Human binding molecules against
Described are human binding molecules specifically binding to enterococci and having killing activity against enterococci , nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The molecules can be used in the diagnosis, prophylaxis, and/or treatment of a condition resulting from Enterococcus.
1. A human monoclonal antibody against Enterococcus species and against at least one strain of Staphylococcus aureus , wherein the antibody comprises:
a heavy chain CDR1 region comprising SEQ ID NO: 55;
a heavy chain CDR2 region comprising SEQ ID NO: 56;
a heavy chain CDR3 region comprising SEQ ID NO: 57;
a light chain CDR1 region comprising SEQ ID NO: 58;
a light chain CDR2 region comprising SEQ ID NO: 59; and
a light chain CDR3 region comprising SEQ ID NO: 60.
2. The human monoclonal antibody of claim 1 , comprising:
a heavy chain comprising a variable heavy chain of SEQ ID NO: 100, and
a light chain comprising a variable light chain of SEQ ID NO: 120.
3. The human monoclonal antibody of claim 1 , wherein the Enterococcus species comprise E. faecalis and E. faecium.
4. The human monoclonal antibody of claim 2 , wherein the Enterococcus species comprise E. faecalis and E. faecium.
5. A pharmaceutical composition comprising:
the human monoclonal antibody of claim 1 , wherein the human monoclonal antibody has opsonic phagocytic killing activity against Enterococcus species and against at least one strain of S. aureus , and
at least one phamiaceutically acceptable excipient.
6. The phaimaceutical composition of claim 5 , further comprising:
at least one other therapeutic agent.
7. An immunoconjugate comprising:
the human monoclonal antibody of claim 1 , and at least one tag.
8. An immunoconjugate comprising:
the human monoclonal antibody of claim 2 , and at least one tag.
9. An immunoconjugate comprising:
the human monoclonal antibody of claim 3 , and at least one tag.
10. An immunoconjugate comprising:
the human monoclonal antibody of claim 4 , and at least one tag.