IP Library › Granted Patent US 8,609,854
Granted Patent B2
US 8,609,854 · App. 13/497,835 · Granted Dec 17, 2013

Process for the preparation of sorafenib tosylate

Inventors: Jagdev Singh Jaryal (Kangra, IN); Swargam Sathyanarayana (Karim Nagar, IN); Rajesh Kumar Thaper (Jammu, IN); Mohan Prasad (Gurgaon, IN)
Assignee: Ranbaxy Laboratories Limited
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Quick Facts
Patent No.
US 8,609,854
App. No.
13/497,835
Granted
Dec 17, 2013
Kind
B2
Abstract

The present invention provides a process for the preparation of sorafenib tosylate, comprising contacting sorafenib free base with p-toluenesulphonic acid in water.

Claims (9)

1. A process for the preparation of crystalline sorafenib tosylate of Formula I

by reacting sorafenib free base with p-toluenesulphonic acid in water, without using any other solvent.

2. The process according to claim 1 , wherein sorafenib free base obtained as a solution directly from a reaction in which the sorafenib free base is formed, is used as such without isolation.

3. The process according to claim 1 , wherein the sorafenib free base is contacted with 1 mole equivalent of p-toluenesulphonic acid.

4. The process according to claim 1 , wherein the sorafenib free base is contacted with 1.5 mole equivalents of p-toluenesulphonic acid.

5. The process according to claim 1 , wherein the sorafenib free base is contacted with more than 1 mole equivalent of p-toluenesulphonic acid.

6. The process according to claim 1 , wherein the sorafenib free base is contacted with p-toluenesulphonic acid at a temperature of 25° C. to 100° C.

7. The process according to claim 1 , wherein the sorafenib free base is contacted with p-toluenesulphonic acid for a period of 2 hours to 20 hours.

8. The process according to claim 1 , wherein a saturated solution of p-toluenesulphonic acid in water is used.

Assignments (2)
MERGER Recorded Jan 13, 2016
From: RANBAXY LABORATORIES LIMTED
To: SUN PHARMACEUTICAL INDUSTRIES LIMITED
Reel/Frame 037513/0475 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2012
From: JARYAL, JAGDEV SINGH; SATHYANARAYANA, SWARGAM; THAPER, RAJESH KUMAR; PRASAD, MOHAN
To: RANBAXY LABORATORIES LIMITED
Reel/Frame 027915/0322 →
Priority Claims (1)
IN 2007/DEL/2009 · Sep 24, 2009 · national
Continuity (1)
Related Publication 20130005980A1 · Jan 3, 2013