Amino-pyrrolidine-azetidine diamides as monoacylglycerol lipase inhibitors

1. A compound of Formula (I)

wherein

Y is a C 6-10 aryl or a heteroaryl selected from the group consisting of thiazolyl, thienyl, benzofuranyl, and benzothienyl; wherein Y is unsubstituted or substituted with one or two fluoro substituents;

Z is

i) a C 6-10 aryl;

ii) 9H-fluorenyl;

iii) phenyl-(R a )-phenyl wherein the phenyl ring on phenyl-(R a )— is unsubstituted or substituted with one substituent that is trifluoromethyl;

R a is CH(F), CF 2 , or CH(OH);

iv) a benzo-fused heterocyclyl selected from the group consisting of 1,2,3,4-tetrahydroisoquinolinyl, isoindolinyl, and indolinyl;

wherein the benzo-fused heterocyclyl is unsubstituted or substituted with one substituent that is phenyl or bromo, wherein said phenyl is unsubstituted or substituted with one substituent selected from the group consisting of bromo, chloro, fluoro, methyl, methoxy, or trifluoromethyl; or

v) a heteroaryl selected from the group consisting thiazolyl, benzothienyl, benzofuranyl, benzothiazolyl, quinazolinyl, indolyl, and indazolyl;

wherein the C 6-10 aryl and the heteroaryl of Z are unsubstituted or substituted with one or two substitutents each of which is independently selected from the group consisting of bromo, chloro, fluoro, C 1-4 alkyl, C 2-4 alkenyl, trifluoromethyl, trifluoromethoxy, and R b ; provided that no more than one substituent is R b ; and

R b is selected from the group consisting of 2,2-difluoroethyl; phenylmethyl; C 3-6 cycloalkyl; N-methyl-N-phenylaminocarbonyl-methyl; thienyl; pyrimidinyl; and phenyl; wherein the phenyl portion of phenylmethyl, and said thienyl, pyrimidinyl, and phenyl of R b are unsubstituted or substituted with one or two substituents each of which is independently selected from the group consisting of trifluoromethyl, trifluoromethoxy, chloro, and fluoro;

R 1 is hydrogen, fluoro or hydroxy;

R 2 is hydrogen, methyl, or hydroxy;

and enantiomers, diastereomers, and pharmaceutically acceptable salt forms thereof.

2. A compound of Formula (I)

wherein

Y is an unsubstituted C 6-10 aryl or an unsubstituted heteroaryl that is thienyl or thiazolyl;

Z is

i) a C 6-10 aryl;

ii) 9H-fluorenyl;

iii) phenyl-(R a )-phenyl wherein the phenyl ring on phenyl-(R a )— is unsubstituted or substituted with one substituent that is trifluoromethyl;

R a is CH(F), CF 2 , or CH(OH);

iv) a benzo-fused heterocyclyl selected from the group consisting of 1,2,3,4-tetrahydroisoquinolinyl, isoindolinyl, and indolinyl; wherein the benzo-fused heterocyclyl is unsubstituted or substituted with one substituent that is phenyl or bromo; or

v) a heteroaryl selected from the group consisting thiazolyl, benzothienyl, benzofuranyl, benzothiazolyl, quinazolinyl, indolyl, and indazolyl;

wherein the C 6-10 aryl and the heteroaryl of Z are unsubstituted or substituted with one or two substitutents each of which is independently selected from the group consisting of bromo, chloro, fluoro, C 1-4 -alkyl, C 2-4 alkenyl, trifluoromethyl, trifluoromethoxy, and R b ; provided that no more than one substituent is R b ;

R b is selected from the group consisting of phenylmethyl; C 3-6 cycloalkyl; thienyl; pyrimidinyl; and phenyl; wherein the phenyl portion of phenylmethyl, and said thienyl and said phenyl of R b are unsubstituted or substituted with one or two substituents each of which is independently selected from the group consisting of trifluoromethyl, trifluoromethoxy, chloro, and fluoro;

R 1 is hydrogen or fluoro;

R 2 is hydrogen, C 1-2 alkyl, or hydroxy;

and enantiomers, diastereomers, and pharmaceutically acceptable salt forms thereof.

