Methods and devices for brain cooling for treatment and prevention of acquired epilepsy
A device for cooling the central nervous system (e.g., the brain) is disclosed that is specifically designed to provide cooling of an injured central nervous system for neuroprotective, antiepileptogenic, and/or antiepileptic treatments. In one embodiment, a portion of the cooling device is placed in a recess formed by removal of a portion of a patient's skull. An embedded heat-collecting portion of the cooling device is formed to fit in the location of the formed recess and a thermally conductive material of the heat-collecting portion is placed adjacent the dura mater to provide the desired degree of cooling. A heat-dissipating external plate is in thermal contact with the internal plate, and can be selectively sized according to a specific purpose.
1. A method for mitigating or preventing epilepsy by focally cooling a brain, the method comprising:
removing a portion of a cranium through an incision in a scalp of a patient to form a recess in which a portion of dura mater is exposed; and
implanting a cooling device adjacent the exposed portion of dura mater and closing the incision such that an adjacent portion of the brain is cooled by the cooling device by heat dissipation through the scalp, and wherein the adjacent portion of the brain is cooled by not more than 4° C.,
wherein the cooling device comprises a passive cooling device having a highly thermally conductive portion adjacent the exposed portion of dura mater.
2. The method of claim 1 , wherein the portion of the brain is cooled by the cooling device by about 2° C.
3. The method of claim 1 , wherein the cooling device does not cause a core body temperature of the patient to decrease.
4. The method of claim 1 , wherein the cooling device does not penetrate the dura mater.
5. The method of claim 1 , wherein the highly thermally conductive portion comprises a core and an outer portion encasing the core.
6. The method of claim 5 , wherein the core is a non-biocompatible material and the outer portion is a biocompatible material.
7. The method of claim 1 , wherein the highly thermally conductive portion comprises a metal plate having an inner face, and a polymeric layer disposed between the metal plate inner face and the patient dura mater.
8. The method of claim 1 , wherein the cooling device cools the portion of the brain for an extended period of time comprising more than two days.
9. The method of claim 1 , wherein the cooling device further comprises at least one thermally conductive subdermal cooling strip configured to extend laterally between the scalp and the cranium.
10. The method of claim 1 , wherein the cooling device further comprises a thermally conductive cushion on a proximal face that is in contact with the exposed portion of dura mater.
11. The method of claim 10 , wherein the thermally conductive cushion comprises a silicone sack filled with a fluid.
12. The method of claim 11 , wherein the thermally conductive cushion further comprises thermally conductive filaments disposed with the silicone sack.
13. The method of claim 1 , wherein the cooling device further comprises a plurality of thermally conductive cooling strips that directly engage the dura mater.
14. A method for mitigating or preventing epilepsy by focally cooling a brain, the method comprising:
removing a portion of a cranium through an incision in a scalp of a patient to form a recess in which a portion of dura mater is exposed; and
implanting a cooling device adjacent the exposed portion of dura mater and closing the incision such that an adjacent portion of the brain is cooled by the cooling device by heat dissipation through the scalp, and wherein the adjacent portion of the brain is cooled by not more than 4° C.,
wherein the cooling device further comprises a thermally conductive cushion on a proximal face that is in contact with the exposed portion of dura mater, the thermally conductive cushion comprising a silicone sack filled with a fluid and thermally conductive filaments disposed within the silicone sack.