Methods and compositions for treating distress dysfunction and enhancing safety and efficacy of specific medications
The present invention relates to methods and compositions for reducing distress dysfunction, including emotional and physical distress. The invention entails co-administration of at least one Receptor Switcher and at least one Endorphin Enhancer. Additionally, at least one Synergistic Enhance and/or at least one Exogenous Opioid are also administered to enhance or prolong the therapeutic effects.
1. A method to safely and effectively treat asthma or chronic obstructive pulmonary disease in a subject in need comprising:
(a) administering a Receptor Switcher to the subject, wherein the Receptor Switcher is naltrexone in an amount of about 1 microgram to about 500 micrograms; and
(b) administering an Endorphin Enhancer, wherein the Endorphin Enhancer is selected from the group consisting of theophylline, roflumilast, ibudilast, cilomilast, zaprinast, rolipram, methylxanthine.
2. The method of claim 1 , wherein the method results in improving respiration.
3. The method of claim 1 , wherein the combination of the Receptor Switcher with the Endorphin Enhancer results in a decrease in side effects associated with administration of the compounds alone.
4. The method of claim 1 , wherein the Receptor Switcher, when co-administered with the Endorphin Enhancer, reduces and/or resolves one or more symptoms of asthma or chronic obstructive pulmonary disease.
5. The method of claim 1 , wherein the subject has previously taken an Endorphin Enhancer, an Exogenous Opioid, a Synergistic Enhancer, or any combination thereof.
6. The method of claim 1 , wherein:
(a) the mode of administration is oral;
(b) the pharmaceutical formulation is delivered in a pharmaceutically-acceptable carrier that is rapid release, immediate-release, slow-release, delayed-released, controlled release, a combination of immediate release and controlled release, a nano-encapsulation formulations, and an abuse and/or tamper-resistant delivery system;
or (c) any combination thereof.