3. A compound of Formula (I)

wherein

Y is an unsubstituted phenyl or an unsubstituted heteroaryl that is thienyl or thiazolyl;

Z is

i) a C 6-10 aryl;

ii) 9H-fluorenyl;

iii) phenyl-(R a )-phenyl wherein the phenyl ring on phenyl-(R a )— is unsubstituted or substituted with one substituent that is trifluoromethyl;

R a is CF 2 or CH(OH);

iv) indolinyl and said indolinyl is unsubstituted or substituted with one substituent that is phenyl or bromo; or

v) a heteroaryl selected from the group consisting benzothienyl, benzofuranyl, indolyl, and indazolyl;

wherein the C 6-10 aryl and the heteroaryl of Z are unsubstituted or substituted with one or two substituents each of which is independently selected from the group consisting of bromo, chloro, fluoro, C 1-4 alkyl, C 2-4 alkenyl, trifluoromethyl, trifluoromethoxy, and R b ; provided that no more than one substituent is R b ; and

R b is selected from the group consisting of phenylmethyl; thienyl; pyrimidinyl; and phenyl; wherein the phenyl portion of phenylmethyl, and said thienyl and said phenyl of R b are unsubstituted or substituted with one or two substituents each of which is independently selected from the group consisting of trifluoromethyl, chloro, and fluoro;

R 1 is hydrogen or fluoro;

R 2 is hydrogen, C 1-2 alkyl, or hydroxy;

and enantiomers, diastereomers, and pharmaceutically acceptable salt forms thereof.

4. A compound of Formula (I)

wherein

Y is an unsubstituted phenyl or an unsubstituted heteroaryl that is thienyl or thiazolyl;

Z is

i) a C 6-10 aryl;

ii) phenyl-(R a )-phenyl wherein the phenyl ring on phenyl-(R a )— is unsubstituted or substituted with one substituent that is trifluoromethyl;

R a is CF 2 or CH(OH);

iii) indolinyl and said indolinyl is unsubstituted or substituted with one substituent that is phenyl or bromo; or

iv) a heteroaryl selected from the group consisting benzothienyl, benzofuranyl, indolyl, and indazolyl;

wherein the C 6-10 aryl and the heteroaryl of Z are unsubstituted or substituted with one or two substitutents each of which is independently selected from the group consisting of bromo, chloro, fluoro, C 1-4 -alkyl, C 2-4 alkenyl, trifluoromethyl, trifluoromethoxy, and R b ; provided that no more than one substituent is R b ;

R b is selected from the group consisting of phenylmethyl; thienyl; pyrimidinyl; and phenyl; wherein the phenyl portion of phenylmethyl, and said thienyl and said phenyl of R b are unsubstituted or substituted with one or two substituents each of which is independently selected from the group consisting of trifluoromethyl, chloro, and fluoro;

R 1 is hydrogen or fluoro;

R 2 is hydrogen;

and enantiomers, diastereomers, and pharmaceutically acceptable salt forms thereof.

5. A compound of Formula (I)

selected from the group consisting of

(3S)—N-[1-(Biphenyl-4-ylcarbonyl)azetidin-3-yl]-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-(Biphenyl-4-ylcarbonyl)azetidin-3-yl]-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(4-Benzylphenyl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(4-Benzylphenyl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(4-Benzylphenyl)carbonyl]azetidin-3-yl}-1-(thiophen-3-ylcarbonyl)pyrrolidin-3-amine,

(3R)—N-{1-[(4-Benzylphenyl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3R)—N-{1-[(4-Benzylphenyl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Bromo-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Phenyl-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(5-Bromo-1,3-dihydro-2H-isoindol-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(5-Phenyl-1,3-dihydro-2H-isoindol-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(4-Benzylphenyl)carbonyl]azetidin-3-yl}-N-methyl-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-Methyl-1-(phenylcarbonyl)-N-(1-{[3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-(1-{[3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)—N-{1-[(3′,5′-Dichlorobiphenyl-4-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-(1-{[5-(trifluoromethoxy)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-(1-{[5-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-(1-{[6-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Bromo-3-chloro-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(5-Bromonaphthalen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-{1-[(5-phenylnaphthalen-2-yl)carbonyl]azetidin-3-yl}pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({5-[2-(trifluoromethyl)phenyl]naphthalen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({5-[3-(trifluoromethyl)phenyl]naphthalen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({5-[4-(trifluoromethoxy)phenyl]naphthalen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-[1-(9H-Fluoren-2-ylcarbonyl)azetidin-3-yl]-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Chloro-6-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3′-Chlorobiphenyl-4-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3′,4′-Dichlorobiphenyl-4-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Chloro-6-phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Chloro-6-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Chloro-6-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(5-Bromonaphthalen-2-yl)carbonyl]azetidin-3-yl}-N-hydroxy-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-(1-{[4′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-(1-{[4′-(trifluoromethoxy)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)—N-{1-[(5-Chloro-3-methyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Bromo-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Methyl-5-phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Methyl-5-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Methyl-5-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({6-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({6-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-[1-(Biphenyl-4-ylcarbonyl)azetidin-3-yl]-1-[(4-fluorophenyl)carbonyl]pyrrolidin-3-amine,

