Composite bone repair material
The present invention relates to a sliceable composite bone repair material comprising a porous block-shaped ceramic scaffold and a stabilizing polymer disposed therein. Said ceramic scaffold is a synthetic ceramic material or a naturally-derived material. Additionally said scaffold comprises interconnected macropores.
1. A sliceable composite bone repair material comprising:
a porous block-shaped scaffold comprising a bone substitute material comprising a synthetic ceramic material, and wherein said scaffold comprises interconnected macropores; and
a stabilizing polymer disposed therein, wherein the stabilizing polymer is a degradable polyethylene glycol hydrogel formed by a cross-linking Michael-type addition reaction of at least two precursor molecules, wherein said cross-linking reaction forms an ester linkage between the at least two precursor molecules, and
wherein said hydrogel is degradable in water.
2. Composite bone repair material of claim 1 wherein the scaffold is a synthetic ceramic material comprising a calcium phosphate.
3. Composite bone repair material of claim 2 wherein the calcium phosphate is selected from the group consisting of hydroxyapatite and tricalcium phosphate or a mixture thereof.
4. Composite bone repair material according to claim 1 wherein the ceramic scaffold has a total porosity between 75% and 95%.
5. Composite bone repair material according to claim 1 wherein the ceramic scaffold has at least a second portion with enhanced mechanical strength similar to cortical bone.
6. Composite bone repair material according to claim 1 further comprising a bioactive agent.
7. Composite bone repair material of claim 6 , wherein the bioactive agent is released from the stabilizing polymer.
8. Composite bone repair material of claim 6 , wherein the bioactive agent is selected from the group of parathyroid hormone, bone morphogenic protein and enamel matrix derivatives.
9. A device for the treatment of oral bone defects including the composite bone repair material of claim 1 .
10. A kit for preparing a composite bone repair material according to claim 1 comprising the porous block-shaped synthetic ceramic scaffold and the stabilizing polymer.
11. A kit according to claim 10 comprising:
a) the porous block-shaped synthetic ceramic scaffold;
b) a multi-arm PEG-thiol;
c) a multi-arm PEG-acrylate, wherein the total number of arms is equal or larger than five; and
d) buffers for the multi-arm PEG-thiol and multi-arm PEG-acrylate.
12. A kit according to claim 10 additionally comprising a bioactive agent.
13. A kit according to claim 11 additionally comprising a bioactive agent premixed either with the multi-arm PEG-thiol or with the multi-arm PEG-acrylate.