D image from a tomosynthesis data set

Inventors: Chris Ruth (Boxford, MA); Andrew Smith (Lexington, MA); Jay Stein (Boston, MA)
Assignee: Hologic, Inc.
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Quick Facts
Patent No.
US 8,571,289
App. No.
12/471,981
Granted
Oct 29, 2013
Kind
B2
Abstract

A 2D mammogram image is synthesized from at least one of tomosynthesis projection images and/or the tomosynthesis reconstructed image data. In a simplest form, the mammogram may be synthesized by selecting one of the tomosynthesis projection images for display as a synthesized mammogram. Other methods of synthesizing a mammogram include re-projecting and filtering projection data and/or reconstructed data. The synthesized mammogram is advantageously displayed together with at least a portion of the reconstructed data to aid in review of the reconstructed data. The present invention thus provides a familiar image which may be used to facilitate review of a tomosynthesis data set.

Claims (21)

1. A method comprising:

obtaining a plurality of x-ray tomosynthesis projection images of a patient's breast;

reconstructing the plurality of x-ray tomosynthesis projection images into a three dimensional reconstructed image comprising a plurality of slices; and

synthesizing a two-dimensional mammogram using at least a subset of the three-dimensional reconstructed image, wherein the step of synthesizing includes projecting at least one tomosynthesis slice image having a pixel spacing that differs from a pixel spacing of a mammogram onto a mammogram coordinate system; and

displaying the synthesized mammogram on a display device.

2. The method of claim 1 including the step of filtering at least one of the x-ray tomosynthesis projection images prior to the step of synthesizing.

3. The method of claim 1 wherein the step of reconstructing the plurality of tomosynthesis projection images reconstructs the tomosynthesis projection images onto a first coordinate system to provide an initial reconstruction.

4. The method of claim 3 including the step of wherein the initial reconstruction is the three-dimensional reconstructed image.

5. The method of claim 3 wherein the first coordinate system is selected from a group including a Cartesian coordinate system, a cone beam coordinate system and a coordinate system associated with a virtual acquisition system.

6. The method of claim 3 wherein the step of reconstructing the plurality of tomosynthesis projection images includes the step projecting the initial reconstruction onto a second, different coordinate system to provide the three-dimensional reconstructed image.

7. The method of claim 6 wherein the second coordinate system is selected from a group including a Cartesian coordinate system, a cone beam coordinate system and a coordinate system associated with a virtual acquisition system.

8. The method of claim 3 wherein the step of reconstructing includes the step of orienting said three-dimensional reconstructed tomosynthesis image to a selected plane.

9. A method comprising:

obtaining a plurality of x-ray tomosynthesis projection images of a patient's breast;

reconstructing the plurality of x-ray tomosynthesis projection images into a three dimensional reconstructed image comprising a plurality of slices, wherein the step of reconstructing the plurality of tomosynthesis projection images reconstructs the tomosynthesis projection images onto a first coordinate system to provide a three-dimensional reconstructed image and wherein the first coordinate system is selected from a group including a Cartesian coordinate system, a cone beam coordinate system and a coordinate system associated with a virtual acquisition system;

synthesizing a two-dimensional mammogram using at least a subset of the three-dimensional reconstructed image; and

displaying the synthesized mammogram on a display device.

10. The method of claim 9 wherein the step of reconstructing the plurality of tomosynthesis projection images includes the step projecting the initial reconstruction onto a second, different coordinate system to provide the three-dimensional reconstructed image.

11. The method of claim 10 wherein the second coordinate system is selected from a group including a Cartesian coordinate system, a cone beam coordinate system and a coordinate system associated with a virtual acquisition system.

12. The method of claim 9 wherein the step of reconstructing includes the step of orienting said three-dimensional reconstructed tomosynthesis image to a selected plane.

13. The method of claim 9 wherein the step of synthesizing includes projecting at least one tomosynthesis slice image having a pixel spacing that differs from a pixel spacing of a mammogram onto a mammogram coordinate system.

Assignments (10)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 035820 FRAME: 0239. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY INTEREST RELEASE. Recorded Nov 9, 2017
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 044727/0529 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 028810 FRAME: 0745. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Nov 9, 2017
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 044432/0565 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 028810/0745 Recorded Jun 4, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035820/0239 →
SECURITY AGREEMENT Recorded Aug 1, 2012
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 028810/0745 →
TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS Recorded Aug 26, 2010
From: GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT
To: HOLOGIC, INC.; R2 TECHNOLOGY, INC.; SUROS SURGICAL SYSTEMS, INC.; BIOLUCENT, LLC; DIRECT RADIOGRAPHY CORP.; CYTYC SURGICAL PRODUCTS II LIMITED PARTNERSHIP; CYTYC SURGICAL PRODUCTS LIMITED PARTNERSHIP; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS III, INC.; CYTYC PRENATAL PRODUCTS CORP.; THIRD WAVE TECHNOLOGIES, INC.
Reel/Frame 024892/0001 →
CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF THE ASSIGNEE. DOCUMENT PREVIOUSLY RECORDED AT REEL 022947 FRAME 0852. ASSIGNOR(S) HEREBY CONFIRMS THE HOLOGIC, INC. Recorded Jul 14, 2009
From: FUTH, CHRISTOPHER; SMITH, ANDREW; STEIN, JAY
To: HOLOGIC, INC.
Reel/Frame 022961/0440 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 13, 2009
From: RUTH, CHRISTOPHER; SMITH, ANDREW; STEIN, JAY
To: HOOGIC, INC.
Reel/Frame 022947/0852 →
11TH SUPPLEMENT TO PATENT SECURITY AGREEMENT Recorded Jul 1, 2009
From: HOLOGIC, INC.
To: GOLDMAN SACHS CREDIT PARTNERS L.P., AS COLLATERAL AGENT
Reel/Frame 022892/0922 →
Continuity (9)
Continuation In Part 12276006 · Nov 21, 2008
Continuation In Part 11827909 · Jul 13, 2007
Continuation 11604069 · Nov 24, 2006
Continuation In Part 11271050 · Nov 11, 2005
Continuation In Part 10305480 · Nov 27, 2002
Continuation In Part 10723486 · Nov 26, 2003
Provisional Application 60628516 · Nov 15, 2004
Provisional Application 60631296 · Nov 26, 2004
Related Publication 20100135558A1 · Jun 3, 2010