(3S)—N-[1-(Biphenyl-4-ylcarbonyl)azetidin-3-yl]-1-[(3-fluorophenyl)carbonyl]pyrrolidin-3-amine,

(3S)-1-(1-Benzofuran-2-ylcarbonyl)-N-[1-(biphenyl-4-ylcarbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(1-Benzothiophen-2-ylcarbonyl)-N-[1-(biphenyl-4-ylcarbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-{1-[(5-Bromo-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(5-Phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({5-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({5-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-Ethyl-1-(phenylcarbonyl)-N-(1-{[3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)—N-Hydroxy-1-(phenylcarbonyl)-N-(1-{[3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Bromo-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Chloro-6-fluoro-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-{1-[(3-phenyl-1H-indol-6-yl)carbonyl]azetidin-3-yl}pyrrolidin-3-amine,

N-[1-(Biphenyl-4-ylcarbonyl)azetidin-3-yl]-4-fluoro-1-(phenylcarbonyl)pyrrolidin-3-amine,

4-Fluoro-1-(phenylcarbonyl)-N-(1-{[3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3R)—N-[1-(Biphenyl-4-ylcarbonyl)azetidin-3-yl]-4-fluoro-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-(Biphenyl-4-ylcarbonyl)azetidin-3-yl]-4-fluoro-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3R)-4-Fluoro-1-(phenylcarbonyl)-N-(1-{[3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)-4-Fluoro-1-(phenylcarbonyl)-N-(1-{[3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)—N-{1-[(1-Methyl-3-phenyl-1H-indol-6-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Cyclopropyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

{4-[(3-{[(3S)-1-(Phenylcarbonyl)pyrrolidin-3-yl]amino}azetidin-1-yl)carbonyl]phenyl}[4-(trifluoromethyl)phenyl]methanol,

(3S)—N-{1-[(3-Methyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

N-{1-[(4-{Fluoro[4-(trifluoromethyl)phenyl]methyl}phenyl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Cyclopropyl-6-fluoro-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3R,4R)-4-Methoxy-1-(phenylcarbonyl)-N-(1-{[3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3R,4R)-1-(Phenylcarbonyl)-4-[(1-{[3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)amino]pyrrolidin-3-ol,

(3S)—N-[1-({4-[Difluoro(phenyl)methyl]phenyl}carbonyl)azetidin-3-yl]-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-(1-{[3-phenyl-6-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Cyclopropyl-6-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(2-Methylprop-1-en-1-yl)-6-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({4-[4-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3R,4R)-4-{[1-(Biphenyl-4-ylcarbonyl)azetidin-3-yl]amino}-1-(phenylcarbonyl)pyrrolidin-3-ol,

(3S)—N-{1-[(3-Cyclobutyl-6-fluoro-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Methyl-6-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

N-{1-[(5-Chloro-3-methyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-N-[(3S)-1-(phenylcarbonyl)pyrrolidin-3-yl]formamide,

N-{1-[(5-Chloro-3-methyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-N-[(3S)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-yl]formamide,

N-{1-[(5-Chloro-3-methyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-N-[(3S)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-yl]formamide,

