Granted Patent
B2
US 8,624,032 · App. 13/673,719 · Granted Jan 7, 2014
Compound libraries made through phosphine-catalyzed annulation/Tebbe/Diels-Alder reactions
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Abstract
A method for producing libraries of structurally and stereochemically diverse molecules that can be screened for biological or chemical activity. A library of 91 heterocyclic compounds composed of 16 distinct scaffolds was synthesized through a sequence of phosphine-catalyzed ring-forming reactions, Tebbe reactions, Diels-Alder reactions, and, in some cases, hydrolysis to illustrate the methods. Three compounds inhibiting migration of human breast cancer cells are identified from the library.
Claims (1)
1. An antimigratory compound having the formula comprising:
Assignments (4)
CONFIRMATORY LICENSE
Recorded Apr 10, 2014
From: CALIFORNIA, UNIVERSITY OF
To: NAVY, SECRETARY OF THE UNITED STATES OF AMERICA
Reel/Frame 032681/0634 →
CONFIRMATORY LICENSE
Recorded Jul 8, 2013
From: UNIVERSITY OF CALIFORNIA LOS ANGELES
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 030756/0292 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 24, 2013
From: KWON, OHYUN
To: THE REGENTS OF THE UNIVERSTIY OF CALIFORNIA
Reel/Frame 029686/0477 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 22, 2013
From: FENTEANY, GABRIEL
To: CONNECTICUT, UNIVERSITY OF
Reel/Frame 029674/0507 →
Continuity (2)
Provisional Application
61557850
· Nov 9, 2011