System and method for exploiting atrial electrocardiac parameters in assessing left atrial pressure using an implantable medical device
Techniques are provided for assessing left atrial pressure (LAP) based on atrial electrocardiac signal parameters, particularly intra-atrial conduction delay (IACD) and P-wave duration. In one example, a pacemaker or other implantable device senses an intracardiac electrogram (IEGM) or a subcutaneous electrocardiogram (ECG), from which IACD and P-wave duration are derived. The device tracks changes, if any, in the parameters. A significant increase in either IACD or P-wave duration is associated with an increase in LAP. In some examples, conversion factors are calibrated for use with a particular patient to relate IACD and/or P-wave duration values to LAP values to provide an estimate of actual LAP. The conversion factors are pre-calibrated using LAP measurements obtained using a wedge pressure sensor. In other examples, IACD and P-wave duration are instead used to confirm the detection of an elevation in LAP initially made using impedance signals. Other confirmation parameters are described as well.
1. A method for use with an implantable medical device for implant within a patient, the method comprising:
sensing electrocardiac signals within the patient;
detecting atrial parameters within the electrocardiac signals that are affected by left atrial pressure (LAP);
detecting changes in LAP within the patient based on the atrial parameters;
detecting physiological signals representative of left ventricular (LV) overload within the patient; and
wherein the detection of changes in LAP is confirmed based on the detected LV overload.
2. The method of claim 1 wherein detecting atrial parameters affected by LAP includes detecting one or more of: an intra-atrial conduction delay (IACD) and an atrial depolarization event (P-wave) duration.
3. The method of claim 2 wherein detecting changes in LAP within the patient based on the atrial parameters includes associating an increase in IACD with an increase in LAP.
4. The method of claim 2 wherein detecting changes in LAP within the patient based on the atrial parameters includes associating an increase in P-wave duration with an increase in LAP.
5. The method of claim 2 further including calibrating changes in one or both of IACD and P-wave duration to changes in LAP.
6. The method of claim 2 further including:
detecting impedance (Z) signals within the patient;
estimating left atrial pressure (LAP) based on impedance (zLAP); and
detecting changes in LAP within the patient based on zLAP.
7. The method of claim 6 further including using the atrial parameters to confirm a detection of changes in LAP initially made based on zLAP.
8. A method for use with an implantable medical device for implant within a patient, the method comprising:
sensing electrocardiac signals within the patient;
detecting atrial parameters within the electrocardiac signals that are affected by left atrial pressure (LAP);
detecting changes in LAP within the patient based on the atrial parameters;
detecting changes in one or more of heart contractility, systolic time intervals and stroke volumes; and
confirming the detection of changes in LAP based on one or more of heart contractility, systolic time intervals and stroke volumes.
9. A method for use with an implantable medical device for implant within a patient, the method comprising:
sensing electrocardiac signals within the patient;
detecting atrial parameters within the electrocardiac signals that are affected by left atrial pressure (LAP);
detecting changes in LAP within the patient based on the atrial parameters;
detecting ventricular depolarization events (R-waves) within the electrocardiac signals;
detecting impedance (Z);
detecting a time rate of change in impedance (dZ/dt);
measuring an interval between the R-wave and a minimum value of dZ/dt; and
confirming the detection of changes in LAP based on changes in the interval.
10. The method of claim 9 wherein impedance is detected between a supraventricular (SVC) coil and a device housing electrode.
11. A method for use with an implantable medical device for implant within a patient, the method comprising:
sensing electrocardiac signals within the patient;
detecting atrial parameters within the electrocardiac signals that are affected by left atrial pressure (LAP);
detecting changes in LAP within the patient based on the atrial parameters;
detecting ventricular depolarization events (R-waves) within the electrocardiac signals;
detecting changes in R-wave duration; and
confirming the detection of changes in LAP based on changes in R-wave duration.