(3S)—N-{1-[(5-Chloro-3-methyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(5-Chloro-3-methyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Fluoro-3-methyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Fluoro-3-methyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Fluoro-3-methyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Fluoro-6-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Methyl-5-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Methyl-5-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Methyl-5-phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[5-(3-Fluorophenyl)-3-methyl-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[5-(4-Fluorophenyl)-3-methyl-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Bromo-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Bromo-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(5-Bromo-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(5-Bromo-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-2-ylcarbonyl)-N-[1-({6-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-4-ylcarbonyl)-N-[1-({6-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({3-[4-(trifluoromethyl)phenyl]-1H-indol-6-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-2-ylcarbonyl)-N-[1-({6-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({3-[3-(trifluoromethyl)phenyl]-1H-indol-6-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-2-ylcarbonyl)-N-[1-({3-[4-(trifluoromethyl)phenyl]-1H-indol-6-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-2-ylcarbonyl)-N-[1-({3-[3-(trifluoromethyl)phenyl]-1H-indol-6-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-4-ylcarbonyl)-N-[1-({3-[3-(trifluoromethyl)phenyl]-1H-indol-6-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-{1-[(5-Bromo-1-benzofuran-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-{1-[(4-phenylquinazolin-7-yl)carbonyl]azetidin-3-yl}pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({4-[4-(trifluoromethyl)phenyl]quinazolin-7-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-{1-[(4-Phenylquinazolin-7-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-2-ylcarbonyl)-N-[1-({4-[4-(trifluoromethyl)phenyl]quinazolin-7-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-{1-[(4-Phenylquinazolin-7-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-2-ylcarbonyl)-N-(1-{[3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-4-ylcarbonyl)-N-(1-{[3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-2-ylcarbonyl)-N-(1-{[4′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Fluoro-3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Methyl-3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-2-ylcarbonyl)-N-[1-({1-[4-(trifluoromethyl)phenyl]-1H-indol-5-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-{1-[(1-Pyrimidin-2-yl-1H-indol-5-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(1-Phenyl-1H-indazol-5-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(5-Phenyl-1-benzofuran-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[5-(5-Chlorothiophen-2-yl)-1-benzofuran-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Methyl-5-phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Methyl-5-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({4-[3-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-4-ylcarbonyl)-N-[1-({4-[3-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-4-ylcarbonyl)-N-[1-({6-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-{1-[(5-Phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-4-ylcarbonyl)-N-[1-({5-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-{1-[(5-Phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-2-ylcarbonyl)-N-[1-({5-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-{1-[(2-Phenyl-1,3-benzothiazol-6-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[2-(2-Fluorophenyl)-4-methyl-1,3-thiazol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[2-(4-Fluorophenyl)-4-methyl-1,3-thiazol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[2-(3-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-2-ylcarbonyl)-N-(1-{[6-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-4-ylcarbonyl)-N-(1-{[6-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Bromo-3-chloro-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(6-Bromo-3-chloro-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Fluoro-1-(4-fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Fluoro-1-(4-fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-4-ylcarbonyl)-N-[1-({4-[4-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-4-ylcarbonyl)-N-(1-{[4′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Chloro-6-phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Chloro-6-phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Chloro-6-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Chloro-6-[3-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Chloro-6-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Chloro-6-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Fluoro-3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Methyl-3′-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-[1-({1-[4-(trifluoromethyl)phenyl]-1H-indol-5-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-{1-[(1-pyrimidin-2-yl-1H-indol-5-yl)carbonyl]azetidin-3-yl}pyrrolidin-3-amine,

(3S)-1-(Phenylcarbonyl)-N-{1-[(1-phenyl-1H-indazol-5-yl)carbonyl]azetidin-3-yl}pyrrolidin-3-amine,

(3S)—N-{1-[(2-Phenyl-1,3-benzothiazol-6-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)-1-(1,3-Thiazol-4-ylcarbonyl)-N-[1-({1-[4-(trifluoromethyl)phenyl]-1H-indol-5-yl}carbonyl)azetidin-3-yl]pyrrolidin-3-amine,

