Stabilized, antimicrobially effective composition with a content of bispyridinium alkane
An aqueous-based composition which includes a) at least one bispyridinium alkane (for example octenidine) and b) at least one stabilizer selected from antioxidants, complexing agents, reducing agents, UV filters and photoprotective agents, in particular α-tocopherol, and BHT. The composition can also include c) one or more auxiliaries selected from, for example, nonionic surfactants, ethers, solvents and polymers, in particular fatty alcohol alkoxylates and alkoxylated fatty acid monoglycerides. The presence of the stabilizer reduces or prevents the appearance of decomposition products of bispyridinium alkanes and, in the case of the presence of auxiliaries, of decomposition products of the auxiliaries, such as ethers and peroxides.
1. An aqueous-based composition comprising
a) 0.01% to 20% by weight of octenidine dihydrochloride,
b) 0.0001% to 2.0% by weight of α-tocopherol,
c) 0.01% to 20% by weight of macrogol lauryl ether 20-23
d) at least 50% by weight of water.
2. The composition according to claim 1 , wherein the amount of component b) is 0.001 to 1% by weight.
3. The composition according to claim 1 , further comprising at least one additive selected from the group consisting of:
fruit acid and/or salt thereof,
aroma and/or sweetener, and
acid, base and/or buffer.
4. A mouthwash solution comprising the composition of claim 1 .
5. A method controlling MRSA and/or E. faecalis in a subject, comprising administering to a subject in need thereof, a mouthwash solution or an oral antiseptic comprising an effective amount of the composition of claim 1 .
6. A method for reducing or preventing the formation of degradation products of octenidine dihydrochloride in an aqueous-based composition comprising:
0.0001% to 2.0% by weight of α-tocopherol to an aqueous-based composition comprising
(i) octenidine dihydrochloride, and
(ii) macrogol lauryl ether 20-23
to obtain an aqueous-based composition according to claim 1 .