IP Library › Granted Patent US 8,603,539
Granted Patent B2
US 8,603,539 · App. 13/274,650 · Granted Dec 10, 2013

Compositions for drug delivery

Inventors: Arutla Srinivas (Hyderabad, IN); Harshal P. Bhagwatwar (Hyderabad, IN); Vakati Venkat Arvind (Hyderabad, IN); Saravana Perumal (Hyderabad, IN); Vemula Sathya Narayana (Hyderabad, IN); Mandavalli Srirama Sarveswara Rao (Hyderabad, IN); Venkateswarlu Vobalaboina (Hyderabad, IN); Nookaraju Venkata Sreedharala (Hyderabad, IN)
Assignees: Dr. Reddy's Laboratories Limited; Dr. Reddy's Laboratories, Inc.
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Quick Facts
Patent No.
US 8,603,539
App. No.
13/274,650
Granted
Dec 10, 2013
Kind
B2
Abstract

Substantially non-porous polymeric microparticles comprising a hydrophobic polymer and a plasticizer, and containing therein a bioactive or bioinactive agent.

Claims (15)

1. A composition for topical application, comprising:

substantially non-porous polymeric microparticles, prepared by (i) providing a solution comprising a hydrophobic polymer, a plasticizer, and an active agents; (ii) adding the solution to a hydrophilic liquid to form substantially non-porous polymeric microparticles containing surface pores, internal pores, or both, but having substantially no internal porosity connecting with the surface; and

a fluid vehicle comprising water, a viscosity enhancer, and a surfactant.

2. The composition of claim 1 , wherein microparticles have a surface area ranging from about 0.01 to about 500 m 2 /g.

3. The composition of claim 1 , wherein microparticles have a total pore volume from about 0.00001 cm 3 /g to about 0.1 cm 3 /g.

4. The composition of claim 1 , wherein a hydrophobic polymer comprises a cellulose derivative.

5. The composition of claim 1 , wherein a plasticizer comprises an organic ester, an oil, a glyceride, or a mixture of two or more thereof.

6. The composition of claim 1 , wherein a plasticizer comprises an organic ester.

7. The composition of claim 1 , wherein a hydrophobic polymer comprises ethyl cellulose.

8. The composition of claim 1 , wherein a hydrophilic liquid comprises water.

9. The composition of claim 1 , wherein an active agent comprises a drug substance.

10. The composition of claim 1 , wherein an active agent comprises tretinoin.

11. The composition of claim 1 , wherein an active agent comprises tazarotene.

12. The composition of claim 1 , wherein a plasticizer is water-insoluble.

13. The composition of claim 1 , wherein a solution comprises an organic solvent.

Continuity (3)
Continuation 11916685
Provisional Application 60688087 · Jun 7, 2005
Related Publication 20120041029A1 · Feb 16, 2012