(3S)—N-(1-{[1-(4-Fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[1-(4-Fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[1-(4-Fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({1-Methyl-3-[3-(trifluoromethyl)phenyl]-1H-indol-6-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({1-Methyl-3-[4-(trifluoromethyl)phenyl]-1H-indol-6-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({1-Methyl-3-[3-(trifluoromethyl)phenyl]-1H-indol-6-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({1-Methyl-3-[4-(trifluoromethyl)phenyl]-1H-indol-6-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({1-Methyl-3-[3-(trifluoromethyl)phenyl]-1H-indol-6-yl}carbonyl)azetidin-3-yl]-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Chloro-6-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-Chloro-6-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(1-Methyl-3-phenyl-1H-indol-6-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(1-Methyl-3-phenyl-1H-indol-6-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Fluoro-5-phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Fluoro-5-phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Fluoro-5-phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Fluoro-5-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Fluoro-5-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Fluoro-5-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Fluoro-6-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Fluoro-6-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-[1-({3-Fluoro-6-[4-(trifluoromethyl)phenyl]-1-benzothiophen-2-yl}carbonyl)azetidin-3-yl]-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[5-Chloro-3-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[5-Chloro-3-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[6-Chloro-3-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[6-Chloro-3-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[5-Methyl-3-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[6-Methyl-3-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[6-Methyl-3-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Phenyl-1H-indol-6-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(3-Phenyl-1H-indol-6-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(4-Fluorophenyl)-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(4-Fluorophenyl)-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(4-Fluorophenyl)-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(4-Fluorophenyl)-1-methyl-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(4-Fluorophenyl)-1-methyl-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(4-Fluorophenyl)-1-methyl-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(1-Methyl-3-phenyl-1H-indazol-5-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(1-Methyl-3-phenyl-1H-indazol-5-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-{1-[(1-Methyl-3-phenyl-1H-indazol-5-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[4-Fluoro-1-(4-fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(3-Fluorophenyl)-1-methyl-1H-indazol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(3-Fluorophenyl)-1-methyl-1H-indazol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(3-Fluorophenyl)-1-methyl-1H-indazol-5-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(3-Fluorophenyl)-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(3-Fluorophenyl)-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(3-Fluorophenyl)-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(3-Fluorophenyl)-1-methyl-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(3-Fluorophenyl)-1-methyl-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(3-Fluorophenyl)-1-methyl-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[6-Phenyl-3-(trifluoromethyl)-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(4-Fluorophenyl)-1-methyl-1H-indazol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(4-Fluorophenyl)-1-methyl-1H-indazol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(4-Fluorophenyl)-1-methyl-1H-indazol-5-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[6-Fluoro-1-(4-fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3R)—N-(1-{[1-(2,2-Difluoroethyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[1-(4-Fluorophenyl)-1H-indol-4-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[1-(4-Fluorophenyl)-1H-indol-4-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[1-(4-Fluorophenyl)-2,3-dihydro-1H-indol-4-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[1-(4-Fluorophenyl)-2,3-dihydro-1H-indol-4-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-4-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[1-(3-Fluorophenyl)-1H-indol-3-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[1-(4-Fluorophenyl)-1H-indol-3-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[1-(4-Fluorophenyl)-2,3-dihydro-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[3-(4-Fluorobenzyl)-1-methyl-1H-indol-6-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

N-Methyl-N-phenyl-2-{5-[(3-{[(3S)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-yl]amino}azetidin-1-yl)carbonyl]-1H-indol-1-yl}acetamide,

(3S)—N-(1-{[4-Chloro-1-(4-fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

(3S)—N-(1-{[1-(4-Fluorophenyl)-6-methyl-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine, and

(3S)—N-(1-{[6-Chloro-1-(4-fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine,

and pharmaceutically acceptable salt forms thereof.

6. A pharmaceutical composition comprising the compound of claim 1 or 5 and a member selected from the group consisting of a pharmaceutically acceptable carrier, a pharmaceutically acceptable excipient, and a pharmaceutically acceptable diluent.

7. A pharmaceutical composition of claim 6 , wherein the composition is a solid oral dosage form.

8. A pharmaceutical composition of claim 6 , wherein the composition is selected from the group consisting of a syrup, an elixir, and a suspension.

9. A method for treating inflammatory pain in a subject in need thereof comprising administering a therapeutically effective amount of the compound of claim 1 or 5 to the subject.

10. The method of claim 9 wherein the inflammatory pain is due to inflammatory bowel disease, visceral pain, migraine, post operative pain, osteoarthritis, rheumatoid arthritis, back pain, lower back pain, joint pain, abdominal pain, chest pain, labor, musculoskeletal diseases, skin diseases, toothache, pyresis, burn, sunburn, snake bite, venomous snake bite, spider bite, insect sting, neurogenic bladder, interstitial cystitis, urinary tract infection, rhinitis, contact dermatitis/hypersensitivity, itch, eczema, pharyngitis, mucositis, enteritis, irritable bowel syndrome, cholecystitis, pancreatitis, postmastectomy pain syndrome, menstrual pain, endometriosis, pain, pain due to physical trauma, headache, sinus headache, tension headache, or arachnoiditis.