IP Library › Granted Patent US 8,598,323
Granted Patent B2
US 8,598,323 · App. 13/378,229 · Granted Dec 3, 2013

Galectin-immunoglobulin chimeric molecules

Inventors: Charles J. Dimitroff (Hanover, MA); Filiberto Cedeno Laurent (Jamaica Plain, MA); Steven R. Barthel (Allston, MA)
Assignee: The Brigham and Women's Hospital, Inc.
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Quick Facts
Patent No.
US 8,598,323
App. No.
13/378,229
Granted
Dec 3, 2013
Kind
B2
Abstract

Described are Galectin-1/Ig fusion constructs and methods of use thereof, e.g., in diagnostic and biomedical assays, and as therapeutic agents for the treatment of conditions associated with immune dysfunction, e.g., autoimmune diseases, and cancers.

Claims (5)

1. An isolated Galectin-1-Ig (Gal-Ig) fusion construct, comprising: a first portion comprising a mouse Galectin-1 polypeptide comprising SEQ ID NO:2, and a second portion comprising an Fc fragment of a human IgG1 immunoglobulin linked in frame with the first portion, optionally with a linker sequence between the first and second portions.

2. The isolated fusion construct of claim 1 , wherein the mouse Galectin-1 binds to glycoconjugates bearing N-acetyllactosamine (LacNAc) Type 1 (Galβ1,3GlcNAc) or Type 2 (Galβ1-4GlcNAc) disaccharides.

3. The isolated fusion construct of claim 1 , wherein the human IgG1 Fc fragment comprises SEQ ID NO: 4.

4. A pharmaceutical composition comprising the Gal-Ig fusion construct of claim 1 , and a physiologically acceptable carrier.

5. The isolated fusion construct of claim 1 , comprising SEQ ID NO:17.

Assignments (2)
CONFIRMATORY LICENSE Recorded Sep 21, 2015
From: BRIGHAM AND WOMEN'S HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 036644/0300 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 10, 2012
From: DIMITROFF, CHARLES J.; LAURENT, FILIBERTO CEDENO; BARTHEL, STEVEN R.
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 028186/0859 →
Continuity (2)
Provisional Application 61219531 · Jun 23, 2009
Related Publication 20120171205A1 · Jul 5, 2012