IP Library › Granted Patent US 8,592,584
Granted Patent B2
US 8,592,584 · App. 13/087,595 · Granted Nov 26, 2013

Compositions and methods including cell death inducers and procaspase activation

Inventors: Paul J. Hergenrother (Champaign, IL); Karson S. Putt (Champaign, IL); Quinn P. Peterson (Savoy, IL); Valerie Fako (Naperville, IL)
Assignee: The Board of Trustees of the of The University of Illinois
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Quick Facts
Patent No.
US 8,592,584
App. No.
13/087,595
Granted
Nov 26, 2013
Kind
B2
Abstract

Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.

Claims (2)

1. A composition comprising a compound of formula:

and a pharmaceutically acceptable carrier.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 26, 2011
From: HERGENROTHER, PAUL J.; PUTT, KARSON S.; PETERSON, QUINN P.; FAKO, VALERIE
To: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Reel/Frame 026344/0122 →
Continuity (6)
Continuation 12597287
Continuation In Part 11420425 · May 25, 2006
Provisional Application 60914592 · Apr 27, 2007
Provisional Application 60684807 · May 26, 2005
Provisional Application 60743878 · Mar 28, 2006
Related Publication 20110257398A1 · Oct 20, 2011