IP Library Granted Patent US 8,591,956
Granted Patent B2
US 8,591,956 · App. 13/205,229 · Granted Nov 26, 2013

Method of increasing immunological effect

Inventors: John W. Hadden (Cold Spring Harbor, NY); Theresa L. Whiteside-Nimick (Pittsburgh, PA); James E. Egan (Stony Brook, NY); Kathy L. Signorelli-Petrat (Springfield, VA); Harvey Brandwein (East Hills, NY)
Assignee: IRX Therapeutics, Inc.
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Quick Facts
Patent No.
US 8,591,956
App. No.
13/205,229
Granted
Nov 26, 2013
Kind
B2
Abstract

A method of increasing immunological effect in a patient by administering an effective amount of a primary cell derived biologic to the patient, inducing immune production, blocking immune destruction, and increasing immunological effect in the patient. Methods of treating an immune target, treating a tumor, immune prophylaxis, and preventing tumor escape.

Claims (5)

1. In a method of cytoprotective cancer therapy, the improvement comprising ex-vivo pre-incubation of T cells from a patient with an effective amount of a primary cell derived biologic, prior to administering said T cells to the patient.

2. The method of claim 1 wherein the primary cell derived biologic comprises interleukin 1beta (IL-1beta), interleukin 2(IL-2), interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor alpha (TNF-alpha), and interferon-gamma (IFN-gamma).

3. The method of claim 1 , wherein the T cells are primary blood-derived T cells from the patient.

4. The method of claim 3 , wherein the T cells comprise CD4 positive T cells.

5. The method of claim 3 , wherein the T cells comprise CD8 positive T cells.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 25, 2019
From: IRX THERAPEUTICS, INC.
To: BROOKLYN IMMUNOTHERAPEUTICS LLC
Reel/Frame 048424/0096 →
RELEASE OF SECURITY INTEREST Recorded Dec 13, 2013
From: KOHN & ASSOCIATES PLLC; KOHN, KENNETH I.
To: UNIVERSITY OF SOUTH FLORIDA; IRX THERAPEUTICS, INC.
Reel/Frame 031782/0396 →
LIEN Recorded Aug 19, 2013
From: UNIVERSITY OF SOUTH FLORIDA; IRX THERAPEUTICS, INC.
To: KOHN & ASSOCIATES PLLC
Reel/Frame 031035/0212 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 11, 2013
From: HADDEN, JOHN W.; WHITESIDE, THERESA L.; CZYSTOWSKA, MARGARATA; EGAN, JAMES E.; SIGNORELLI, KATHY L.; BRANDWEIN, HARVEY
To: IRX THERAPEUTICS, INC.
Reel/Frame 030194/0671 →
Continuity (4)
Division 12323595 · Nov 26, 2008
Provisional Application 60990759 · Nov 28, 2007
Provisional Application 61056925 · May 29, 2008
Related Publication 20120141512A1 · Jun 7, 2012