Furanone compounds and lactam analogues thereof
The present invention provides a compound of formula I and a compound of formula II, methods of use and formulations thereof.
1. A compound of formula I
wherein:
X is —N(R 5 )—;
wherein R 5 is selected from H, alkyl, aryl and arylalkyl;
R 1 is phenyl substituted by a substituent selected from the group consisting of CF 3 , OCF 3 , cyano and halo;
R 2 and R 4 are each independently selected from hydrogen and aryl with the proviso that both R 2 and R 4 cannot be hydrogen; and
R 3 is selected from H, alkyl, heteroaryl and aryl.
2. A compound according to claim 1 wherein R 4 is H.
3. A compound according to claim 1 wherein R 3 is H.
4. A compound according to claim 1 wherein R 2 is aryl.
5. A compound according to claim 4 wherein aryl is a phenyl group optionally substituted with one or more substituents selected from the group consisting of CF 3 , OCF 3 , cyano, halo, alkoxyl and methoxyl.
6. A compound according to claim 1 wherein aryl is a phenyl group optionally substituted with one or more substituents selected from the group consisting of CF 3 , OCF 3 , cyano, halo and.
7. A compound according to claim 1 wherein R 1 is phenyl substituted by a substituent selected from the group consisting of CF 3 , OCF 3 , cyano, and halo and R 2 is aryl.
8. A formulation comprising a compound according to claim 1 .
9. A compound according to claim 1 wherein R 1 is phenyl substituted by a substituent selected from the group consisting of CF 3 , OCF 3 , cyano and F.
10. A compound according to claim 1 wherein X is N; R 5 is H; R 1 is phenyl with F substituted in the 2-position; R 2 is phenyl; R 3 is H and R 4 is H.