SMAC mimetic
A SMAC mimetic and pharmaceutical compositions thereof and methods of use.
1. A method of treating cancer in a mammal in need thereof that comprises internally administering to the animal an effective amount of Compound 15 of the following formula:
where R5 is —CH 2 CH 3 .
2. The method of claim 1 wherein the cancer is a cancer selected from the group consisting of: sarcomas, bladder cancer, ovarian cancer, breast cancer, brain cancer, pancreatic cancer, colon cancer, blood cancer, skin cancer, lung cancer, and bone cancer.
3. The method of claim 1 wherein the cancer is selected from colorectal cancer, renal carinoma, ovarian carcinoma, pancreatic carcinoma, prostate carcinoma, breast carcinoma, melanoma, gliobastoma, acute myeloid leukemia, small cell lung cell carcinoma, non-small cell lung carcinoma, rhabdomyosarcoma, and basal cell carcinoma.
4. A method for inducing apoptosis in a cancer cell comprising contacting the cell with Compound 15 of the following formula:
where R5 is —CH 2 CH 3 or a pharmaceutically acceptable salt thereof.
5. The method of claim 1 that comprises administering Compound 15 in combination with a second cancer therapy selected from radiation, chemotherapy, immunotherapy, photodynamic therapy, and combinations thereof.
6. The method of claim 2 that comprises administering Compound 15 in combination with a second cancer therapy selected from radiation, chemotherapy, immunotherapy, photodynamic therapy, and combinations thereof.
7. The method of claim 3 that comprises administering Compound 15 in combination with a second cancer therapy selected from radiation, chemotherapy, immunotherapy, photodynamic therapy, and combinations thereof.
8. The method of claim 4 that comprises administering Compound 15 in combination with a second cancer therapy selected from radiation, chemotherapy, immunotherapy, photodynamic therapy, and combinations thereof.