Adjuvant systems and vaccines
An adjuvant composition comprising monophosphoryl lipid A or a derivative of monophposphoryl lipid A adsorbed onto an aluminium salt particle.
1. A process for manufacturing an immunogenic composition comprising the steps of
(a) providing an adjuvant composition comprising 3-de-O-acylated monophosphoryl lipid A adsorbed onto an aluminum salt particle free of any antigen,
(b) providing a human papilloma virus L1 particle or capsomer adsorbed onto an aluminum salt particle free of any immunostimulant and
(c) mixing the adjuvant composition of step (a) and the human papilloma virus L1 particles or capsomers adsorbed onto the aluminum salt particle of step (b), wherein the aluminum salt particles of step (a) and step (b) are same aluminum salt.
2. The process of claim 1 wherein the aluminum salt is a phosphate or hydroxide.
3. The process of claim 2 wherein the aluminum salt is aluminum hydroxide.